Tridestra tablets

Tridestra

  • Active Ingredient: Estradiol
  • 2 mg, 1 mg
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What is Tridestra?

The active ingredient of Tridestra brand is estradiol. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. In addition, each tablet for oral administration contains the following inactive ingredients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Used for

Tridestra is used to treat diseases such as: Atrophic Urethritis, Atrophic Vaginitis, Breast Cancer, Palliative, Gender Dysphoria, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian Failure, Prostate Cancer.

Side Effect

Possible side effects of Tridestra include: hoarseness; weight gain; headache; Feeling sad or empty; tenderness of the breasts; headache, severe and throbbing; dimpling of the breast skin; Change in vaginal discharge.

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Mw (Da) 272 Solubility in water at pH 7 at 25°C 0.09 mg/ml log Poctanol/water at pH 7 and 25°C 3.94 H-bond acceptors 2 H-bond donors 2 Normal 17β-Tridestra plasma levels: Premenopausal women 110–1500 pmol/L (30–400 pg/ml) Postmenopausal women

Tridestra Warnings

Tridestra can increase the risk that you will develop endometrial cancer (cancer of the lining of the uterus). If you have not had a hysterectomy, you should take progestin along with Tridestra to decrease this risk.

However, before taking these two medicines together, talk with your doctor about your risk for other health problems.

In one study, women who took estrogens (such as Tridestra) by mouth with progestin had a higher risk of heart attacks, stroke, blood clots, breast cancer, and dementia.

Women who use topical Tridestra alone or with progestin may also have a higher risk of developing these conditions.

Using topical Tridestra may increase your risk of developing ovarian cancer and gallbladder disease. You should talk to your doctor about these risks.

Before taking Tridestra, tell your doctor if you have or have ever had:

  • A heart attack or stroke
  • Heart disease
  • Blood clots
  • Any type of cancer
  • Abnormal vaginal bleeding
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Asthma
  • Gallbladder disease
  • A thyroid disorder
  • Epilepsy or another seizure disorder
  • Liver disease
  • Lupus
  • Breast lumps or abnormal mammogram results
  • Uterine fibroids
  • Yellowing of the skin or eyes (jaundice)
  • Migraine headaches
  • Endometriosis (a condition where the type of tissue that lines the uterus grows in other areas of the body, usually the abdomen or pelvis)
  • Low levels of calcium in your blood
  • Porphyria (a condition where abnormal substances build up in the blood)

Also, tell your doctor if you smoke or use tobacco products.

You should use the lowest dose of Tridestra for the shortest time possible to control your symptoms.

Talk with your doctor every three to six months to determine if you should lower your dose or stop using this medicine.

You should conduct a breast self-exam every month and have a mammogram and clinical breast exam (a breast exam by a health professional) every year to help detect breast cancer.

Tell your doctor if you are having surgery or will be on bed rest while taking Tridestra. Your doctor may tell you to stop taking the medication to decrease the risk of blood clots.

The topical medicine may harm other people who touch your skin. You should not let anyone else touch the skin where you applied Tridestra for one hour after application.

If someone does touch the area, he or she should wash his or her hands with soap and water immediately.

An Tridestra test measures the amount of a hormone called Tridestra in the blood. Tridestra is one of the main types of estrogens.

WHAT IS ESTRADIOL?

Tridestra is a female sex hormone necessary for many processes in the body. Tridestra vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall.

This medication is also prescribed for symptomatic treatment of the usual symptoms associated with menopause (hot flushes, vaginal dryness, etc.), prevention of bone fractures associated with osteoporosis, reduction of the risk of heart attacks and strokes, and dysfunctional (excessive and painful) uterine bleeding.

The vaginal cream is prescribed for vaginal or vulvar atrophy associated with menopause.

