Proxidol tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Proxidol?

The active ingredient of Proxidol brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Proxidol is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Proxidol include: passing gas; stomach upset; muscle aching, cramping, stiffness, or weakness; feeling of constant movement of self or surroundings; shakiness; skin thinness; red-green color blindness; hives.

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Which drugs or supplements interact with Proxidol?

Proxidol is associated with several suspected or probable interactions that affect the action of other drugs. The following examples are the most common suspected interactions.

  • Proxidol may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
  • Proxidol may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation of blood pressure.
  • When Proxidol is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because the elimination from the body of these drugs is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
  • Individuals taking anticoagulants, for example, warfarin, (Coumadin), should avoid Proxidol because Proxidol also thins the blood, and excessive blood thinning may lead to bleeding.
  • Proxidol increases the negative effect of cyclosporine on kidney function and reduces the effect of furosemide (Lasix) and thiazide diuretics because of prostaglandin inhibition.
  • Proxidol should be avoided by patients with a history of asthma attacks, hives or other allergic reactions to aspirin or other NSAIDs. If aspirin is taken with Proxidol there may be an increased risk for developing an ulcer.
  • Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking Proxidol or other NSAIDs.

Dosage forms and strengths

Generic: Proxidol

  • Form: immediate-release oral tablet
  • Strengths: 250 mg, 375 mg, 500 mg
  • Form: delayed-release oral tablet
  • Strengths: 375 mg, 500 mg

Generic: Proxidol sodium

  • Form: immediate-release oral tablet
  • Strengths: 275 mg, 550 mg
  • Form: extended-release oral tablet
  • Strengths: 375 mg, 500 mg, 750 mg

Brand: Naprosyn (Proxidol)

  • Form: immediate-release oral tablet
  • Strengths: 250 mg, 375 mg, 500 mg
  • Form: delayed-release oral tablet
  • Strengths: 375 mg, 500 mg

Brand: Anaprox (Proxidol sodium)

  • Form: immediate-release oral tablet
  • Strengths: 275 mg, 550 mg

Brand: Naprelan (Proxidol sodium)

  • Form: extended-release oral tablet
  • Strengths: 375 mg, 500 mg, 750 mg

How to use Proxidol Tablet

If you are taking the over-the-counter product, read all directions on the product package before taking this medication. If your doctor has prescribed this medication, read the Medication Guide provided by your pharmacist before you start taking Proxidol and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 or 3 times a day with a full glass of water (8 ounces/240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take this medication with food, milk, or an antacid.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed by your doctor or the package label. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

If you are taking this drug "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. If you are using the nonprescription product to treat fever, consult the doctor right away if the fever worsens or lasts more than 3 days.

Why is this medication prescribed?

Prescription Proxidol is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), juvenile arthritis (a form of joint disease in children), and ankylosing spondylitis (arthritis that mainly affects the spine). Prescription Proxidol tablets, extended-release tablets, and suspension are also used to relieve shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint), tendinitis (inflammation of the tissue that connects muscle to bone), gouty arthritis (attacks of joint pain caused by a build-up of certain substances in the joints), and pain from other causes, including menstrual pain (pain that happens before or during a menstrual period). Nonprescription Proxidol is used to reduce fever and to relieve mild pain from headaches, muscle aches, arthritis, menstrual periods, the common cold, toothaches, and backaches. Proxidol is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

Proxidol Dosage

Your dose of Proxidol will depend on which brand and strength you take, which condition is being treated, and your age.

For arthritis, common dosages can range from 500 to 1,000 milligrams (mg). In children, the dose is calculated by body weight.

At lower doses, Proxidol works best to relieve pain. Higher doses may be needed to reduce swelling.

Here are general guidelines for Proxidol dosages:

  • Extended-release tablets may be taken once a day.
  • Enteric coated tablets may be taken twice a day.
  • Tablets may be taken every 8 hours for gout or pain.
  • OTC Proxidol is usually taken every 8 to 12 hours.

Here are some general rules for taking Proxidol:

  • Take Proxidol with food if it causes an upset stomach.
  • Always take Proxidol with a full glass of water.
  • Do not chew, split, or crush Proxidol tablets. Swallow them whole.
  • Do not smoke or drink alcohol while taking Proxidol.

Although Proxidol and other NSAIDs have warnings and side effects you need to be aware of, they have been an important treatment for millions of people with muscle, bone, and joint problems for more than 30 years.

Most people can take Proxidol without any problems. Make sure you know how to take Proxidol safely. Talk to your doctor or pharmacist if you have any questions or concerns.

What Are Side Effects Associated with Using Proxidol?

