Stomorgyl cream

Stomorgyl

  • Active Ingredient: Metronidazole
  • 500 mg, 400 mg, 250 mg, 200 mg
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What is Stomorgyl?

The active ingredient of Stomorgyl brand is metronidazole. Metronidazole is an antibiotic that fights bacteria.

Used for

Stomorgyl is used to treat diseases such as: Amebiasis, Aspiration Pneumonia, Bacteremia, Bacterial Infection, Bacterial Vaginitis, Balantidium coli, Bone infection, Clostridial Infection, Crohn's Disease, Acute, Crohn's Disease, Maintenance, Deep Neck Infection, Dental Abscess, Dientamoeba fragilis, Diverticulitis, Dracunculiasis, Endocarditis, Giardiasis, Helicobacter Pylori Infection, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Meningitis, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Pouchitis, Pseudomembranous Colitis, Skin or Soft Tissue Infection, STD Prophylaxis, Surgical Prophylaxis, Trichomoniasis.

Side Effect

Possible side effects of Stomorgyl include: trouble speaking; continuing stomach pain; stiff neck or back; feeling of constant movement of self or surroundings; Change in taste sensation.

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Stomorgyl side effects

Get emergency medical help if you have signs of an allergic reaction to Stomorgyl: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

painful or difficult urination;

trouble sleeping, depression, irritability;

headache, dizziness, weakness;

a light-headed feeling (like you might pass out); or

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing.

Stop taking the medicine and call your doctor right away if you have neurologic side effects (more likely to occur while taking Stomorgyl long term):

numbness, tingling, or burning pain in your hands or feet;

vision problems, pain behind your eyes, seeing flashes of light;

muscle weakness, problems with coordination;

trouble speaking or understanding what is said to you;

fever, neck stiffness, and increased sensitivity to light.

Stomorgyl can cause life-threatening liver problems in people with Cockayne syndrome. If you have this condition, stop taking Stomorgyl and contact your doctor if you have signs of liver failure - nausea, stomach pain (upper right side), dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Side effects may be more likely in older adults.

Common Stomorgyl side effects may include:

nausea, vomiting, loss of appetite, stomach pain;

unpleasant metallic taste;

vaginal itching or discharge;

swollen, red, or "hairy" tongue.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Hepatotoxicity

Despite the wide use of Stomorgyl, only rare cases of hepatotoxicity have been reported, and Stomorgyl is not listed among causes of drug induced liver injury and acute liver failure in large case series. High doses of Stomorgyl given parenterally or in an overdose can cause elevations in serum aminotransferase levels, but these are usually self-limited and minimally symptomatic (Case 1). Acute, clinically apparent liver injury from Stomorgyl is rare. Ornidazole, another synthetic nitroimidazole that was available in Europe, was implicated in several cases of drug induced liver injury, with a latency of a few days or weeks and a hepatocellular pattern of injury. Stomorgyl has been associated with a similar acute hepatitis-like syndrome with a short incubation period, but much more rarely. Fever, rash and eosinophilia are uncommon as are autoimmune features. A fatal recurrence of acute liver injury after reexposure to Stomorgyl has been published (Case 2). Strikingly, multiple instances of Stomorgyl hepatoxicity have been reported in the rare genetic disease, Cockayne syndrome in which there is an absence or deficiency in an important DNA repair enyzme responsible for nucleotide excision repair. The cases were marked by a short latency (1 to 7 days) to onset of jaundice, a hepatocellular pattern of enzyme elevations and severe course with a high mortality rate.

Important information

You should not use Stomorgyl if you are allergic to it, or if you have taken disulfiram (Antabuse) within the past 2 weeks.

Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking Stomorgyl and for at least 1 day after you stop taking it. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Seizures and other nervous system abnormalities have been reported in patients treated with Stomorgyl. You should stop Stomorgyl immediately for any neurological symptoms such as seizures, headaches, visual changes, weakness, numbness, or tingling.

