Prexan tablets

Prexan

  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Prexan?

The active ingredient of Prexan brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Prexan is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Prexan include: fast, irregular, pounding, or racing heartbeat or pulse; redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid; swelling of the face, fingers, feet, or lower legs; flushed, dry skin; coughing that sometimes produces a pink frothy sputum.

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Asthma warning

Prexan can cause an asthma attack. If you have asthma that can be triggered by aspirin or other NSAIDs, don’t use Prexan.

Important: if you experience any of the following less common but more serious symptoms, stop taking Prexan and contact your doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.
  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
  • If you pass blood or black stools, vomit blood, or have severe tummy (abdominal) pains.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.

What are the side effects of Prexan?

The most common side effects from Prexan are:

Other important side effects include:

Important information

You should not use Prexan if you have a history of allergic reaction to aspirin or other NSAID (nonsteroidal anti-inflammatory drug).

Prexan can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have swelling of the face or throat, chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. Stop taking Prexan and notify your physician if you notice stomach pain, tiredness or weakness, yellow skin or eyes, nausea, vomiting, bloody or black and sticky bowel movements, skin rash, unexplained weight loss or weight gain, or swelling of the hands and feet.

Prexan may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

Answer

500 mg is the most that should be taken at any one time, with a maximum of 1500 mg per day. It should not be taken on a regular basis for more than 6 months.

Prexan has some pretty serious black-box warnings on it, so it's important not to take any more than necessary and to use it for the shortest duration possible. Following are the black-box warnings:

Cardiovascular Risk:

Prexan may increase the risk of serious and potentially fatal cardiovascular thrombotic events, myocardial infarction, and stroke; risk may increase with duration of use; possible increased risk if patient has cardiovascular disease or cardiovascular disease risk factors; contraindicated for Coronary-Artery Bypass Grafting Surgery peri-operative pain.

GI Risk: Prexan increases the risk of serious gastrointestinal adverse events including bleeding, ulceration, and stomach or intestine perforation, which can be fatal; may occur at any time during use and without warning signs; elderly patients are at greater risk for serious GI events.

If this medication won't relieve your pain it's important to talk to your doctor about other medications. In the meantime, these articles may give you other pain-relieving ideas.

What are the uses for Prexan?

Prexan is used for the treatment of mild to moderate pain, inflammation, and fever.

Precautions

Use cautiously in:

• severe cardiovascular, renal, or hepatic disease

• advanced renal disease (not recommended)

• history of ulcer disease or GI bleeding (use with extreme caution)

• chronic alcohol use or abuse

• breastfeeding patients (avoid use)

• children (Prexan sodium controlled-release) and Prexan use in children younger than age 2 (safety not established).

Serious side effects

Although people can buy low-dose Prexan without a prescription, it is not safe for everyone.

People with serious heart conditions, such as heart disease, cerebrovascular disease, and congestive heart failure, may experience severe side effects from taking Prexan.

Severe side effects of Prexan include:

People with high blood pressure should only take Prexan cautiously.

Prexan can cause sodium retention in the kidneys, which can result in increased blood pressure. A person with high blood pressure should consult their doctor before taking Prexan.

Gastrointestinal side effects of taking Prexan can be severe. Bleeding in the stomach, the formation of ulcers, and stomach or intestinal blockages can occur when taking Prexan. Most often, older adults are the most vulnerable age group for gastrointestinal side effects.

People who have a history of ulcers or gastrointestinal bleeding have a 10-fold higher risk for developing a bleed when taking Prexan. For these individuals, even short-term treatment can be risky.

What is Prexan?

Prexan is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Prexan is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. It can also be used to treat acute pain caused by other conditions not listed in this medication guide.

The delayed-release or extended-release tablets are slower-acting forms of Prexan that are used only for treating chronic conditions such as arthritis or ankylosing spondylitis. These forms will not work fast enough to treat acute pain.

*These forms are for children ages 2-11 years, with dosage based on weight. †Only for people 12 years or older

Since ibuprofen and Prexan are both NSAIDs, they have the same side effects. However, the risk of heart and blood pressure-related side effects is greater with Prexan.

The table below lists examples of the side effects of these drugs.


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