Pabi-Naproxen tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Pabi-Naproxen?

The active ingredient of Pabi-Naproxen brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Pabi-Naproxen is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Pabi-Naproxen include: cough or hoarseness; lightheadedness; canker sores; change in the ability to see colors, especially blue or yellow; high fever; sore throat; difficult, burning, or painful urination; bloody or black, tarry stools.

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Important information

You should not use Pabi-Naproxen if you have a history of allergic reaction to aspirin or other NSAID (nonsteroidal anti-inflammatory drug).

Pabi-Naproxen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have swelling of the face or throat, chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. Stop taking Pabi-Naproxen and notify your physician if you notice stomach pain, tiredness or weakness, yellow skin or eyes, nausea, vomiting, bloody or black and sticky bowel movements, skin rash, unexplained weight loss or weight gain, or swelling of the hands and feet.

Pabi-Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using this medicine, especially in older adults.

Blood pressure drugs

Pabi-Naproxen might make your blood pressure medications not work as well. If you’re older than 65 years, combining Pabi-Naproxen with certain blood pressure medications may damage your kidneys. Examples of these medications include:

  • angiotensin-converting enzyme (ACE) inhibitors
  • angiotensin receptor blockers
  • beta-blockers, such as propranolol
  • diuretics

What Other Drugs Interact with Pabi-Naproxen?

If your doctor has directed you to use this NSAID, your medical doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first for more health information.

Pabi-Naproxen has no known severe interactions with any drugs.

Serious Interactions of Pabi-Naproxen include:

Pabi-Naproxen has moderate interactions with at least 229 different drugs.

Pabi-Naproxen has mild interactions with at least 80 different drugs.

This information does not contain all possible interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the medications you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions, concerns, or more health information.

What should I avoid while taking Pabi-Naproxen?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking Pabi-Naproxen.

Ask your doctor before taking any other medication for pain, arthritis, fever, or swelling. Many medicines available over the counter contain aspirin, salicylates, or other medicines similar to Pabi-Naproxen (such as ibuprofen or ketoprofen). Taking certain products together can cause you to get too much of this type of medication.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb Pabi-Naproxen.

Juvenile rheumatoid arthritis

Doctors can prescribe Pabi-Naproxen to manage the pain and inflammation caused by juvenile rheumatoid arthritis. People can administer the liquid suspension of Pabi-Naproxen to children 2 years old and older. The recommended dose is 10 mg per kilogram (kg), or mg/kg divided into two doses 12 hours apart.

5. Taking Pabi-Naproxen with other painkillers

Do not take Pabi-Naproxen with ibuprofen or other NSAIDs.

It's OK to take Pabi-Naproxen with paracetamol or co-codamol that you buy over the counter, but this should just be for short periods of time.

If you often need to take extra painkillers with Pabi-Naproxen or for more than a few days, you should talk to your doctor or pharmacist.

Sometimes taking different painkillers together is a good way to relieve pain, but there may be other treatments you can try.

It's OK to take other painkillers with Pabi-Naproxen for longer if your doctor has given them to you on prescription and told you to take them together.

If you're unsure, talk to your pharmacist or doctor.

Like all medicines, Pabi-Naproxen can cause side effects, although not everyone gets them.

Ibuprofen (Advil, Motrin) vs. Pabi-Naproxen (Aleve) comparison of differences

  • Ibuprofen (Advil, Motrin) and Pabi-Naproxen (Aleve) are both over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) used for the management of mild to moderate pain, fever, and inflammation.
  • Rash
  • Ringing in the ears (tinnitus)
  • Headaches
  • Dizziness
  • Drowsiness
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Constipation
  • Heartburn
  • Fluid retention (edema)
  • Blood clots
  • Heart attacks
  • High blood pressure (hypertension)
  • Heart failure
  • Both ibuprofen and Pabi-Naproxen both may interact with lithium, blood pressure medications, methotrexate (Trexall, Rheumatrex), aminoglycosides, anticoagulants, cyclosporine, furosemide, and thiazide diuretics.
  • Taking ibuprofen, Pabi-Naproxen, or other NSAIDs and consuming more than three alcoholic beverages per day may increase the risk of developing stomach ulcers.
  • Taking Pabi-Naproxen or ibuprofen with selective serotonin reuptake inhibitors (SSRIs) may increase the likelihood of gastrointestinal (GI) bleeding.
  • Brand names of Pabi-Naproxen include Anaprox, Naprelan, Naprosyn, and Aleve. Brand names of ibuprofen include Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, and PediaCare Fever.
  • More common side effects

    The more common side effects that occur with Pabi-Naproxen oral tablet include:

    • stomach pain
    • constipation
    • diarrhea
    • gas
    • heartburn
    • nausea and vomiting
    • dizziness

    Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

    Allergic reaction warning

    Pabi-Naproxen can cause a severe allergic reaction. Symptoms may include:

    • trouble breathing
    • swelling of your throat or tongue
    • hives

    If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

    Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

    Common side effects

    The following table from the Pabi-Naproxen monograph lists the most common side effects grouped by body system. The side effects in this table occur in approximately 3 to 9 percent of people.

    Q: I've been taking Pabi-Naproxen 500 mg twice a day for a year now for arthritis and bursitis pain. What are the long-term effects? Is it safe to continue?

    A: According to the medication guide for Pabi-Naproxen, you should not stop taking this medication with out first consulting your health care provider. Pabi-Naproxen is in a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases with longer use of NSAID medicines in people who have heart disease. NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and may cause death. NSAID medicines should only be used exactly as prescribed at the lowest dose possible for your treatment for the shortest time needed. Do not take an NSAID medicine if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine for pain right before or after heart bypass surgery. Tell your health care provider about all of your medical conditions and all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. These are not all the side effects with NSAID medicines. Talk to your health care provider for more information about NSAID medicines.

    Q: When my husband had outpatient surgery on his back (lumbar discectomy), we were told that he should not take Pabi-Naproxen (500 mg) because it hinders the healing process. Yet my foot doctor gave me a prescription for Pabi-Naproxen (500 mg) to ease the swelling I experienced after foot surgery. So we are confused. Does Pabi-Naproxen hinder the healing process? In both of our surgeries, we had bones that needed to heal.

    A: Non-steroidal anti-inflammatory drugs like Pabi-Naproxen are powerful and effective drugs. They are routinely used in orthopedic conditions and in the perioperative setting. They are however associated with potentially serious side effects, and it is important to evaluate the risk versus benefit prior to medication use. There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. Similarly, other data suggest that nonsteroidal anti-inflammatory drugs significantly inhibit spinal fusion at doses typically used for postoperative pain control.

    Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis

    People can manage the symptoms of osteoarthritis, which is commonly known as arthritis, rheumatoid arthritis, and ankylosing spondylitis with a dose of 220 mg to 550 mg of Pabi-Naproxen every 12 hours. Pabi-Naproxen does not cure these conditions but offers relief from pain and inflammation.

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