How it works
Trichostatic belongs to a class of drugs called nitroimidazole antimicrobials. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Antimicrobials are drugs used to treat infections. Nitroimidazole antimicrobials treat infections caused by bacteria and other organisms called protozoa. Trichostatic tablets work by killing the bacteria or other organism that’s causing the infection. This relieves the infection.
Trichostatic oral tablet doesn’t cause drowsiness, but it can cause other side effects.
What are the side effects of Trichostatic?
Flagyl is a useful antibiotic and is generally well tolerated with appropriate use.
The most common and minor side effects include:
Side effects that are uncomfortable, but may become serious include:
- Brain disease
- Mouth sores
- Pain with urination
- Prickling or tingling sensations that may become permanent
- Pelvic pain or pressure
- Decrease of libido
Serious side effects of Flagyl are rare and the drug should be stopped if these symptoms appear:
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
- numbness, pain, burning, or tingling in your hands or feet
- peeling or blistering skin
- stuffy nose, fever, sore throat, or other signs of infection
- joint pain
- difficulty speaking
- problems with coordination
Trichostatic may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Drugs you should not take with Trichostatic
Disulfiram: Do not take disulfiram with Trichostatic. Doing so can cause dangerous effects in your body. Using it with Trichostatic can cause psychotic reactions. Symptoms can include:
- hallucinations (seeing or hearing things that aren’t real)
- delusions (believing things that aren’t real)
Do not take Trichostatic if you’ve taken disulfiram in the last two weeks.
Before taking this medicine
You should not take Trichostatic if you are allergic to it, or if you have taken disulfiram (Antabuse) within the past 2 weeks.
Using Trichostatic during the first trimester of pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.
To make sure Trichostatic is safe for you, tell your doctor if you have ever had:
liver or kidney disease;
nervous system disease;
Cockayne syndrome (a rare genetic disorder);
a stomach or intestinal disease such as Crohn's disease;
a blood cell disorder such as anemia (lack of red blood cells) or low white blood cell (WBC) counts;
a fungal infection anywhere in your body; or
a nerve disorder.
In animal studies, Trichostatic caused certain types of tumors, some of which were cancerous. However, very high doses are used in animal studies. It is not known whether these effects would occur in people using regular doses. Ask your doctor about your risk.
Trichostatic can pass into breast milk. It is not known whether Trichostatic can harm a nursing baby. Let your doctor know if you are breastfeeding prior to taking Trichostatic.
Do not give this medicine to a child without medical advice.
How to use Trichostatic
Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.
For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition lasts or gets worse.
What if I forget to use it?
If you forget to use Trichostatic cream or gel, put it on as soon as you remember, unless it's nearly time for your next dose. Do not use it more than twice a day unless your doctor tells you to. Then continue to use the cream or gel at the usual time.
Metron >About Trichostatic
In patients stabilized on relatively high doses of lithium, short-term Trichostatic therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity. Serum lithium and serum creatinine levels should be obtained several days after beginning Trichostatic to detect any increase that may precede clinical symptoms of lithium intoxication.
4. Tablets, liqu >
Trichostatic tablets, liquid and suppositories are prescribed for a number of infections, including pelvic inflammatory disease. The form your doctor prescribes, the dose and how long you'll need to take the medicine for depends on the type of infection and how serious it is.
Some infections can be treated with a single dose, while others may need a 2 week course. Children's doses are lower and depend on the age or weight of your child. Follow the instructions from your doctor or pharmacist.
Trichostatic tablets should be swallowed whole with a drink of water, after you've eaten some food.
Trichostatic liquid does not need to be taken after food. This medicine comes with a plastic syringe or spoon to help you measure out the right dose. If you don't have one, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not give the right amount.
Your doctor may prescribe Trichostatic suppositories if you have difficulty swallowing medicines. Trichostatic suppositories are usually used 3 times a day. Follow the instructions that come in the packaging with your medicine.
If you need to take several doses of Trichostatic a day, try to space them evenly. For example, if you take your medicine 3 times a day, this could be first thing in the morning, mid-afternoon, and at bedtime.
Which drugs or supplements interact with this medication?
- Alcohol should be avoided because Trichostatic and alcohol together can cause severe nausea, vomiting, cramps, flushing, and headache.
- Trichostatic can increase the blood thinning effects of warfarin (Coumadin, Jantoven) and increase the risk of bleeding probably by reducing the breakdown of warfarin.
- Cimetidine (Tagamet) increases blood levels of Trichostatic while cholestyramine (Questran, Questran Light) reduces blood levels of Trichostatic by reducing its absorption.
- Trichostatic should not be combined with amprenavir (Agenerase) for treating human immunodeficiency disease (infection with HIV) because amprenavir contains propylene glycol.
- Trichostatic blocks the breakdown of propylene glycol in the liver leading to accumulation of propylene glycol in blood. Accumulation of propylene glycol could cause seizures, increased heart rate, and lead to kidney failure.
- Trichostatic increases the blood levels of carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol), lithium (Eskalith, Lithobid) and cyclosporine though unknown mechanisms. Serious reactions may occur if these drugs are taken with Trichostatic.
Getting the most from your treatment
- Important: do not drink alcohol while you are on Trichostatic and for 48 hours after finishing your course of treatment. This is because drinking alcohol with Trichostatic is likely to make you feel very sick and cause other unpleasant effects, such as the sensation of having a 'thumping heart' (palpitations), hot flushes and headache.
- While you are taking Trichostatic your urine may look a darker colour than normal. On its own this is nothing to worry about. However, if you also experience tummy (abdominal) pain, or if you feel sick (nausea) or feel generally unwell, you should let your doctor know.
- If you buy any medicines, check with a pharmacist that they are safe to take with Trichostatic. Some cough and cold preparations contain alcohol and should not be taken with Trichostatic.
- If you need to take Trichostatic for longer than ten days, your doctor may want you to have some tests. Make sure you keep any appointments that your doctor gives to you.
Drug/Laboratory Test Interactions
Trichostatic may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and glucose hexokinase. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD+ NADH). Interference is due to the similarity in absorbance peaks of NADH (340 nm) and Trichostatic (322 nm) at pH 7.
You should not use Trichostatic if you are allergic to it, or if you have taken disulfiram (Antabuse) within the past 2 weeks.
Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking Trichostatic and for at least 1 day after you stop taking it. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.
Seizures and other nervous system abnormalities have been reported in patients treated with Trichostatic. You should stop Trichostatic immediately for any neurological symptoms such as seizures, headaches, visual changes, weakness, numbness, or tingling.
This medicine will not treat a viral infection such as the common cold or flu.
In animal studies (mice and rats), this medicine caused certain types of cancers or tumors. It is not known whether these effects would occur in people using this medicine. Ask your doctor about your risk.
Trichostatic is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels
Because of potential for tumorigenicity shown for Trichostatic in mouse and rat studies, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother; alternatively, a nursing mother may choose to pump and discard human milk for duration of Trichostatic therapy, and for 24 hours after therapy ends and feed her infant stored human milk or formula
There are no adequate and well-controlled studies of in pregnant women; there are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than 5000 pregnant women who used Trichostatic during pregnancy; many studies included first trimester exposures; one study showed increased risk of cleft lip, with or without cleft palate, in infants exposed to Trichostatic in utero; however, these findings were not confirmed
Trichostatic crosses placental barrier and its effects on human fetal organogenesis are not known; reproduction studies have been performed in rats, rabbits and mice at doses similar to maximum recommended daily dose based on body surface area comparisons; there was no evidence of harm to fetus due to Trichostatic; healthcare provider should carefully consider potential risks and benefits for each specific patient before prescribing therapy