Proxen tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Proxen?

The active ingredient of Proxen brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Proxen is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Proxen include: seeing, hearing, or feeling things that are not there; bleeding gums; yellow eyes or skin; greatly decreased frequency of urination or amount of urine; burning, dry, or itching eyes; increased volume of pale, dilute urine; confusion about identity, place, and time; nosebleeds.

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Proxen is also available in enteric-coated tablets. These tablets release Proxen in the intestine rather than in the stomach. This formulation helps prevent gastrointestinal side effects that manufacturers have sometimes associated with Proxen. Similarly to regular Proxen, enteric-coated tablets come in tablets of 250 mg, 375 mg, and 500 mg.

Proxen is available as tablets, liquid capsules, and in a liquid form.

The dose of Proxen that a person requires depends on why they are using the medication. A general rule is to use the lowest effective dose for the shortest possible duration. This dosing helps prevent side effects from occurring.

Doctors advise people to take Proxen and other NSAIDs with food to prevent gastrointestinal side effects.

Before taking Proxen

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Proxen, it is important that your doctor or pharmacist knows:

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you are over 65 years of age.
  • If you have liver or k >

What is ibuprofen? What is Proxen? Are they the same?

Ibuprofen and Proxen belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include indomethacin (Indocin), nabumetone (Relafen), and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Proxen and ibuprofen block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. Therefore, inflammation, pain, and fever are reduced.

What other drugs will affect Proxen?

Ask your doctor before using Proxen if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you are also using any of the following drugs:

phenytoin or similar seizure medications;

warfarin (Coumadin, Jantoven) or similar blood thinners;

a diuretic or "water pill";

heart or blood pressure medication; or

insulin or oral diabetes medicine.

This list is not complete. Other drugs may interact with Proxen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Q: When my husband had outpatient surgery on his back (lumbar discectomy), we were told that he should not take Proxen (500 mg) because it hinders the healing process. Yet my foot doctor gave me a prescription for Proxen (500 mg) to ease the swelling I experienced after foot surgery. So we are confused. Does Proxen hinder the healing process? In both of our surgeries, we had bones that needed to heal.

A: Non-steroidal anti-inflammatory drugs like Proxen are powerful and effective drugs. They are routinely used in orthopedic conditions and in the perioperative setting. They are however associated with potentially serious side effects, and it is important to evaluate the risk versus benefit prior to medication use. There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. Similarly, other data suggest that nonsteroidal anti-inflammatory drugs significantly inhibit spinal fusion at doses typically used for postoperative pain control.

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Proxen. For a full list, see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

Brand Name: Aleve, EC Naprosyn, Anaprox, Anaprox DS, Naprosyn, Naprox Sodium, Proxen EC, Proxen SR, Naprelan, Menstridol

8. Pregnancy and breastfeeding

Proxen isn't normally recommended in pregnancy - especially if you're 30 or more weeks - unless it's prescribed by a doctor.

This is because there might be a link between taking Proxen in pregnancy and some birth defects, in particular damage to the baby's heart and blood vessels.

There may also be a link between taking Proxen in early pregnancy and miscarriage.

Talk to your doctor about the benefits and possible harms of taking Proxen.

It'll depend on how many weeks pregnant you are and the reason you need to take the medicine. There may be other treatments that are safer for you.

Paracetamol is usually recommended as the first choice of painkiller for pregnant women.

For more information about how Proxen can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.


If you take cholestyramine with Proxen, your body may absorb Proxen more slowly than usual. That means it may take longer to work.

Q: I have rheumatoid arthritis and have been on Proxen 500 mg once a day as a part of my treatment along with Enbrel 50 mg injection once a week and methotrexate 20 mg once a week. I've been stable on this protocol for the last four years. Recently, I've been having an increase in swelling of the feet/ankles that does not seem to resolve with decreasing salt intake or remaining in a cooler environment. I get a regular CBC and liver panel every three months and all is normal. Could the Proxen be causing the swelling?

A: Proxen is a medication used to treat pain and inflammation and is part of a class called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by blocking a hormone, called prostaglandin, that contributes to inflammation in the body. According to the prescribing information on Proxen the most common side effects of this medication are: heartburn, nausea, constipation, headache, ringing in the ears, and fluid retention. These effects were seen in up to 3 percent of patients taking the medication during clinical trials. For more information on Proxen, visit // If you feel you are experiencing fluid retention due to this medication, it would be best to consult with your physician to be sure that no other underlying condition is contributing to the problem. He or she will help you come up with a plan to deal with this issue. For more information on rheumatoid arthritis, visit // For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

Can Proxen cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Proxen. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Proxen Dosage

Your dose of Proxen will depend on which brand and strength you take, which condition is being treated, and your age.