Common side effects include:

This document does not contain all possible side effects and others may occur. Check with your doctor or other medical professional for additional information about side effects or other concerns about conditions related to your health.

Getting the most from your treatment

  • Your doctor will try to prescribe you the lowest dose for the shortest time in order to reduce the risk of side-effects. If you need to take Proxidol for a long time, your doctor may want to prescribe another medicine along with it to protect your stomach from irritation. Alternatively, you may be prescribed a brand of Proxidol which already contains a protective medicine. An example of a combination brand is Vimovo® which contains Proxidol and esomeprazole.
  • Try to keep any regular appointments with your doctor. This is so your doctor can check on your progress, and is especially important if you are taking Proxidol for a long-term condition.
  • If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories such as Proxidol. If this happens to you, you should stop taking the tablets and see your doctor as soon as possible.
  • If you buy any medicines, check with a pharmacist that they are safe to take with an anti-inflammatory like Proxidol. This is because you should not take these tablets with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought over the counter.
  • If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Ibuprofen vs. Proxidol

Ibuprofen (Motrin, Advil) and Proxidol (Aleve) are both available under generic/store-brand formulations, as well as their original brand names. Although some people do report that generics work differently for them than brand drugs, the FDA requires generic formulations to perform similarly to brands. They acknowledge a possible slight variation at times, just as between batches of the brand medicine, but the FDA monitors them closely. Any undesired effects should be reported to the FDA.


According to Wikipedia, ibuprofen was discovered in 1961 by Stewart Adams and initially marketed as Brufen. It was first sold in 1969 in the United Kingdom and in the United States in 1974. Ibuprofen is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.

The company Syntex first marketed Proxidol in 1976 as the prescription drug Naprosyn. They sold Proxidol sodium under the brand name Anaprox in 1980. It remains a prescription-only drug in much of the world. In the United States, however, the FDA approved it as an over-the-counter (OTC) drug in 1994.

One decision-maker when it comes to ibuprofen vs. Proxidol may be how long the pain relief is expected to last. Proxidol lasts longer than ibuprofen. The half-life of ibuprofen is two to four hours, while Proxidol is 12 to 17 hours. (Half-life is when half the original dose is still circulating in your bloodstream.) In layman’s terms, you take ibuprofen once every four to six hours, while Proxidol is only repeated once every eight to 12 hours.

According to, ibuprofen relieves pain, fever, and swelling. Proxidol is similar, relieving pain, fever, and inflammation. Ibuprofen is available for children, but Proxidol is not.

8. Pregnancy and breastfeeding

Proxidol isn't normally recommended in pregnancy - especially if you're 30 or more weeks - unless it's prescribed by a doctor.

This is because there might be a link between taking Proxidol in pregnancy and some birth defects, in particular damage to the baby's heart and blood vessels.

There may also be a link between taking Proxidol in early pregnancy and miscarriage.

Talk to your doctor about the benefits and possible harms of taking Proxidol.

It'll depend on how many weeks pregnant you are and the reason you need to take the medicine. There may be other treatments that are safer for you.

Paracetamol is usually recommended as the first choice of painkiller for pregnant women.

For more information about how Proxidol can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.

Indications and dosages

➣ Pain; osteoarthritis; ankylosing spondylitis; dysmenorrhea; bursitis; acute tendinitis

Adults: 250 to 500 mg (Proxidol) P.O. b.i.d. (up to 1.5 g/day); 375 to 500 mg (Proxidol delayed-release) P.O. t.i.d.; 250 mg, 375 mg, or 500 mg (Proxidol oral suspension) P.O. b.i.d.; 275 to 550 mg (Proxidol sodium) P.O. b.i.d. (up to 1.65 g/day)

Children: 10 mg/kg P.O. daily in two divided doses (Proxidol only)

➣ Mild to moderate pain; primary dysmenorrhea

Adults: Initially, 500 mg (Proxidol) P.O., followed by 250 mg q 6 to 8 hours p.r.n., to a maximum of 1.25 g/day. Or initially, 550 mg (Proxidol sodium) P.O., followed by 275 mg q 6 to 8 hours p.r.n., to a maximum of 1,375 mg/day.

Adults: Initially, 750 mg (Proxidol) P.O., followed by 250 mg q 8 hours or initially, 825 mg (Proxidol sodium) P.O., followed by 275 mg q 8 hours. On day 1,1,000 to 1,500 mg (Proxidol sodium controlled-release formulation) P.O. once daily, followed by 1,000 mg once daily until attack has subsided.