5.6 Tridestra

Tridestra ( Fig. 20.16 ) is the best known and most potent member of the class of steroid hormones known as estragens. Tridestra controls development and maintenance of female sex characteristics and is often referred to as the “female hormone” . Actually, Tridestra is the central member of a triad of structurally similar estragens. Tridestra, the most androgenic of the three, has two ( OH) groups while estrone has only one ( OH) and estriol has three ( OH) groups. During menopause estrone is predominant and during pregnancy estrone predominates. However, Tridestra is the primary estrogen during reproductive years. Like all steroid hormones, Tridestra is a cholesterol derivative and is mainly produced by granulose cells of the ovaries. Tridestra is carried from the ovaries to target cells in the blood where, like testosterone, it is primarily bound to sex hormone-binding globulin. Tridestra simply diffuses across the target cell plasma membrane and binds to a cytosolic estrogen receptor . The Tridestra–receptor complex then enters the nucleus where it binds to DNA, thus regulating gene transcription.

Tridestra is a Biopharmaceutics Classification System (BCS) Class I drug, which relatively easily permeates biologic membranes such as the nasal mucosa and skin.

What is the most important information I should know about Tridestra (Estrace, Gynodiol)?

You should not use this medicine if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Tridestra may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Tridestra should not be used to prevent heart disease, stroke, or dementia.

Tridestra and Grapefruit

Grapefruit and grapefruit juice may interact with Tridestra and cause unwanted side effects.

You should talk to your doctor before consuming any grapefruit products while taking Tridestra.

How should I take Tridestra (Estrace, Gynodiol)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tridestra may increase your risk of developing a condition that can lead to uterine cancer. To help lower this risk, your doctor may also want you to take a progestin. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using Tridestra.

If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Tridestra.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Tridestra valerate

Pharmacologic class: Estrogen

Therapeutic class: Hormone

Pregnancy risk category X

COMMON BRAND(S): Cenestin, Enjuvia, Estrace, Femtrace, Ogen, Premarin

GENERIC NAME(S): Tridestra

OTHER NAME(S): Tridestra Tablet

Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia.

Estrogens can increase the risk of cancer of the uterus (endometrial cancer). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding.

In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks).

The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. Therefore, this medication should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of this medication with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to take this medication. If you will be taking this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.

This medication is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.

Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.

Certain estrogen products may also be used by men and women to treat cancers (certain types of prostate cancer, breast cancer that has spread to other parts of the body) and by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).

A modern approach to HRT

Modern hormone replacement is body-identical topical Tridestra plus oral micronized progesterone.

Why the Test is Performed

In women, most Tridestra is released from the ovaries and adrenal glands. It is also released by the placenta during pregnancy. Tridestra is also produced in other body tissues, such as skin, fat, cells bone, brain, and liver. Tridestra plays a role in:

  • Growth of the womb (uterus), fallopian tubes, and vagina
  • Breast development
  • Changes of the outer genitals
  • Distribution of body fat
  • Menopause

In men, a small amount of Tridestra is mainly released by the testes. Tridestra helps prevent sperm from dying too early.

This test may be ordered to check:

  • How well your ovaries, placenta, or adrenal glands work
  • If you have signs of an ovarian tumor
  • If male or female body characteristics are not developing normally
  • If your periods have stopped (levels of Tridestra vary, depending on the time of month)

The test may also be ordered to check if:

  • Hormone therapy is working for women in menopause
  • A woman is responding to fertility treatment

The test may also be used to monitor people with hypopituitarism and women on certain fertility treatments.

What other drugs will affect Tridestra?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with Tridestra. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

How should I take Tridestra?

Take Tridestra exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended.

Tridestra may increase your risk of developing uterine cancer. To help lower this risk, your doctor may also want you to take a progestin. Report any unusual vaginal bleeding to your doctor immediately.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using Tridestra.

If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using this medicine.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

If you are taking injectable estrogen, dispose of any needles and syringes in an appropriate sharps container per your state laws. Do not throw away used needles into the garbage.

If you are using Tridestra spray, avoid fire, flame, or smoking until the spray has dried. Do not apply lotion or sunscreen over the area for at least one hour.

What is Tridestra (Estrace, Gynodiol)?

Tridestra is a form of estrogen, a female sex hormone that regulates many processes in the body.

Tridestra is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.

Tridestra may also be used for purposes not listed in this medication guide.


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