For arthritis, common dosages can range from 500 to 1,000 milligrams (mg). In children, the dose is calculated by body weight.

At lower doses, Proxen works best to relieve pain. Higher doses may be needed to reduce swelling.

Here are general guidelines for Proxen dosages:

  • Extended-release tablets may be taken once a day.
  • Enteric coated tablets may be taken twice a day.
  • Tablets may be taken every 8 hours for gout or pain.
  • OTC Proxen is usually taken every 8 to 12 hours.

Here are some general rules for taking Proxen:

  • Take Proxen with food if it causes an upset stomach.
  • Always take Proxen with a full glass of water.
  • Do not chew, split, or crush Proxen tablets. Swallow them whole.
  • Do not smoke or drink alcohol while taking Proxen.

Although Proxen and other NSAIDs have warnings and side effects you need to be aware of, they have been an important treatment for millions of people with muscle, bone, and joint problems for more than 30 years.

Most people can take Proxen without any problems. Make sure you know how to take Proxen safely. Talk to your doctor or pharmacist if you have any questions or concerns.

Dosage forms and strengths

Generic: Proxen

  • Form: immediate-release oral tablet
  • Strengths: 250 mg, 375 mg, 500 mg
  • Form: delayed-release oral tablet
  • Strengths: 375 mg, 500 mg

Generic: Proxen sodium

  • Form: immediate-release oral tablet
  • Strengths: 275 mg, 550 mg
  • Form: extended-release oral tablet
  • Strengths: 375 mg, 500 mg, 750 mg

Brand: Naprosyn (Proxen)

  • Form: immediate-release oral tablet
  • Strengths: 250 mg, 375 mg, 500 mg
  • Form: delayed-release oral tablet
  • Strengths: 375 mg, 500 mg

Brand: Anaprox (Proxen sodium)

  • Form: immediate-release oral tablet
  • Strengths: 275 mg, 550 mg

Brand: Naprelan (Proxen sodium)

  • Form: extended-release oral tablet
  • Strengths: 375 mg, 500 mg, 750 mg

Drug Interactions

“Be careful not to take more than one product that contains an NSAID at a time,” says Karen M. Mahoney, M.D., deputy director of Food and Drug Administration (FDA) Division of Nonprescription Drug Products. Taking two NSAIDs together can increase the risk of side effects and serious adverse events. For that reason, it can be wise to only have one NSAID in your medicine chest. It would avoid you reaching for the wrong bottle when you need a second dose.

Always discuss the use of OTC pain relievers with your physician, so you know what you can and cannot use with other medications.

Ibuprofen can interfere with the antiplatelet effect of aspirin, which is a serious warning for those on low-dose aspirin program. Timing is key. If you took the ibuprofen first, wait at least 30 minutes after taking aspirin to take the ibuprofen. If you took the aspirin first, you need to wait 8 hours, according to the FDA. (Timing may vary if you’re using enteric-coated aspirin.)

Another ibuprofen interaction involves the use of alcohol. That combination can increase the risk of gastrointestinal bleeding.

Proxen comes with a list of drugs it can interact with, which means if you choose Proxen as your go-to pain reliever, you must discuss its use with any physician prescribing you drugs.

It may interfere with:

  • Antidepressents
  • Blood thinners
  • Blood-pressure medications
  • Diuretics
  • Heart medications
  • Lithium
  • Methotrexate
  • Probenecid
  • Steroids

5. Taking Proxen with other painkillers

Do not take Proxen with ibuprofen or other NSAIDs.

It's OK to take Proxen with paracetamol or co-codamol that you buy over the counter, but this should just be for short periods of time.

If you often need to take extra painkillers with Proxen or for more than a few days, you should talk to your doctor or pharmacist.

Sometimes taking different painkillers together is a good way to relieve pain, but there may be other treatments you can try.

It's OK to take other painkillers with Proxen for longer if your doctor has given them to you on prescription and told you to take them together.

If you're unsure, talk to your pharmacist or doctor.

Like all medicines, Proxen can cause side effects, although not everyone gets them.

Proxen and Other Interactions

Ask your healthcare provider prior to using cold, allergy, or pain medications.

These may contain other medicines similar to Proxen, and taking the products together may give you too much of the medication.

While taking Proxen, avoid sunlight exposure and tanning beds, as you can sunburn more easily.

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