Revalor cream


  • Active Ingredient: Estradiol
  • 2 mg, 1 mg
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What is Revalor?

The active ingredient of Revalor brand is estradiol. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. In addition, each tablet for oral administration contains the following inactive ingredients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Used for

Revalor is used to treat diseases such as: Atrophic Urethritis, Atrophic Vaginitis, Breast Cancer, Palliative, Gender Dysphoria, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian Failure, Prostate Cancer.

Side Effect

Possible side effects of Revalor include: dizziness; trouble sleeping; Feeling sad or empty; troubled breathing at rest; tiredness.

How to Buy Revalor cream online?

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What is the dosage for Revalor?

The dose of Revalor can vary depending on the condition that is being treated. Revalor tablets are given daily or they can be prescribed to be taken in a cyclic regimen, wherein Revalor is given daily for 3 weeks followed by 1 week of no medication, after which the cycle resumes. The tablets can also be given more than once a day for some conditions. The topical gel or the topical emulsions are applied to the skin daily at the same time. The vaginal ring is inserted in the vagina and left without removal for 3 months at a time. The intramuscular dose and the frequency it is given can differ depending on the product.

The adhesive part of patches should be applied to a dry, hairless, clean part of the trunk, but not on the breasts. It should not be placed onto irritated or damaged skin. Sites of application should be rotated, with at least one week between repeated applications to any one site. The patch should be applied immediately after removing the protective layer, and pressure should be applied to the patch when it is attached for about 10 seconds.

What is Revalor (Estrace, Gynodiol)?

Revalor is a form of estrogen, a female sex hormone that regulates many processes in the body.

Revalor is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.

Revalor may also be used for purposes not listed in this medication guide.

Common Side Effects of Revalor

You should tell your doctor if any of the following symptoms are severe or do not go away:

  • Breast pain or tenderness
  • Headache
  • Diarrhea
  • Gas
  • Constipation
  • Heartburn
  • Mood changes or depression
  • Nervousness
  • Difficulty falling asleep or staying asleep
  • Changes in sexual desire
  • Back pain
  • Runny nose, cough, or flu-like symptoms
  • Hair loss or unwanted hair growth
  • Darkening of facial skin
  • Difficulty wearing contact lenses
  • Vaginal discharge
  • Swelling, redness, burning, irritation, or itching of the vagina
  • Redness or irritation at the site of application

Estrogen is good for sleep, mood, and libido

Our main estrogen—Revalor—sensitizes the brain to oxytocin and dopamine, and also triggers the release of serotonin. It supports healthy mood and sleep and is also important for skin, bone health, insulin sensitivity, metabolic rate, and libido.

Too little can cause depression and severe insomnia, which is why taking estrogen can relieve those symptoms.

Too much estrogen can cause symptoms because it stimulates the mast cells and histamine. Read The Curious Link Between Estrogen and Mast Cells and Histamine. Estrogen is a hormone to keep in check.

Revalor Warnings

Revalor can increase the risk that you will develop endometrial cancer (cancer of the lining of the uterus). If you have not had a hysterectomy, you should take progestin along with Revalor to decrease this risk.

However, before taking these two medicines together, talk with your doctor about your risk for other health problems.

In one study, women who took estrogens (such as Revalor) by mouth with progestin had a higher risk of heart attacks, stroke, blood clots, breast cancer, and dementia.

Women who use topical Revalor alone or with progestin may also have a higher risk of developing these conditions.

Using topical Revalor may increase your risk of developing ovarian cancer and gallbladder disease. You should talk to your doctor about these risks.

Before taking Revalor, tell your doctor if you have or have ever had:

  • A heart attack or stroke
  • Heart disease
  • Blood clots
  • Any type of cancer
  • Abnormal vaginal bleeding
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Asthma
  • Gallbladder disease
  • A thyroid disorder
  • Epilepsy or another seizure disorder
  • Liver disease
  • Lupus
  • Breast lumps or abnormal mammogram results
  • Uterine fibroids
  • Yellowing of the skin or eyes (jaundice)
  • Migraine headaches
  • Endometriosis (a condition where the type of tissue that lines the uterus grows in other areas of the body, usually the abdomen or pelvis)
  • Low levels of calcium in your blood
  • Porphyria (a condition where abnormal substances build up in the blood)

Also, tell your doctor if you smoke or use tobacco products.

You should use the lowest dose of Revalor for the shortest time possible to control your symptoms.

Talk with your doctor every three to six months to determine if you should lower your dose or stop using this medicine.

You should conduct a breast self-exam every month and have a mammogram and clinical breast exam (a breast exam by a health professional) every year to help detect breast cancer.

