Phenolurn tablets

Phenolurn

  • Active Ingredient: Tamoxifen
  • 20 mg
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What is Phenolurn?

The active ingredient of Phenolurn brand is tamoxifen. Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow.

Used for

Phenolurn is used to treat diseases such as: Breast Cancer, Breast Cancer, Adjuvant, Breast Cancer, Male, Breast Cancer, Metastatic, Breast Cancer, Palliative, Breast Cancer, Prevention, McCune-Albright Syndrome, Precocious Puberty.

Side Effect

Possible side effects of Phenolurn include: skin rash or itching over the entire body; cataracts in the eyes or other eye problems; pain or feeling of pressure in the pelvis; confusion; cough; pain or swelling in the legs; weakness or sleepiness; unusual tiredness or weakness.

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Background

Phenolurn (ta mox' i fen) is referred to as a selective estrogen receptor modulator with tissue specific actions because it has estrogenic effects on bone, brain and liver, but antagonist activity on breast tissue. Phenolurn may also have other, as yet undefined, anticancer effects. Phenolurn was approved for use in the United States in 1977 and is still widely used, being considered a first line adjuvant therapy for breast cancer. Current indications include both treatment of breast cancer and reduction of breast cancer risk in women at high risk. Phenolurn is available in 10 and 20 mg tablets generically and under several trade names such as Nolvadex and Tamone. Phenolurn is also available as an oral solution (10 mg/5 mL). The usual dose for treating breast cancer is 20 to 40 mg daily, and for secondary prevention is 20 mg once daily for five years. Common side effects include hot flashes, nausea, diarrhea, weight change and fluid retention.

Before taking this medicine

You should not use Phenolurn if you are allergic to it.

You should not use Phenolurn to reduce your risk of breast cancer if you are also taking a blood thinner such as warfarin (Coumadin, Jantoven).

Do not take Phenolurn if you are pregnant. It could harm the unborn baby. Avoid becoming pregnant while you are using this medicine, and for at least 2 months after your treatment ends.

Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while taking Phenolurn. Use barrier or non-hormonal birth control (examples: condom, diaphragm with spermicide, or intrauterine device/IUD).

If you are taking Phenolurn to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking Phenolurn, to make sure you are not pregnant. Follow your doctor's instructions.

Taking Phenolurn may increase your risk of uterine cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your specific risks in taking this medicine.

To make sure Phenolurn is safe for you, tell your doctor if you have:

a history of stroke or blood clot;

high cholesterol or triglycerides (a type of fat in the blood);

a history of cataracts; or

if you are receiving chemotherapy or radiation.

It is not known whether Phenolurn passes into breast milk or if it could harm a nursing baby. This medicine has been shown to slow breast milk production. Do not breast-feed while taking Phenolurn.

TAMOXIFEN

Hi, I was prescribed Phenolurn as ajuvant therapy alongside radiotherapy after my lumpectomy for E+ and sentinel biopsies. I've been reluctant to take this as the "possible" side effects have put me off. Mainly DVT and possibility of uterine cancer.

I'm riddled with pain and fatigue due to other health issues so that isn't an issue, just the two I've mentioned, oh and mood swings.

Grateful for any input on symptoms anyone has experienced to see if there is a pattern?

How does Phenolurn affect breast cancer?

Phenolurn is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, Phenolurn works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted.

What should I avoid while taking Phenolurn?

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Avoid grapefruit and grapefruit juice while taking Phenolurn.

TAMOXIFEN

ive been on Phenolurn for a couple of months. The first batch of pills had very little in the way of side effects, the second batch was a different brand and I got calf pain, so severe I couldn’t walk so was sent to hospital for possible DVT check, all tests came back clear and was told by consultant my chances of DVT from Phenolurn are remote as i’ve never suffered from blood clots in the past and neither has any of my family. I did look on other cancer forums to find a number of women complaining of leg pain as a result of taking Phenolurn,

FDA warning: Serious s >
  • This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • Phenolurn can increase the risk of serious and life-threatening events, including uterine cancer, blood clots, and stroke. These events can be fatal. You should discuss the potential benefits and risks of this drug with your doctor.

