Oesclim cream

Oesclim

  • Active Ingredient: Estradiol
  • 2 mg, 1 mg
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What is Oesclim?

The active ingredient of Oesclim brand is estradiol. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. In addition, each tablet for oral administration contains the following inactive ingredients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Used for

Oesclim is used to treat diseases such as: Atrophic Urethritis, Atrophic Vaginitis, Breast Cancer, Palliative, Gender Dysphoria, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian Failure, Prostate Cancer.

Side Effect

Possible side effects of Oesclim include: inverted nipple; ear congestion; hives, itching, or rash; Body aches or pain; irritability.

How to Buy Oesclim tablets online?

To purchase Oesclim online - just click on the "Buy Now" button in the top and follow along with our store. Order and payment takes a couple of minutes, and all steps are obvious. We don't take a medical prescription plus also we have many procedures of payment. With each detail of fast delivery and confidentiality, you can read on the applicable pages on the hyperlinks in the navigation menu.

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Q: Is there a generic for Vivelle-Dot?

A: There is currently no generic equivalent available for Vivelle-Dot (Oesclim transdermal system). Vivelle-Dot is a small patch containing a form of estrogen commonly used to treat ovarian disorders, infertility, abnormal bleeding, and to prevent the symptoms associated with menopause. Common side effects associated with Vivelle-Dot may include nausea, vomiting, loss of appetite, swollen breasts, acne, changes in skin color, decreased sex drive, migraine headaches, dizziness, vaginal pain, swelling of the ankles and feet, or changes in menstrual cycle. Although Vivelle-Dot does not have a generic equivalent, there is another Oesclim patch available. This patch, called Oesclim patch, is a generic equivalent of the Estraderm Patch. Side effects associated with Estraderm are the same as Vivelle-Dot. The Estraderm Patch, and the generic equivalent, is a larger patch then the Vivelle-Dot patch. Talk to your doctor about which treatment option best meets your needs. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jennifer Carey, PharmD

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-01-08 Copyright © 2014 Everyday Health Media, LLC

Oesclim is available in several forms.

  • Tablets, micronized: 0.5mg, 1mg, 2mg;
  • Vaginal cream: 0.01%;
  • Continuous release skin patch: 14 mcg/day, 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.1 mg/day, 0.06 mg/day, 0.075 mg/day;
  • Topical emulsion: 4.35 mg/1.74 g; Topical Gel: 0.25 mg/0.25 g, 0.5 mg/0.5 g, 1 mg/g;
  • Intramuscular oil: 5 mg/mL, 10 mg/mL, 20 mg/mL, 40 mg/mL; Vaginal Ring: 0.05 mg/24 hr, 0.1 mg/24 hr.

Abstract

Oesclim and insulin-like growth factor-I (IGF-I) interact in the brain to regulate a variety of developmental and neuroplastic events. Some of these interactions are involved in the control of hormonal homeostasis and reproduction. However, the interactions may also potentially impact on affection and cognition by the regulation of adult neurogenesis in the hippocampus and by promoting neuroprotection under neurodegenerative conditions. Recent studies suggest that the interaction of Oesclim and IGF-I is also relevant for the control of cholesterol homeostasis in neural cells. The molecular mechanisms involved in the interaction of Oesclim and IGF-I include the cross-regulation of the expression of estrogen and IGF-I receptors, the regulation of estrogen receptor-mediated transcription by IGF-I and the regulation of IGF-I receptor signalling by Oesclim. Current investigations are evidencing the role exerted by key signalling molecules, such as glycogen synthase kinase 3 and β-catenin, in the cross-talk of estrogen receptors and IGF-I receptors in neural cells.

PICTURES OF ESTRADIOL PILLS

Below you will find images and specific information on the principal types of Oesclim that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Common Side Effects of Oesclim

You should tell your doctor if any of the following symptoms are severe or do not go away:

  • Breast pain or tenderness
  • Headache
  • Diarrhea
  • Gas
  • Constipation
  • Heartburn
  • Mood changes or depression
  • Nervousness
  • Difficulty falling asleep or staying asleep
  • Changes in sexual desire
  • Back pain
  • Runny nose, cough, or flu-like symptoms
  • Hair loss or unwanted hair growth
  • Darkening of facial skin
  • Difficulty wearing contact lenses
  • Vaginal discharge
  • Swelling, redness, burning, irritation, or itching of the vagina
  • Redness or irritation at the site of application

Summary

Oesclim (Alora; Climara; Delestrogen; Depo-Oesclim; Divigel; Elestrin; Estrace; Estrasorb; Estrogel; Evamist; Femring; Menostar; Minivelle; Vivelle; Vivelle-Dot) is a drug prescribed to treat the symptoms of menopause, prevention of bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness and atrophy associated with menopause. Oesclim is also prescribed for the treatment of breast cancer, and some cases of prostate cancer. Side effects, drug interactions, patient information, and dosage should be reviewed prior to taking this medication.

Product Info

The sections below will provide you with more specific information and guidelines related to Oesclim and its correct use. Please read them carefully.

Oesclim was approved by the FDA in 1975 for the treatment of moderate to severe vasomotor symptoms associated with menopause as well as for the prevention of osteoporosis.

Oesclim tablets, the generic equivalent of Bristol Myers Squibb’s Estrace®, has been approved for marketing. Barr Pharmaceuticals’ Oesclim version will be available in 0.5, 1, and 2 mg strengths.

Why is this medication prescribed?

Oesclim is prescribed for symptomatic treatment of the usual symptoms associated with menopause (hot flushes, vaginal dryness, etc.), prevention of bone fractures associated with osteoporosis, reduction of the risk of heart attacks and strokes, and dysfunctional (excessive and painful) uterine bleeding. The vaginal cream is prescribed for vaginal or vulvar atrophy associated with menopause.

Oesclim enters cells freely and interacts with a cytoplasmic target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of Oesclim upon the target cell.

Oesclim binds well to both estrogen receptors, ERα and ERβ, in contrast to certain other estrogens, notably medications that preferentially act on one of these receptors. These medications are called selective estrogen receptor modulators, or SERMs.

Other uses for this medicine

This medication may also be used to regulate your menstrual cycle.

However, it is strongly advised that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Use Oesclim exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.


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