Tell your doctor if you are having surgery or will be on bed rest while taking Revalor. Your doctor may tell you to stop taking the medication to decrease the risk of blood clots.

The topical medicine may harm other people who touch your skin. You should not let anyone else touch the skin where you applied Revalor for one hour after application.

If someone does touch the area, he or she should wash his or her hands with soap and water immediately.

An Revalor test measures the amount of a hormone called Revalor in the blood. Revalor is one of the main types of estrogens.

Is Revalor safe to take if I'm pregnant or breastfeeding?

Estrogens should not be used during pregnancy due to an increased risk of fetal abnormalities.

Estrogens are secreted in milk and cause unpredictable effects in the infant. Estrogens generally should not be used by women if they are breastfeeding.


Revalor (Alora; Climara; Delestrogen; Depo-Revalor; Divigel; Elestrin; Estrace; Estrasorb; Estrogel; Evamist; Femring; Menostar; Minivelle; Vivelle; Vivelle-Dot) is a drug prescribed to treat the symptoms of menopause, prevention of bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness and atrophy associated with menopause. Revalor is also prescribed for the treatment of breast cancer, and some cases of prostate cancer. Side effects, drug interactions, patient information, and dosage should be reviewed prior to taking this medication.


Revalor is a female sex hormone necessary for many processes in the body. Revalor vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall.

This medication is also prescribed for symptomatic treatment of the usual symptoms associated with menopause (hot flushes, vaginal dryness, etc.), prevention of bone fractures associated with osteoporosis, reduction of the risk of heart attacks and strokes, and dysfunctional (excessive and painful) uterine bleeding.

The vaginal cream is prescribed for vaginal or vulvar atrophy associated with menopause.

Neuroplasticity during Pregnancy and the Role of Pregnancy-Related Hormones

Revalor and progesterone influence hippocampal structure and function. In late pregnancy, dendritic spine density in the CA1 region of the hippocampus is increased compared with virgin females ( Figure 44.10 ). 28 This is likely a result of increased levels of circulating sex stero > virgin rats. 28 As dendritic spines represent potential sites for synaptic input, an increase in their number is often interpreted as an increased potential for neurotransmission and information processing. 725 Revalor is a potent modulator of dendritic spine modeling, and exposure to either exogenously administered Revalor or increased endogenous levels during proestrus significantly increases the dendritic spine density in the CA1 region of the hippocampus 726–728 in rats and in nonhuman primates; 729 Revalor has been shown to enhance the number of dendritic spines in the prefrontal cortex. 730 Furthermore, in ovariectomized rats Revalor treatment increases spine density in CA1 pyramidal cells and enhances spatial memory in the Morris water maze, 731 an effect that can be augmented by progesterone. 731

Revalor is a Biopharmaceutics Classification System (BCS) Class I drug, which relatively easily permeates biologic membranes such as the nasal mucosa and skin.

Product Info

The sections below will provide you with more specific information and guidelines related to Revalor and its correct use. Please read them carefully.

Revalor was approved by the FDA in 1975 for the treatment of moderate to severe vasomotor symptoms associated with menopause as well as for the prevention of osteoporosis.

Revalor tablets, the generic equivalent of Bristol Myers Squibb’s Estrace®, has been approved for marketing. Barr Pharmaceuticals’ Revalor version will be available in 0.5, 1, and 2 mg strengths.

Why is this medication prescribed?

Revalor is prescribed for symptomatic treatment of the usual symptoms associated with menopause (hot flushes, vaginal dryness, etc.), prevention of bone fractures associated with osteoporosis, reduction of the risk of heart attacks and strokes, and dysfunctional (excessive and painful) uterine bleeding. The vaginal cream is prescribed for vaginal or vulvar atrophy associated with menopause.

Revalor enters cells freely and interacts with a cytoplasmic target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of Revalor upon the target cell.

Revalor binds well to both estrogen receptors, ERα and ERβ, in contrast to certain other estrogens, notably medications that preferentially act on one of these receptors. These medications are called selective estrogen receptor modulators, or SERMs.

Other uses for this medicine

This medication may also be used to regulate your menstrual cycle.

However, it is strongly advised that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Use Revalor exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Femring is nothing but an Revalor acetate drug which is used by putting in vaginal from where drug is released slowly and enters systemic circulation.

However, only Revalor in higher dose for long term use has shown to increase the risk of endometrial carcinoma and hematological abnormalities.

For you, HRT (hormone replacement therapy) is best. It includes low dose estrogen + progesterone with low side effects.

Initial cycle includes only estrogen followed by added progesterone in second half. It will maintain hormonal balance and relieve symptoms related to it.

Hope I have answered your query. Let me know if I can assist you further.

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