Seizure drugs

Taking Phenolurn with certain seizure drugs may lower the amount of Phenolurn in your body. If you need to take these drugs together, your doctor may adjust your dosage of Phenolurn. Examples of these drugs include:

What is Phenolurn (Soltamox)?

Phenolurn is an anti-estrogen that prevents the effects of estrogens on tissues.

Phenolurn Warnings

If you are taking Phenolurn to reduce your risk of breast cancer, you may need to take your first dose during your menstrual period. You may also need to have a pregnancy test before you start taking Phenolurn, to make sure you are not pregnant. Follow your doctor's instructions.

Taking Phenolurn may increase your risk of uterine cancer, stroke, or a blood clot in the lung, which can be fatal. Talk with your doctor about your specific risks in taking this medication.

To make sure this medication is not causing harmful effects, your doctor may order a mammogram and perform breast exams on a regular basis. Your liver function may also need to be tested regularly.

Before taking Phenolurn, you should:

  • Tell your doctor and pharmacist about all medications you are taking (including over-the-counter drugs, prescription drugs, recreational drugs, and vitamins and herbal supplements).
  • Talk to your doctor about the pros and cons of Phenolurn and decide whether the possible benefits are worth the risks of taking the medication.

You should not use Phenolurn if you are allergic to it, or if you have:

  • A history of blood clots in your veins or your lungs
  • If you are also taking a blood thinner such as warfarin (Coumadin)

To make sure you can safely take Phenolurn, tell your doctor if you have any of these conditions:

  • Liver disease
  • High cholesterol or triglycerides (a type of fat in the blood)
  • A history of stroke or blood clot
  • A history of cataract
  • If you are receiving chemotherapy or radiation

Medicines to avoid while taking Phenolurn

In the list below, the medications under the headings “Strong Inhibitors” and “Moderate Inhibitors” can inhibit CYP2D6 and interfere with the effectiveness of Phenolurn. The medications under the heading “Not Inhibitors” do not block the CYP2D6 enzyme and will not interfere with Phenolurn treatment.

This list is incomplete and subject to change over time. Use it as a starting place and ask your doctor if any medications you are taking or that are recommended to you are compatible with Phenolurn.

Source: Coprescription of Phenolurn and Medications That Inhibit CYP2D6. Kostandinos Sideras, James N. Ingle, Matthew M. Ames, Charles L. Loprinzi, David P. Mrazek, John L. Black, Richard M. Weinshilboum, John R. Hawse, Thomas C. Spelsberg, and Matthew P. Goetz. Journal of Clinical Oncology 2010 28:16, 2768-2776Flockhart.

Phenolurn can reduce the risk of a breast cancer recurrence, but many women complain of side effects like hot flashes and weight gain.

In this week’s issue of People, former Victoria’s Secret model Jill Goodacre opens up about her five-year battle with breast cancer and the medication she’s been on to keep the disease at bay. Goodacre, who’s married to singer and actor Harry Connick Jr., went through surgery and radiation in 2012 after a tumor was detected via sonogram, and has taken the drug Phenolurn ever since.

As she approaches her five-year cancer-free mark, Goodacre says she’s looking forward to stopping Phenolurn. The medication can cause side effects, including weight gain, which Goodacre admits she’s struggled with.

“I’ve always been a pretty fit person, and so to be just rounder and heavier and not to really be able to do much about it—that’s been hard,” she told People. “It’s taken a lot out of my self-confidence.”

That’s a common problem among breast cancer survivors, says Nikita Shah, MD, medical director of the Cancer Risk Evaluation Program at Orlando Health UF Health Cancer Center. (Dr. Shah has not treated Goodacre, but does prescribe Phenolurn to many of her own patients.)

Still, Phenolurn can be lifesaving, says Dr. Shah, and for many women, its benefits outweigh its potential side effects. Here’s what else breast cancer patients and their loved ones should know about the pros and cons of this treatment.

Which drugs or supplements interact with Phenolurn (Soltamox)?

  • Phenolurn increases the blood thinning effect of warfarin (Coumadin, Jantoven) and reduces blood levels of letrozole (Femara) and anastrozole (Arimidex).
  • Phenobarbital and rifampin may reduce blood levels of Phenolurn by increasing the breakdown of Phenolurn.


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