Vagi-Metro tablets

Vagi-Metro

  • Active Ingredient: Metronidazole
  • 500 mg, 400 mg, 250 mg, 200 mg
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What is Vagi-Metro?

The active ingredient of Vagi-Metro brand is metronidazole. Metronidazole is an antibiotic that fights bacteria.

Used for

Vagi-Metro is used to treat diseases such as: Amebiasis, Aspiration Pneumonia, Bacteremia, Bacterial Infection, Bacterial Vaginitis, Balantidium coli, Bone infection, Clostridial Infection, Crohn's Disease, Acute, Crohn's Disease, Maintenance, Deep Neck Infection, Dental Abscess, Dientamoeba fragilis, Diverticulitis, Dracunculiasis, Endocarditis, Giardiasis, Helicobacter Pylori Infection, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Meningitis, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Pouchitis, Pseudomembranous Colitis, Skin or Soft Tissue Infection, STD Prophylaxis, Surgical Prophylaxis, Trichomoniasis.

Side Effect

Possible side effects of Vagi-Metro include: loss of voice; voice changes; trouble speaking; redness of the skin; weakness in the arms, hands, legs, or feet.

How to Buy Vagi-Metro tablets online?

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Michael Stewart, Reviewed by Dr Hannah Gronow | Last edited 21 Mar 2017 | Certified by The Information Standard

Swallow Vagi-Metro tablets with plenty of water. Take them with a meal or a snack.

Do not drink alcohol while you are taking Vagi-Metro, and for 48 hours after finishing your course of treatment.

Space your doses evenly throughout the day, and keep taking the medicine until the course is finished.

Carcinogenesis, Mutagenesis, Impairment Of Fertility

Tumors affecting the liver, lungs, mammary, and lymphatic tissues have been detected in several studies of Vagi-Metro in rats and mice, but not hamsters.

Pulmonary tumors have been observed in all six reported studies in the mouse, including one study in which the animals were dosed on an intermittent schedule (administration during every fourth week only). Malignant liver tumors were increased in male mice treated at approximately 1500 mg/m² (similar to the maximum recommended daily dose, based on body surface area comparisons). Malignant lymphomas and pulmonary neoplasms were also increased with lifetime feeding of the drug to mice. Mammary and hepatic tumors were increased among female rats administered oral Vagi-Metro compared to concurrent controls. Two lifetime tumorigenicity studies in hamsters have been performed and reported to be negative.

Vagi-Metro has shown mutagenic activity in in vitro assay systems including the Ames test. Studies in mammals in vivo have failed to demonstrate a potential for genetic damage.

Vagi-Metro failed to produce any adverse effects on fertility or testicular function in male rats at doses up at 400 mg/kg/day (similar to the maximum recommended clinical dose, based on body surface area comparisons) for 28 days. However, rats treated at the same dose for 6 weeks or longer were infertile and showed severe degeneration of the seminiferous epithelium in the testes as well as marked decreases in testicular spermatid counts and epididymal sperm counts. Fertility was restored in most rats after an eight week, drug-free recovery period.

Drug/Laboratory Test Interactions

Vagi-Metro may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and glucose hexokinase. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD+ NADH). Interference is due to the similarity in absorbance peaks of NADH (340 nm) and Vagi-Metro (322 nm) at pH 7.

Getting the most from your treatment

  • Important: do not drink alcohol while you are on Vagi-Metro and for 48 hours after finishing your course of treatment. This is because drinking alcohol with Vagi-Metro is likely to make you feel very sick and cause other unpleasant effects, such as the sensation of having a 'thumping heart' (palpitations), hot flushes and headache.
  • While you are taking Vagi-Metro your urine may look a darker colour than normal. On its own this is nothing to worry about. However, if you also experience tummy (abdominal) pain, or if you feel sick (nausea) or feel generally unwell, you should let your doctor know.
  • If you buy any medicines, check with a pharmacist that they are safe to take with Vagi-Metro. Some cough and cold preparations contain alcohol and should not be taken with Vagi-Metro.
  • If you need to take Vagi-Metro for longer than ten days, your doctor may want you to have some tests. Make sure you keep any appointments that your doctor gives to you.

Study Data

There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used Vagi-Metro systemically during pregnancy

Many studies included first trimester exposures

One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to Vagi-Metro in utero; however, these findings were not confirmed

In addition, more than 10 randomized, placebo-controlled clinical trials that together enrolled over 5000 pregnant women assessed the possible effect of systemic antibiotic treatment (including with Vagi-Metro) for bacterial vaginosis on the incidence of preterm delivery; most studies did not show an increased risk of congenital anomalies or other adverse fetal outcomes following Vagi-Metro exposure during pregnancy

Three studies conducted to assess the risk of infant cancer following systemic Vagi-Metro exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited

Metron >About Vagi-Metro
  • Before taking Vagi-Metro
  • How to take Vagi-Metro
  • Getting the most from your treatment
  • Can Vagi-Metro cause problems?
  • How to store Vagi-Metro
  • Important information about all medicines
  • Serious side effects

    Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects can include:

    • Nervous system effects, including seizures and encephalopathy (abnormal brain function). Symptoms can include:
      • convulsions (sudden movements caused by tightening of your muscles)
      • dizziness
      • headache
      • confusion
      • ataxia (loss of control of body movements)

    Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Side effects for men vs. womenFor the most part, the side effects of Vagi-Metro for men and women are the same. The only real differences in side effects affect women. For instance, Vagi-Metro increases the risk of yeast infections, which occur much more often in women. Also, Vagi-Metro can cause vaginal irritation and discharge.

    Vagi-Metro oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Vagi-Metro are listed below.

    Common Side Effects of Vagi-Metro

    Tell your doctor if any of the following side effects become severe or don't go away:

    • Vomiting
    • Mild diarrhea
    • Upset stomach
    • Loss of appetite
    • Dizziness
    • Cough, sneezing, or runny nose
    • Dry mouth or metallic taste
    • Dark or reddish-brown urine
    • Mouth or tongue irritation
    • Vaginal itching or discharge

    Lactation

    Vagi-Metro is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels

    Because of potential for tumorigenicity shown for Vagi-Metro in mouse and rat studies, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother; alternatively, a nursing mother may choose to pump and discard human milk for duration of Vagi-Metro therapy, and for 24 hours after therapy ends and feed her infant stored human milk or formula

    Introduction

    Vagi-Metro is a nitroimidazole derivative bactericidal agent widely used in the treatment of many anaerobic and certain protozoan and parasitic infections. Vagi-Metro has been linked to rare instances of acute, clinically apparent liver injury.


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