Progest is the main pro-gestational steroid hormone secreted by the female reproductive system. It is linked to the menstrual cycle, pregnancy, and development of an embryo. Progestin is an artificial form of Progest that is used for medical purposes.
The ovaries, placenta, and adrenal glands produce Progest to regulate the condition of the endometrium, which is the inner lining of the uterus.
Progest and Grapefruit Juice
The effect of grapefruit juice on Progest remains unclear.
To be safe, it might be best to avoid drinking grapefruit juice while taking Progest.
During the menstrual cycle
In the middle of a person’s menstrual cycle, a rise in levels of luteinizing hormone leads to ovulation. Ovulation refers to the release of an egg from one of the two ovaries. Once the egg is released, the corpus luteum forms and begins producing Progest.
Progest helps to prepare the body for pregnancy. For example, it causes lining of the uterus, called the endometrium, to thicken. This provides a good environment for implantation by a fertilized egg.
If the egg isn’t fertilized, the corpus luteum breaks down, leading to a drop in Progest levels. This decrease causes the thickened endometrium to break down, causing the beginning of a menstrual period.
What other information should I know?
Keep all appointments with your doctor.
Before having any laboratory test or biopsy (removal of tissue for testing), tell your doctor and the laboratory personnel that you are taking Progest.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
How to Increase Progest Naturally
Though no foods contain Progest, the following micro-nutrients can prov >support your body to boost Progest levels:
Good sources: Camu camu (Peruvian berry), sweet potato, kiwi, strawberries, oranges, papaya and pumpkin. Many other veggies also boost vitamin C too, including broccoli, mustard greens, tomatoes, Brussels sprouts and lemons.
Try this: Add ½ teaspoon of camu camu to any of these hormone balancing smoothie recipes.
This important mineral is not just a must-have for your immunity and skin. Zinc also helps the pituitary gland to release follicle-stimulating hormones. These encourage ovulation and they also tell your ovaries to produce more Progest, just in case you become pregnant each month.
Good sources: Oysters, shrimp (prawns), beef, lamb, liver, shellfish, red meat, pumpkin and cashew nuts.
This important mineral not only helps to preserve Progest levels through keeping you calmer, it also assists the breakdown of the antagonistic estrogen metabolites, reducing estrogen dominance.
Other good sources: Cashews, leafy greens such as kale and Swiss chard, pumpkin seeds, black beans, lentils and other legumes, cacao, mackerel fish and whole grain brown rice.
Research shows that vitamin E can help to improve luteal bloodflow and raise Progest levels in some women.
Sources: Sunflower seeds, almonds, and hazelnuts. In smaller amounts: avocado, sunflower seeds, red peppers, collard greens, pumpkin, asparagus, butternut squash, broccoli and mango.
The B vitamins help combat stress and also help your liver break down estrogen byproducts, reducing estrogen dominance.
Taking vitamin supplements of B6, can also help reduce levels of estrogen while boosting Progest production.
Good sources: Russet potatoes, salmon, tuna, bananas, spinach, walnuts, beef, chicken, sweet potato, beans and prunes.
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The Role of the Placenta in Progest Production
The placenta (the structure inside the uterus that provides oxygen and nutrients to a developing baby) will begin to produce Progest after 8 to 10 weeks of pregnancy to help maintain a healthy environment for the baby. At this point, the placenta increases Progest production to a higher rate than your ovaries were producing. These high levels of Progest throughout your pregnancy cause the body to stop producing more eggs, as well as prepare your breasts to produce milk. (3)
Progest is also produced in the adrenal glands of males. Its function is associated with sperm development.
There are a number of reasons that a healthcare provider may want to test Progest levels.
Some of them include:
- determining whether someone’s ovulated
- evaluating underlying causes of infertility
- determining whether someone’s had a miscarriage or ectopic pregnancy
- assessing people with a high-risk pregnancy or who are taking Progest during pregnancy
- narrowing down causes of abnormal uterine bleeding
- diagnosing an adrenal disorder
Progest levels are measured through a blood test. It’s important to remember that Progest levels fluctuate throughout the menstrual cycle, so levels can vary throughout the month.
Progest levels are measured in nanograms per milliliter (ng/mL). The chart below lists normal levels of Progest for an adult female during different points of the menstrual cycle and pregnancy.
How should I use Progest?
Use Progest exactly as it was prescribed for you. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Take the capsule with a full glass of water. It is best to take the medicine at night because this medicine can make you dizzy or drowsy.
Apply Progest cream to the skin as directed by your doctor.
Progest is sometimes used for only a short time, such as 10 to 12 days during each menstrual cycle. Follow your doctor's dosing instructions very carefully.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Progest.
If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using this medicine.
Store at room temperature away from moisture, heat, and light.