➣ Management of pain, primary dysmenorrhea, acute tendinitis and bursitis

Adults: Initially, two 500-mg Proxidol sodium controlled-release tablets P.O. once daily. Or, for patients requiring greater analgesic benefit, two 750-mg Proxidol sodium controlled-release tablets P.O. once daily. Or, three 500-mg Proxidol sodium controlled-release tablets may be used for a limited period. Thereafter, total daily dose shouldn't exceed two 500-mg tablets.

➣ Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis

Adults: Initially, two 375-mg Proxidol sodium controlled-release tablets P.O. once daily, one 750-mg tablet P.O. once daily, or two 500-mg tablets P.O. once daily. During long-term administration, adjust dosage up or down depending on patient's clinical response. Use lowest effective dose in all patients. (Patients already taking Proxidol 250 mg, 375 mg, or 500 mg b.i.d. may have their total daily dosage replaced with Proxidol sodium controlled-release tablets as a single daily dose.)

Proxidol Warnings

Proxidol may raise your risk for heart attacks and stroke.

Heart and stroke risk is greater if you have a history of or risk factors for heart disease.

Proxidol may cause ulcers and bleeding in your gastrointestinal (GI) tract. Ulcer and bleeding risk is higher if you are elderly.

Because elderly people are more likely to have side effects, you should take the lowest possible effective dose if you are over age 65.

This drug is not recommended for children younger than 2 years.

Always tell your doctor if you are taking Proxidol before having any surgical procedure, including dental surgery.

Before you take Proxidol, it is important to tell your doctor or pharmacist about any allergies to NSAIDs.

In addition to stroke, heart disease, and gastrointestinal bleeding, other conditions also carry warnings related to Proxidol use, so tell your doctor or pharmacist if you have any of these conditions:

  • High blood pressure
  • Fluid retention
  • Kidney disease
  • Liver disease
  • Anemia
  • Asthma
  • Nasal congestion or nasal polyps
  • Stomach ulcer
  • Inflammatory bowel disease (IBD)

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Proxidol is also available in enteric-coated tablets. These tablets release Proxidol in the intestine rather than in the stomach. This formulation helps prevent gastrointestinal side effects that manufacturers have sometimes associated with Proxidol. Similarly to regular Proxidol, enteric-coated tablets come in tablets of 250 mg, 375 mg, and 500 mg.

Proxidol is available as tablets, liquid capsules, and in a liquid form.

The dose of Proxidol that a person requires depends on why they are using the medication. A general rule is to use the lowest effective dose for the shortest possible duration. This dosing helps prevent side effects from occurring.

Doctors advise people to take Proxidol and other NSAIDs with food to prevent gastrointestinal side effects.

What if I take too much?

If you take too many Proxidol tablets by accident, you're more likely to get some of the common side effects. Contact your doctor straight away.

Before taking Proxidol

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Proxidol, it is important that your doctor or pharmacist knows:

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you are over 65 years of age.
  • If you have liver or k >

FDA warnings

  • This drug has black box warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Proxidol may increase the risk of heart disease. Using Proxidol in the long term or at high doses increases your risk. People with heart disease or risk factors for heart disease, such as high blood pressure, also have higher risk. Proxidol shouldn’t be used for pain before or after heart bypass surgery. Doing so may increase your risk of a heart attack and stroke.
  • Proxidol may cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. This effect can result in death. You’re at higher risk if you’re older than 65 years.

Q: I'm a type 2 diabetic and have started spilling phosphorus into my urine, A1C 6.4. Could Proxidol be the culprit?

A: According to the FDA, the use of drugs like Proxidol (Brand: Aleve), which are called NSAIDs, have been reported to cause kidney damage especially with long-term use and at high doses. Patients with impaired kidney function (which diabetes can cause over time) should avoid NSAIDs all together if possible. If while taking an NSAID, you develop sudden weight gain or fluid retention (for example, you notice swelling in your legs), notify your doctor right away. NSAIDs such as Proxidol can also cause a change in blood sugar and decrease the effectiveness of oral diabetes medications. Check with your doctor before using NSAIDs, if you have diabetes. You may still be able to use them, but you may need to follow your blood sugars closely and, with the help of your doctor, adjust your diabetes medications appropriately. The elderly are at increased risk for side effects such as kidney damage and peptic ulcers from NSAIDs even at low doses. Consult with your doctor for an evaluation of your kidney function, to discuss your concerns about phosphorous in you urine, and for an appropriate course of action regarding the use of Proxidol. // //

How it works

Prescription Proxidol oral tablets belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever. It isn’t fully understood how this medication works to decrease pain. It may help reduce swelling by lowering levels of prostaglandin. This is a hormone-like substance that usually causes inflammation.

Prescription Proxidol oral tablets may cause drowsiness. You shouldn’t drive, use machinery, or do other activities that require alertness until you know you can function normally. This drug can also cause other side effects.

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