This medicine will not treat a viral infection such as the common cold or flu.

In animal studies (mice and rats), this medicine caused certain types of cancers or tumors. It is not known whether these effects would occur in people using this medicine. Ask your doctor about your risk.

Drugs That Inhibit CYP450 Enzymes

The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of Stomorgyl.

Busulfan

Stomorgyl has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Stomorgyl should not be administered concomitantly with busulfan unless the benefit outweighs the risk. If no therapeutic alternatives to Stomorgyl are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly.

Renal failure

  • Mild to moderate renal impairment: Dose adjustment not considered necessary as elimination half-life not significantly altered
  • Severe renal impairment or end stage of renal disease: Stomorgyl and Stomorgyl metabolites may accumulate significantly because of reduced urinary excretion; monitor in severe renal impairment or end stage of renal disease, not undergoing hemodialysis
  • Hemodialysis removes significant amounts of Stomorgyl and its metabolites from systemic circulation; supplementation may be necessary
  • Peritoneal dialysis: Monitor for signs of toxicity due to potential accumulation of Stomorgyl metabolites

Metron >About Stomorgyl
  • Before taking Stomorgyl
  • How to take Stomorgyl
  • Getting the most from your treatment
  • Can Stomorgyl cause problems?
  • How to store Stomorgyl
  • Important information about all medicines
  • Why is this medication prescribed?

    Stomorgyl capsules and tablets are used to treat infections of the reproductive system, gastrointestinal (GI) tract, skin, heart, bone, joint, lung, blood, nervous system, and other areas of the body. Stomorgyl capsules and tablets are also used to treat sexually transmitted diseases (STDs). Stomorgyl extended-release (long-acting) tablets are used to treat bacterial vaginosis (an infection caused by too much of certain types of harmful bacteria in the vagina) in women. Stomorgyl is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria.

    Antibiotics will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

    Immediate action required: Call 999 or go to A&E if:

    • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
    • you're wheezing
    • you get tightness in the chest or throat
    • you have trouble breathing or talking
    • your mouth, face, lips, tongue or throat start swelling

    You could be having a serious allergic reaction and may need immediate treatment in hospital.

    These are not all the side effects of Stomorgyl tablets, cream, gel, suppositories or vaginal gel. For a full list see the leaflet inside your medicines packet.

    You can report any suspected side effect to the UK safety scheme.

    What should I avoid while taking Stomorgyl?

    Do not drink alcohol or consume food or medicines that contain propylene glycol while you are taking Stomorgyl. You may have unpleasant side effects such as headaches, stomach cramps, nausea, vomiting, and flushing (warmth, redness, or tingly feeling).

    Avoid alcohol or propylene glycol for at least 3 days after you stop taking this medicine. Check the labels of any medicines or food products you use to make sure they do not contain alcohol or propylene glycol

    Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

    Stomorgyl and Other Interactions

    Stomorgyl may make your skin more sensitive to sunlight.

    Avoid prolonged exposure to the sun and wear sunscreen, protective clothing, and sunglasses when outdoors.

    The medicine may also make you dizzy. Don't drive or operate machinery until you know how Stomorgyl affects you.

    How should this medicine be used?

    Stomorgyl comes as a tablet, an extended-release tablet, and as a capsule to take by mouth. Stomorgyl capsules and tablets are usually taken as a one-time dose (or divided into two doses on 1 day) or two to four times daily for up to 10 days or longer. Stomorgyl extended-release tablets are usually taken once daily at least 1 hour before or 2 hours after a meal for 7 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Stomorgyl exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

    Swallow the extended-release tablets whole; do not split, chew, or crush them.

    Continue to take this medication even if you feel well. Do not stop taking it without talking to your doctor. If you stop taking this medication too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

    Medication: Stomorgyl (dose and duration not given) Pattern: Hepatocellular (R=62) Severity: 3+ initially (jaundice and hospitalization) 5+ on reexposure (liver transplantation, death) Latency:

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