Uniclophen tablets

Uniclophen

  • Active Ingredient: Diclofenac
  • 100 mg
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What is Uniclophen?

The active ingredient of Uniclophen brand is diclofenac. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. The inactive ingredients in Diclofenac sodium delayed-release tablets include: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium starch glycolate, talc, titanium dioxide, triethyl citrate.

Used for

Uniclophen is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Frozen Shoulder, Migraine, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica, Spondyloarthritis.

Side Effect

Possible side effects of Uniclophen include: Continuing ringing or buzzing or other unexplained noise in the ears; seizures; change in consciousness; intravenous solution; itching skin or rash; pale or blue lips, fingernails, or skin; vomiting of blood or material that looks like coffee grounds; loss of consciousness.

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On this page

  1. About Uniclophen
  2. Key facts
  3. Who can take and can't take Uniclophen
  4. How and when to use them
  5. Taking Uniclophen with other painkillers
  6. Side effects
  7. How to cope with side effects
  8. Pregnancy and breastfeeding
  9. Cautions with other medicines
  10. Common questions

Digoxin

Taking digoxin with Uniclophen can lead to increased levels of digoxin in your body and increased side effects. Your doctor may monitor your digoxin levels closely.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Prescribed for Back Pain, Frozen Shoulder, Ankylosing Spondylitis, Aseptic Necrosis, Migraine, Spondyloarthritis, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica.

Uniclophen may also be used for purposes not listed in this medication guide.

Prescribed for Back Pain, Chronic Myofascial Pain, Costochondritis, Aseptic Necrosis, Headache, Muscle Pain, Fever, Patent Ductus Arteriosus, Gout - Acute, Radiculopathy, Polymyalgia Rheumatica, Sciatica, Rheumatoid Arthritis, Spondylolisthesis, Temporomandibular Joint Disorder, Toothache, Plantar Fasciitis, Neck Pain, Period Pain, Pain, Osteoarthritis, Juvenile Rheumatoid Arthritis, Frozen Shoulder, Eustachian Tube Dysfunction, Dysautonomia, Diffuse Idiopathic Skeletal Hyperostosis, Transverse Myelitis.

May also be prescribed off label for Herniated Disk.

Mechanism Of Action

Uniclophen has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Uniclophen is a potent inhibitor of prostaglandin synthesis in vitro. Uniclophen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Uniclophen is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Important information

You should not use Uniclophen if you have a history of allergic reaction to aspirin or NSAIDs (non-steroidal anti-inflammatory drugs).

Uniclophen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Uniclophen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

Special Populations

Pediatric: The pharmacokinetics of VOLTAREN has not been investigated in pediatric patients.

Race: Pharmacokinetic differences due to race have not been identified.

Hepatic Impairment: Hepatic metabolism accounts for almost 100% of VOLTAREN elimination, so patients with hepatic disease may require reduced doses of VOLTAREN compared to patients with normal hepatic function.

Renal Impairment: Uniclophen pharmacokinetics has been investigated in subjects with renal insufficiency. No differences in the pharmacokinetics of Uniclophen have been detected in studies of patients with renal impairment. In patients with renal impairment (inulin clearance 60-90, 30-60, and

Uniclophen suppositories

Suppositories are medicine that you push gently into your back passage (anus).

  • Go to the toilet beforehand if you need to.
  • Wash your hands before and after using the medicine. Also clean around your back passage with mild soap and water, rinse and pat dry.
  • Unwrap the suppository.
  • Gently push the suppository into your back passage (anus) with the pointed end first. It needs to go in about 3 centimetres (1 inch).
  • Sit or lie still for about 15 minutes. The suppository will melt inside your back passage. This is normal.

What are the side effects of Uniclophen?

The most common side effects of Uniclophen involve the gastrointestinal system, such as:

  • ulcerations,
  • abdominal burning,
  • pain,
  • cramping,
  • nausea,
  • gastritis,
  • serious gastrointestinal bleeding, and
  • liver toxicity.

Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness are also seen.