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- breast lumps
- migraine headache
- severe dizziness or faintness
- slow or difficult speech
- weakness or numbness of an arm or leg
- lack of coordination or loss of balance
- shortness of breath
- fast heartbeat
- sharp chest pain
- coughing up blood
- leg swelling or pain
- loss of vision or blurred vision
- bulging eyes
- double vision
- unexpected vaginal bleeding
- shaking hands that you cannot control
- stomach pain or swelling
- skin rash
- difficulty breathing or swallowing
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
Laboratory animals who were given Progest developed tumors. It is not known if Progest increases the risk of tumors in humans. Talk to your doctor about the risks of taking this medication.
Medications like Progest may cause abnormal blood clotting. This may cut off the blood supply to the brain, heart, lungs, or eyes and cause serious problems. Call your doctor if you experience any of the symptoms listed above as serious side effects. Talk to your doctor about the risks of taking this medication.
Progest may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Q: Can Progest cause weight gain?
A: Drugs can cause weight gain in several different ways. Some can increase appetite or make you crave certain types of foods like those high in carbohydrates or fat. Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. Also, the same medications can cause weight gain in certain individuals and weight loss in others. There are also drugs that initially cause weight loss and then lead to weight gain with long-term use. Most prescription medications associated with changes in body weight affect the central nervous system. These include antidepressants like monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and selective serotonin reuptake inhibitors (SSRIs). Mood stabilizers (lithium, valproic acid), antipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications (insulin, sulfonylureas, and thiazolidinediones), antihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors. Progest has been reported to possibly cause weight gain or weight loss. If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD
Commonly reported side effects of Progest include: abdominal cramps, depression, dizziness, and headache. Other side effects include: anxiety, cough, diarrhea, fatigue, musculoskeletal pain, nausea, bloating, emotional lability, and irritability. See below for a comprehensive list of adverse effects.
Pharmacologic class: Progestin
Therapeutic class: Hormone
Pregnancy risk category B (oral), D (injection),NR (vaginal)
Progest may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- breast tenderness or pain
- upset stomach
- muscle, joint, or bone pain
- mood swings
- excessive worrying
- runny nose
- vaginal discharge
- problems urinating
Why is this medication prescribed?
Progest is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy (surgery to remove the uterus). Hormone replacement therapy usually includes estrogen, which is used to treat symptoms of menopause and reduce the risk of developing certain diseases. However, estrogen can also cause abnormal thickening of the lining of the uterus and increase the risk of developing uterine cancer. Progest helps to prevent this thickening and decreases the risk of developing uterine cancer. Progest is also used to bring on menstruation (period) in women of childbearing age who have had normal periods and then stopped menstruating. Progest is in a class of medications called progestins (female hormones). It works as part of hormone replacement therapy by decreasing the amount of estrogen in the uterus. It works to bring on menstruation by replacing the natural Progest that some women are missing.
What Problems Can Occur with Progestin?
Women who have low levels of Progest will have abnormal menstrual cycles or may struggle to conceive because the Progest does not trigger the proper environment for a conceived egg to grow. Women who have low Progest levels and who do succeed in getting pregnant are at higher risk for miscarriage or pre-term delivery, because the hormone helps maintain the pregnancy.
If you are taking progestin to treat menopausal symptoms, for birth control, or to treat other conditions side effects may occur. Side effects may occur due to the dosage of progestin, how progestin interacts with hormone receptors, and your body’s response to progestin.
When taking progestin for menopausal symptoms, side effects may include mood changes, bloating, headaches, and breast tenderness. For newly menopausal women, breakthrough bleeding may occur.
In hormonal birth control, progestin side effects can include withdrawal bleeding and increased cramping. Other side effects may include an increased blood pressure and low blood sugar.
Progest is produced mainly in the corpus luteum and the ovaries but small amounts are also made in your adrenal glands. It is involved in the following important cascade, which is critical to female hormone balance:
How is Progest controlled?
The formation of the corpus luteum (which produces the majority of Progest) is triggered by a surge in luteinising hormone production by the anterior pituitary gland. This normally occurs at approximately day 14 of the menstrual cycle and it stimulates the release of an egg from the ovary and the formation of the corpus luteum. The corpus luteum then releases Progest, which prepares the body for pregnancy. If the egg is not fertilised and no embryo is conceived, the corpus luteum breaks down and the production of Progest decreases. As the lining of the womb is no longer maintained by Progest from the corpus luteum, it breaks away and menstrual bleeding occurs, marking the start of a new menstrual cycle.
However, if the ovulated egg is fertilised and gives rise to an embryo, the cells that surround this early embryo (which are destined to form the placenta) will secrete human chorionic gonadotrophin. This hormone has a very similar chemical structure to luteinising hormone. This means it can bind to and activate the same receptors as luteinising hormone, meaning that the corpus luteum does not break down and instead keeps producing Progest until the placenta is established.
home drugs a-z list Prometrium(Progest) side effects drug center
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Prometrium dose depends on the condition that is being treated. Drug interactions include inhibitors of cytochrome P450 3A4 (for example, ketoconazole), colchicine, dabigatran etexilate (Pradaxa), silodosin (Rapaflo) and aminoglutethimide (Cytadren). Do not use Prometrium without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Talk to your doctor about using birth control while you are using Prometrium. Prometrium passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.
Our Prometrium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.