Safenac-TR tablets

Safenac-TR

  • Active Ingredient: Diclofenac
  • 100 mg
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What is Safenac-TR?

The active ingredient of Safenac-TR brand is diclofenac. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. The inactive ingredients in Diclofenac sodium delayed-release tablets include: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium starch glycolate, talc, titanium dioxide, triethyl citrate.

Used for

Safenac-TR is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Frozen Shoulder, Migraine, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica, Spondyloarthritis.

Side Effect

Possible side effects of Safenac-TR include: belching; itching skin or rash; slow or fast heartbeat; weight loss; muscle twitching; pain or discomfort in the chest, upper stomach, or throat; cloudy urine.

How to Buy Safenac-TR tablets online?

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Rare Side Effects

In severe cases, Safenac-TR may cause a deadly liver condition known as fatal fulminant hepatitis.

Get medical help if you have any yellowing or graying of the skin or eyes, if your lower extremities or abdomen is swelling, if you are extra sleepy, or become confused.

Q: Which is preferred for toothache Safenac-TR sodium or potassium?

A: Voltaren, Cataflam (Safenac-TR) (///www.everydayhealth.com/drugs/Safenac-TR) is a non-steroidal anti-inflammatory drug (NSAID) that works on substances in the brain that normally cause pain and inflammation. Safenac-TR can be used for headaches, toothaches, and joint pain associated with arthritis. Safenac-TR is available in a potassium and sodium salt form. Both forms are effective but the doctor needs to determine which drug is more effective for your condition. (//www.everydayhealth.com/pain-management/pain-treatment.aspx). When your doctor prescribes a new medication, be sure to discuss all your prescription medications and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals and herbals, as well as foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescriptions and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD

Rated Safenac-TR for Osteoarthritis Report

I didn't find this drug to help me at all. I have torn tendons in my maxi and mid glut, arthritis in my hip and lower back pain. I think the doctor gave this drug to me so it wouldn't work and I would come back to him. Ultimately, he mentioned surgery on my back. I am seeing another doctor. Doctors see $$ signs inn this area. Not helping the patient to live a mobile life.

How to use Safenac-TR Sodium

Read the Medication Guide provided by your pharmacist before you start using Safenac-TR and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with a full glass of water (8 ounces / 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. If you experience stomach upset with this medication, you may take it with food, milk, or an antacid. However, this may slow absorption and delay pain relief, especially if you are not taking this medication on a regular schedule.

Swallow this medication whole. Do not crush, chew, or break the tablets. Doing so can destroy the special coating on the tablet and may increase side effects.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

For certain conditions (such as arthritis), it may take up to 2 weeks of regular use before the full benefits of this drug take effect.

If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition worsens.

Warnings for people with certain health conditions

For people with high blood pressure or water retention: Tell your doctor before using Safenac-TR. Your heart may already be working hard, and adding an NSAID can increase this workload.

For people with ulcer or digestive bleeding: If you’ve had an ulcer or bleeding from your digestive system, ask your doctor before using Safenac-TR. You’re at increased risk for another bleed.

For people with kidney disease or taking diuretics: If you have kidney disease or take diuretics (water pills), there’s a risk this drug can affect your kidneys’ ability to remove excess water from your body. Ask your doctor if Safenac-TR is the right drug for you.

For people with asthma and aspirin reactions: If you have asthma and you react to aspirin, you could have a bad reaction to Safenac-TR. Talk to your doctor before using the drug.

Safenac-TR suppositories

Suppositories are medicine that you push gently into your back passage (anus).

  • Go to the toilet beforehand if you need to.
  • Wash your hands before and after using the medicine. Also clean around your back passage with mild soap and water, rinse and pat dry.
  • Unwrap the suppository.
  • Gently push the suppository into your back passage (anus) with the pointed end first. It needs to go in about 3 centimetres (1 inch).
  • Sit or lie still for about 15 minutes. The suppository will melt inside your back passage. This is normal.

Difference between Safenac-TR and Ibuprofen

Both drugs are classified as NSAID – nonsteroidal anti-inflammatory drugs and used with efficacy for the treatment of pain. They work by lowering the levels of hormones (prostaglandins) that are responsible for causing inflammation and pain in the body.

