Urigon gel

Urigon

  • Active Ingredient: Diclofenac
  • 100 mg
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What is Urigon?

The active ingredient of Urigon brand is diclofenac. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. The inactive ingredients in Diclofenac sodium delayed-release tablets include: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium starch glycolate, talc, titanium dioxide, triethyl citrate.

Used for

Urigon is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Frozen Shoulder, Migraine, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica, Spondyloarthritis.

Side Effect

Possible side effects of Urigon include: feeling of indigestion; weight loss; pale skin; stupor; hives.

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Warnings for people with certain health conditions

For people with high blood pressure or water retention: Tell your doctor before using Urigon. Your heart may already be working hard, and adding an NSAID can increase this workload.

For people with ulcer or digestive bleeding: If you’ve had an ulcer or bleeding from your digestive system, ask your doctor before using Urigon. You’re at increased risk for another bleed.

For people with kidney disease or taking diuretics: If you have kidney disease or take diuretics (water pills), there’s a risk this drug can affect your kidneys’ ability to remove excess water from your body. Ask your doctor if Urigon is the right drug for you.

For people with asthma and aspirin reactions: If you have asthma and you react to aspirin, you could have a bad reaction to Urigon. Talk to your doctor before using the drug.

Tablets and capsules

Swallow the Urigon tablets or capsules with a glass of water or milk. Swallow them whole - do not crush, break or chew them.

Always take your Urigon tablets or capsules after a meal or snack, or with a drink of milk. They'll be less likely to upset or irritate your stomach.

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Urigon. For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect to the UK safety scheme.

CONTRAINDICATIONS

VOLTAREN ® is contraindicated in the following patients:

  • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to Urigon or any components of the drug product (see WARNINGS; Anaphylactic Reactions, Serious Skin Reactions).
  • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients (see WARNINGS; Anaphylactic Reaction, Exacerbation Of Asthma Related To Aspirin Sensitivity).
  • In the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS; Cardiovascular Thrombotic Events).

Q: Could Urigon cause excess bleeding from dental surgery?

A: Urigon (Cataflam, Flector, Voltaren-XR, Zipsor) can affect platelets and may prolong bleeding. As always, consult with your health care provider regarding what medications need to be stopped prior to dental surgery. Jennyfer Marisco, RPh

Digoxin

Taking digoxin with Urigon can lead to increased levels of digoxin in your body and increased side effects. Your doctor may monitor your digoxin levels closely.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

How should this medicine be used?

Urigon comes as a tablet, and liquid-filled capsule, a hard gelatin capsule, an extended-release (long-acting) tablet, a delayed-release (releases medication in the intestine) tablet, and as packets of powder for solution (to be mixed with water) and take by mouth. Urigon liquid-filled capsules are usually taken 4 times a day and Urigon hard gelatin capsules are usually taken three times a day on an empty stomach. Urigon extended-release tablets are usually taken once a day, and in rare cases are taken twice a day, if needed to control pain. Urigon tablets and Urigon delayed-release tablets are usually taken 2, 3, or 4 times a day. Urigon solution is taken without food as a one dose treatment to relieve the pain of migraine headaches. If you were told to take Urigon on a regular basis, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Urigon exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Different Urigon products release the medication differently in your body and cannot be used interchangeably. Only take the Urigon product prescribed by your doctor and do not switch to a different Urigon product unless your doctor says that you should.

Your doctor may adjust the dose of your medication during your treatment depending on your response to the medication. Talk to your doctor about how you are feeling during your treatment with Urigon.

If you are taking the powder for solution, you will need to mix it with water before you take it. To mix the medication, first remove one packet from a row of three attached packets. Place 2 to 4 tablespoons (1 to 2 ounces; 30 to 60 mL) of water in a cup. Add the contents of the packet and mix well. Drink the entire mixture right away. Throw away the empty packet in a trash can that is out of the reach of children and pets.

Mechanism Of Action

Urigon has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Urigon is a potent inhibitor of prostaglandin synthesis in vitro. Urigon concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Urigon is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Rare Side Effects

In severe cases, Urigon may cause a deadly liver condition known as fatal fulminant hepatitis.

Get medical help if you have any yellowing or graying of the skin or eyes, if your lower extremities or abdomen is swelling, if you are extra sleepy, or become confused.

Based on available data, Urigon may be present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for VOLTAREN and any potential adverse effects on the breastfed infant from the VOLTAREN or from the underlying maternal condition.

One woman treated orally with a Urigon salt, 150 mg/day, had a milk Urigon level of 100 mcg/L, equivalent to an infant dose of about 0.03 mg/kg/day. Urigon was not detectable in breast milk in 12 women using Urigon (after either 100 mg/day orally for 7 days or a single 50 mg intramuscular dose administered in the immediate postpartum period).

Immunosuppressant drug

Taking cyclosporine, a drug that weakens your immune system, with Urigon may increase your risk for kidney problems.

Urigon interactions and warnings

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking your Urigon dosage, it is important that your doctor knows:

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
  • If you have a heart condition, or a problem with your blood vessels or circulation.
  • If you are pregnant or breastfeeding.
  • If you have high blood pressure.
  • If you have any blood clotting problems.
  • If you have a connective tissue disorder, such as a condition called systemic lupus erythematosus (SLE).
  • If you have problems with the way your liver works, or problems with the way your k >

Missed Dose of Urigon

If you miss a dose of Urigon, try to take it as soon as you remember, unless it is almost time for the next dose. In that case, skip the missed dose and take your next dose at the regular time.

Do not take two doses of the medication at the same time.

What is Urigon, and how does it work (mechanism of action)?

Urigon belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used for the treatment of mild to moderate pain, fever, and inflammation. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen), naproxen (Aleve) and several others. NSAIDs work by reducing the production of prostaglandins, chemicals that cause pain, fever and inflammation. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower production of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition. The FDA approved Urigon in July 1998.


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