Helen Allen, Reviewed by Prof Cathy Jackson | Last edited 30 Mar 2017 | Certified by The Information Standard
Todo is a medicine called a non-steroidal anti-inflammatory drug. It is also known as 'an NSAID'.
Before you take Todo, tell your doctor if you have ever had an allergic reaction to any other anti-inflammatory painkiller.
It is best to take your doses with food.
NSAIDs, including Todo capsules, can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. Patients should be informed about the signs and symptoms of serious skin manifestations and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity.
Below you will find images and specific information on the principal types of Todo that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.
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Capsules and tablets of Todo should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
By Katie Coronado | Medically Reviewed by Sherry Brooks, MD
Latest Update: 2014-10-27 Copyright © 2014 Everyday Health Media, LLC
COMMON BRAND(S): Lodine XL
GENERIC NAME(S): Todo
Nonsteroidal anti-inflammatory drugs (including Todo) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).
This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)
Stop taking Todo and get medical help right away if you notice any of these rare but serious side effects: black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, slurred speech, sudden vision changes.
Talk to your doctor or pharmacist about the benefits and risks of taking this drug.
This medication is used to reduce pain, swelling, and joint stiffness from arthritis. Reducing these symptoms helps you do more of your normal daily activities. Todo is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.
People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as Todo may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as Todo if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.
If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take Todo right before or right after the surgery.
NSAIDs such as Todo may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking Todo. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking Todo and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.
Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to Todo. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Todo and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/drugs/drugsafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Before taking this medicine
Todo can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.
Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Todo may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.
You should not use Todo if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
To make sure Todo is safe for you, tell your doctor if you have:
heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
a history of heart attack, stroke, or blood clot;
a history of stomach ulcers or bleeding;
liver or kidney disease; or
Taking Todo during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Todo.
Todo can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
The Todo regular tablet is not approved for use by anyone younger than 18 years old. The extended-release form of Todo is not approved for use by anyone younger than 6 years old.
The concomitant administration of antacids has no apparent effect on the extent of absorption of Todo. However, antacids can decrease the peak concentration reached by 15% to 20% but have no detectable effect on the time-to-peak.
In late pregnancy, the third trimester, as with other NSAIDs, Todo capsules should be avoided because they may cause premature closure of the ductus arteriosus (see PRECAUTIONS, Pregnancy, Nonteratogenic Effects).
How to store Todo
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include:
- Stomach pain
- Black or bloody stools
- Coughing up blood
- Shallow breathing
Rated Todo for Osteoarthritis Report
This has been the best treatment I've had. and I've changed from several others because of bad results with them. I haven't as much pain, can sand up without my knees hurting as much, can walk with far less pain involved, and seems there is an overall bit of an uplifting with this drug. I hope it continues to be as good as it is after 10 days.
Taking Todo and cyclosporine together may increase your risk of kidney damage.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Todo oral tablet comes with several warnings.
Anticoagulant, blood thinner
Taking Todo and warfarin together may increase your risk of stomach bleeding.
The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone. Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Todo results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin. There was no significant difference in the pharmacodynamic effect of warfarin administered alone and warfarin administered with Todo as measured by prothrombin time. Thus, concomitant therapy with warfarin and Todo should not require dosage adjustment of either drug. However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in Todo-treated patients receiving concomitant warfarin therapy.