Dosage and formulations

  • Before you start taking Safenac-TR, read the manufacturer's printed information leaflet from ins >

Mechanism Of Action

Safenac-TR has analgesic, anti-inflammatory, and antipyretic properties.

The mechanism of action of VOLTAREN, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2).

Safenac-TR is a potent inhibitor of prostaglandin synthesis in vitro. Safenac-TR concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Safenac-TR is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Safenac-TR is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. However, due to first-pass metabolism, only about 50% of the absorbed dose is systemically available (see Table 1). Food has no significant effect on the extent of Safenac-TR absorption. However, there is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of PK Parameter Normal Healthy Adults (20-48 years) Mean Coefficient of Mean Variation (%) Absolute Bioavailability (%) 55 40 Tmax (hr) 2.3 69 Oral Clearance (CL/F; mL/min) 582 23 Renal Clearance (% unchanged drug in urine)

What is the dosage for Safenac-TR?

Safenac-TR should be taken with food to reduce stomach upset. The recommended dose for most conditions is 100-200 mg daily. Dosing intervals are 2 to 4 times daily depending on the Safenac-TR formulation used and the condition being treated.

Serious Skin Reactions

NSAIDs, including Safenac-TR, can cause serious skin adverse reactions such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. Inform patients about the signs and symptoms of serious skin reactions and to discontinue the use of VOLTAREN at the first appearance of skin rash or any other sign of hypersensitivity. VOLTAREN is contraindicated in patients with previous serious skin reactions to NSAIDs (see CONTRAINDICATIONS).

Immunosuppressant drug

Taking cyclosporine, a drug that weakens your immune system, with Safenac-TR may increase your risk for kidney problems.

DOSAGE AND ADMINISTRATION

Carefully consider the potential benefits and risks of VOLTAREN ® (Safenac-TR sodium enteric-coated tablets) and other treatment options before deciding to use VOLTAREN. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS; Gastrointestinal Bleeding, Ulceration, And Perforation).

After observing the response to initial therapy with VOLTAREN, the dose and frequency should be adjusted to suit an individual patient’s needs.

For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses (50 mg twice a day or three times a day, or 75 mg twice a day).

For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses (50 mg three times a day. or four times a day, or 75 mg twice a day.).

For the relief of ankylosing spondylitis, the recommended dosage is 100-125 mg/day, administered as 25 mg four times a day, with an extra 25-mg dose at bedtime if necessary.

Different formulations of Safenac-TR are not necessarily bioequivalent even if the milligram strength is the same.

What brand names are available for Safenac-TR?

Voltaren, Cataflam, Voltaren-XR, Cambia, Zipsor, Zorvolex

2. Key facts

  • Take Safenac-TR tablets or capsules with a meal or snack, or just after eating.
  • It's best to take the lowest dose of Safenac-TR for the shortest time to control your symptoms.
  • The most common side effects are headaches, dizziness, stomach pain, feeling or being sick, diarrhoea and rashes.
  • Safenac-TR tablets come as either Safenac-TR potassium or Safenac-TR sodium. They work as well as each other.
  • Safenac-TR is also called by the brand names Voltarol, Dicloflex, Econac and Fenactol.

Precautions

See also Warning section.

Before taking Safenac-TR, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), bleeding or clotting problems, heart disease (such as previous heart attack), high blood pressure, liver disease, growths in the nose (nasal polyps), stomach/intestinal/esophagus problems (such as bleeding, ulcers, recurring heartburn), stroke.

Kidney problems can sometimes occur with the use of NSAID medications, including Safenac-TR. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding, kidney problems, and worsening heart problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Primary dysmenorrhea (painful menstrual period)

The immediate release forms of Safenac-TR are usually dosed 3 to 4 times a day and start at a dose of 25 mg.

The extended-release form is usually dosed once a day. The dose often starts at 75 mg per day.

Dosage for people younger than 18 years has not been established.

Seniors: If you are aged 65 years and older, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug does not build up in your body. Too much of the drug in your body can be toxic.

Anaphylactic Reactions

Safenac-TR has been associated with anaphylactic reactions in patients with and without known hypersensitivity to Safenac-TR and in patients with aspirin-sensitive asthma (see CONTRAINDICATIONS, WARNINGS;Exacerbation Of Asthma Related To Aspirin Sensitivity).


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