Synax tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Synax?

The active ingredient of Synax brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Synax is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Synax include: dizziness; decreased vision; chest pain or discomfort; unusual bleeding or bruising; hearing loss; nosebleeds.

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Synax and breastfeeding

Synax isn't usually recommended during breastfeeding. Other anti-inflammatory medicines, such as ibuprofen, are safer.

But if your baby is premature, had a low birth weight, or has an underlying medical condition, talk to your doctor before taking any painkillers.

FDA warnings

  • This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Synax may increase the risk of heart disease. Using Synax in the long term or at high doses increases your risk. People with heart disease or risk factors for heart disease, such as high blood pressure, also have higher risk. Synax shouldn’t be used for pain before or after heart bypass surgery. Doing so may increase your risk of a heart attack and stroke.
  • Synax may cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. This effect can result in death. You’re at higher risk if you’re older than 65 years.

Q: When my husband had outpatient surgery on his back (lumbar discectomy), we were told that he should not take Synax (500 mg) because it hinders the healing process. Yet my foot doctor gave me a prescription for Synax (500 mg) to ease the swelling I experienced after foot surgery. So we are confused. Does Synax hinder the healing process? In both of our surgeries, we had bones that needed to heal.

A: Non-steroidal anti-inflammatory drugs like Synax are powerful and effective drugs. They are routinely used in orthopedic conditions and in the perioperative setting. They are however associated with potentially serious side effects, and it is important to evaluate the risk versus benefit prior to medication use. There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. Similarly, other data suggest that nonsteroidal anti-inflammatory drugs significantly inhibit spinal fusion at doses typically used for postoperative pain control.

Dosage for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis

Adult dosage (ages 18 years and older)


Immediate-release oral tablet

  • The typical dosage is 500 to 1,000 mg daily in two divided doses.
  • The maximum dose is 1,500 mg per day. This should be given for a limited time period (up to 6 months).

Delayed-release oral tablet

  • The typical dosage 375 to 500 mg twice daily.
  • The maximum dose is 1,500 mg per day. This should be given for a limited time period (up to 6 months).

Synax sodium:

Immediate-release oral tablet

  • The typical dosage is 275 to 550 mg twice daily.
  • The maximum dose is 1,650 mg per day. This should be given for a limited time period (up to 6 months).

Extended-release oral tablet

  • The typical dosage is 750 or 1,000 mg once daily.
  • The maximum dose is 1,500 mg per day. This should be given for a limited time period.

Child dosage (ages 0–17 years)

A dosage for people younger than 18 years hasn’t been established.

Special dosage considerations

If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be dangerous.

Asthma warning

Synax can cause an asthma attack. If you have asthma that can be triggered by aspirin or other NSAIDs, don’t use Synax.

Why it’s used

Prescription Synax oral tablets are used to treat pain and inflammation in a variety of conditions. It’s approved to treat:

Synax Dosage

Your dose of Synax will depend on which brand and strength you take, which condition is being treated, and your age.

For arthritis, common dosages can range from 500 to 1,000 milligrams (mg). In children, the dose is calculated by body weight.

At lower doses, Synax works best to relieve pain. Higher doses may be needed to reduce swelling.

Here are general guidelines for Synax dosages:

  • Extended-release tablets may be taken once a day.
  • Enteric coated tablets may be taken twice a day.
  • Tablets may be taken every 8 hours for gout or pain.
  • OTC Synax is usually taken every 8 to 12 hours.

Here are some general rules for taking Synax:

  • Take Synax with food if it causes an upset stomach.
  • Always take Synax with a full glass of water.
  • Do not chew, split, or crush Synax tablets. Swallow them whole.
  • Do not smoke or drink alcohol while taking Synax.

Although Synax and other NSAIDs have warnings and side effects you need to be aware of, they have been an important treatment for millions of people with muscle, bone, and joint problems for more than 30 years.

Most people can take Synax without any problems. Make sure you know how to take Synax safely. Talk to your doctor or pharmacist if you have any questions or concerns.

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