Other important side effects include:

People who are allergic to other NSAIDs should not use Uniclophen. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with already reduced kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously. Individuals with asthma are more likely to experience allergic reactions to Uniclophen and other NSAIDs.

Uniclophen Vs Ibuprofen side effects

The incidence of these side effects will be increrased if ibuprofen and Uniclophen are taken together or overdosed.

Q: How safe is the NSAID Uniclophen? The side effects listed on the medication are heart attacks or stroke.

A: FDA has concluded that all non-steroidal anti-inflammatory drugs (NSAIDs), the class of drugs that includes Uniclophen, carry an increased risk of heart attack and stroke. As a precaution, it is generally recommended to avoid the use of these drugs in patients with known cardiac risk factors. The risk appears to increase with longer use of the drugs. Always discuss your medical history and each of your medications with your health care provider. For more specific information: //www.everydayhealth.com/drugs/Uniclophen

How to use Uniclophen Sodium

Read the Medication Guide provided by your pharmacist before you start using Uniclophen and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with a full glass of water (8 ounces / 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. If you experience stomach upset with this medication, you may take it with food, milk, or an antacid. However, this may slow absorption and delay pain relief, especially if you are not taking this medication on a regular schedule.

Swallow this medication whole. Do not crush, chew, or break the tablets. Doing so can destroy the special coating on the tablet and may increase side effects.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

For certain conditions (such as arthritis), it may take up to 2 weeks of regular use before the full benefits of this drug take effect.

If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition worsens.

Heart Failure And Edema

The Coxib and traditional NSAID Trialists’ Collaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalization for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patients. In a Danish National Registry study of patients with heart failure, NSAID use increased the risk of MI, hospitalization for heart failure, and death.

Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs. Use of Uniclophen may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers ) (see DRUG INTERACTIONS).

Avoid the use of VOLTAREN in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failure. If VOLTAREN is used in patients with severe heart failure, monitor patients for signs of worsening heart failure.

FDA warning: Nonstero >
  • This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Uniclophen is a nonsteroidal anti-inflammatory drug (NSAID). All NSAIDs can increase your risk of heart attack, heart failure, or stroke. This risk can go up the longer you use NSAIDs, and if you use high doses. Your risk may be higher if you have risk factors for heart disease, such as high blood pressure. If you have heart disease, talk to your doctor before using Uniclophen. You shouldn’t use Uniclophen before you have surgery, especially heart bypass surgery. Talk to your doctor if you use Uniclophen and will have surgery soon. NSAIDs such as Uniclophen can increase your risk of serious side effects, including stomach bleeding or ulcers.

What is Uniclophen? What is Uniclophen used for?

Uniclophen is a Generic name for nonsteroidal anti-inflammatory drug (NSAID). This drug works by lowering substances (prostaglandins) in the body that are main cause of pain and inflammation.

Uniclophen is most commonly taken in order to relieve pain, swelling and inflammation that may be caused by injuries and different health conditions such as rheumatoid arthritis, osteoarthritis, painful menstruation periods, migraines, and ankylosing splondylitis. It is available in different dosages and forms on the market.

Most commonly it is used as delayed release tablet in dose of 25 mg and 50 mg and as extended release tablet in doses of 75 mg and 100 mg. It is also available in the form of solution and powder for injection, gel, cream, patch and suppository of 50 mg and 100 mg. FDA approved Uniclophen in 1998.

It is originally manufactured by Novartis. This drug is also available under different brand names, such as Voltaren, Solaraze, Pennsaid, Cataflam, Zipsor and Zorvolex.

Long-term carcinogenicity studies in rats given Uniclophen sodium up to 2 mg/kg/day (approximately 0.1 times maximum recommended human dose (MRHD) of VOLTAREN, 200 mg/day, based on body surface area (BSA) comparison ) have revealed no significant increases in tumor incidence. A 2-year carcinogenicity study conducted in mice employing Uniclophen sodium at doses up to 0.3 mg/kg/day (approximately 0.007 times the MRHD based on BSA comparison) in males and 1 mg/kg/day (approximately 0.02 times the MRHD based on BSA comparison) in females did not reveal any oncogenic potential.


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