More common side effects
The more common side effects that can occur with Xedenol gel include:
- itching or rash at application site
- stomach pain
Mechanism of Injury
The mechanism of Xedenol induced liver injury appears to be multifactorial, and the cause of mild serum aminotransferase elevations may be different from the cause of serious liver injury. An immuno-allergic component is suggested by the rapid and acute recurrence of injury, even many years after initial exposure and injury. Genetic studies have suggested a linkage with allelic varriants of UGT 2B7, CYP 2C8 and ABC C2, which are genes involved the metabolism, conjugation and excretion of Xedenol.
Xedenol and Grapefruit Juice
Whether grapefruit interacts with Xedenol remains uncertain. Therefore, your best bet is to avoid all grapefruit products while taking Xedenol.
What brand names are available for Xedenol?
Voltaren, Cataflam, Voltaren-XR, Cambia, Zipsor, Zorvolex
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction to Xedenol.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xedenol only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Long-term carcinogenicity studies in rats given Xedenol sodium up to 2 mg/kg/day (approximately 0.1 times maximum recommended human dose (MRHD) of VOLTAREN, 200 mg/day, based on body surface area (BSA) comparison ) have revealed no significant increases in tumor incidence. A 2-year carcinogenicity study conducted in mice employing Xedenol sodium at doses up to 0.3 mg/kg/day (approximately 0.007 times the MRHD based on BSA comparison) in males and 1 mg/kg/day (approximately 0.02 times the MRHD based on BSA comparison) in females did not reveal any oncogenic potential.
Primary dysmenorrhea (painful menstrual period)
The immediate release forms of Xedenol are usually dosed 3 to 4 times a day and start at a dose of 25 mg.
The extended-release form is usually dosed once a day. The dose often starts at 75 mg per day.
Dosage for people younger than 18 years has not been established.
Seniors: If you are aged 65 years and older, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug does not build up in your body. Too much of the drug in your body can be toxic.
On this page
- About Xedenol
- Key facts
- Who can take and can't take Xedenol
- How and when to use them
- Taking Xedenol with other painkillers
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions