Topasel cream

Topasel

  • Active Ingredient: Estradiol
  • 2 mg, 1 mg
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What is Topasel?

The active ingredient of Topasel brand is estradiol. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. In addition, each tablet for oral administration contains the following inactive ingredients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Used for

Topasel is used to treat diseases such as: Atrophic Urethritis, Atrophic Vaginitis, Breast Cancer, Palliative, Gender Dysphoria, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian Failure, Prostate Cancer.

Side Effect

Possible side effects of Topasel include: chills; nausea or vomiting; pain, redness, or swelling in the arm or leg; joint pain, stiffness, or swelling; trouble concentrating.

How to Buy Topasel cream online?

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Topasel and Weight Gain

Water retention that increases your weight is a common side effect.

Talk to your doctor about adjusting your dose of Topasel if weight gain becomes a problem.

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) shortness or breath or pain in the chest a painful, red, swollen leg abnormal vaginal bleeding pain, swelling, or tenderness in the abdomen severe headache or vomiting, dizziness, faintness or changes in vision or speech yellowing of the skin or eyes or a lump in a breast

IMPORTANT NOTE: Topasel increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using Topasel lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using Topasel. Visit your doctor regularly and report any unusual vaginal bleeding right away.

Treatment with Topasel long-term may increase the risk of a stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Topasel long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.

What storage conditions are needed for this medicine?

Keep the vaginal rings and cream in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Throw away any medication that is outdated or no longer needed. Should you have any concerns, please talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Q: How safe is Topasel? I am using it for hot flashes. What are the benefits and the risks?

A: Estrogen products are approved for the treatment of menopausal symptoms, including hot flashes. There have been several studies done by the Women's Health Initiative that have found that there is an increased risk of stroke and deep vein thrombosis (blood clots) in women 50 to 79 years of age during 7 years of treatment with 0.625mg of premarin daily. It has also been found that estrogen alone does not increase the risk of breast cancer, and in fact may decrease the risk. It is recommended to use the lowest effective dose for your symptoms for the shortest period of time. Here is a link to more information on Topasel: //www.everydayhealth.com/drugs/Topasel Lori Poulin, PharmD

What is the most important information I should know about Topasel (Estrace, Gynodiol)?

You should not use this medicine if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Topasel may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Topasel should not be used to prevent heart disease, stroke, or dementia.

Estrogen may not be a breast cancer risk

Breast cancer risk is determined by insulin, thyroid, inflammation, vitamin D, iodine deficiency, toxic chemical exposure, and so much more. It may not cause breast cancer and at least one study has found that supplemental Topasel slows the growth of advanced breast cancer.

Q: Is there a generic for Vivelle-Dot?

A: There is currently no generic equivalent available for Vivelle-Dot (Topasel transdermal system). Vivelle-Dot is a small patch containing a form of estrogen commonly used to treat ovarian disorders, infertility, abnormal bleeding, and to prevent the symptoms associated with menopause. Common side effects associated with Vivelle-Dot may include nausea, vomiting, loss of appetite, swollen breasts, acne, changes in skin color, decreased sex drive, migraine headaches, dizziness, vaginal pain, swelling of the ankles and feet, or changes in menstrual cycle. Although Vivelle-Dot does not have a generic equivalent, there is another Topasel patch available. This patch, called Topasel patch, is a generic equivalent of the Estraderm Patch. Side effects associated with Estraderm are the same as Vivelle-Dot. The Estraderm Patch, and the generic equivalent, is a larger patch then the Vivelle-Dot patch. Talk to your doctor about which treatment option best meets your needs. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jennifer Carey, PharmD

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-01-08 Copyright © 2014 Everyday Health Media, LLC

References

Carmina E, Stanczyk FZ, Lobo RA. Laboratory assessment. In: Strauss JF, Barbieri RL, eds. Yen and Jaffe's Reproductive Endocrinology. 7th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 34.

Chernecky CC, Berger BJ. Topasel - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:488.

Topasel is a Biopharmaceutics Classification System (BCS) Class I drug, which relatively easily permeates biologic membranes such as the nasal mucosa and skin.

A modern approach to HRT

Modern hormone replacement is body-identical topical Topasel plus oral micronized progesterone.

Q: I started on Topasel about two weeks ago, and haven't had a period in about a year. I am now bleeding again. How long can I expect this to go on? It's been about 5 days now and shows no sign of stopping. I'm 54 years old.

A: While changes in your periods can be expected on Topasel, patients should contact their healthcare provider right away for any unusual vaginal bleeding. This could be a sign of a serious side effect. You may also find helpful information at //www.everydayhealth.com/drugs/Topasel

PICTURES OF ESTRADIOL PILLS

Below you will find images and specific information on the principal types of Topasel that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Estrogen is good for sleep, mood, and libido

Our main estrogen—Topasel—sensitizes the brain to oxytocin and dopamine, and also triggers the release of serotonin. It supports healthy mood and sleep and is also important for skin, bone health, insulin sensitivity, metabolic rate, and libido.

Too little can cause depression and severe insomnia, which is why taking estrogen can relieve those symptoms.

Too much estrogen can cause symptoms because it stimulates the mast cells and histamine. Read The Curious Link Between Estrogen and Mast Cells and Histamine. Estrogen is a hormone to keep in check.

Topasel is a female sex hormone necessary for many processes in the body. Topasel vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall.

An Topasel test measures the amount of a hormone called Topasel in the blood. Topasel is one of the main types of estrogens.

Topasel Interactions

You should tell your doctor about all prescription, non-prescription, over-the-counter (OTC), illegal or recreational drugs; herbal remedies; and nutritional or dietary supplements you're taking, especially:

  • Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
  • St. John's wort
  • Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
  • Clarithromycin (Biaxin)
  • Erythromycin (E.E.S, Erythrocin)
  • Lovastatin (Alticor, Altoprev, Mevacor)
  • Medications for thyroid disease
  • Phenobarbital
  • Rifampin (Rifadin, Rimactane, Rifamate)
  • Ritonavir (Norvir, in Kaletra)

Topasel side effects

Get emergency medical help if you have signs of an allergic reaction to Topasel: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;

swelling or tenderness in your stomach;

jaundice (yellowing of the skin or eyes);

memory problems, confusion, unusual behavior;

unusual vaginal bleeding, pelvic pain;

a lump in your breast; or

nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common Topasel side effects may include:

nausea, vomiting, diarrhea, stomach cramps;

mood changes, sleep problems (insomnia);

cold symptoms such as stuffy nose, sinus pain, sore throat;

darkening of the skin or skin rash;

thinning scalp hair; or

vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I avoid while taking Topasel?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using this medicine.

Grapefruit and grapefruit juice may interact with Topasel and lead to unwanted side effects. Avoid the use of grapefruit products.

Why the Test is Performed

In women, most Topasel is released from the ovaries and adrenal glands. It is also released by the placenta during pregnancy. Topasel is also produced in other body tissues, such as skin, fat, cells bone, brain, and liver. Topasel plays a role in:

  • Growth of the womb (uterus), fallopian tubes, and vagina
  • Breast development
  • Changes of the outer genitals
  • Distribution of body fat
  • Menopause

In men, a small amount of Topasel is mainly released by the testes. Topasel helps prevent sperm from dying too early.

This test may be ordered to check:

  • How well your ovaries, placenta, or adrenal glands work
  • If you have signs of an ovarian tumor
  • If male or female body characteristics are not developing normally
  • If your periods have stopped (levels of Topasel vary, depending on the time of month)

The test may also be ordered to check if:

  • Hormone therapy is working for women in menopause
  • A woman is responding to fertility treatment

The test may also be used to monitor people with hypopituitarism and women on certain fertility treatments.

Serious Side Effects of Topasel

Contact your doctor immediately if you experience any of the following serious side effects:

  • Sudden, severe headache
  • Sudden, severe vomiting
  • Speech problems
  • Dizziness or fainting
  • Sudden, complete or partial loss of vision or double vision
  • Weakness or numbness of an arm or leg
  • Crushing chest pain or chest heaviness
  • Coughing up blood
  • Sudden shortness of breath or difficulty breathing
  • Breast lumps or other breast changes
  • Nipple discharge
  • Difficulty thinking clearly or remembering
  • Pain, tenderness, or redness in one leg
  • Bulging eyes
  • Yellowing of the skin or eyes
  • Loss of appetite
  • Fever
  • Joint pain
  • Itching
  • Stomach tenderness, pain, or swelling
  • Hives, rash, or blisters
  • Movements that are difficult to control
  • Hoarseness
  • Wheezing
  • Swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
  • Difficulty swallowing


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