Nopain gel


  • Active Ingredient: Diclofenac
  • 100 mg
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What is Nopain?

The active ingredient of Nopain brand is diclofenac. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. The inactive ingredients in Diclofenac sodium delayed-release tablets include: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium starch glycolate, talc, titanium dioxide, triethyl citrate.

Used for

Nopain is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Frozen Shoulder, Migraine, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica, Spondyloarthritis.

Side Effect

Possible side effects of Nopain include: belching; vomiting of blood or material that looks like coffee grounds; tightness in the chest; rapid weight gain; swelling; pale skin.

How to Buy Nopain tablets online?

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Rated Nopain for Osteoarthritis Report

It was an effective pain reliever for my hip, but a few days after taking 75 mg twice a day the muscles in my pelvis area developed pain and prevented me from standing and walking. My doctor advised me to stop this medication.

How to use Nopain Sodium

Read the Medication Guide provided by your pharmacist before you start using Nopain and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with a full glass of water (8 ounces / 240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. If you experience stomach upset with this medication, you may take it with food, milk, or an antacid. However, this may slow absorption and delay pain relief, especially if you are not taking this medication on a regular schedule.

Swallow this medication whole. Do not crush, chew, or break the tablets. Doing so can destroy the special coating on the tablet and may increase side effects.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.

For certain conditions (such as arthritis), it may take up to 2 weeks of regular use before the full benefits of this drug take effect.

If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition worsens.

Prescribed for Back Pain, Frozen Shoulder, Ankylosing Spondylitis, Aseptic Necrosis, Migraine, Spondyloarthritis, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica.

Nopain may also be used for purposes not listed in this medication guide.

Prescribed for Back Pain, Chronic Myofascial Pain, Costochondritis, Aseptic Necrosis, Headache, Muscle Pain, Fever, Patent Ductus Arteriosus, Gout - Acute, Radiculopathy, Polymyalgia Rheumatica, Sciatica, Rheumatoid Arthritis, Spondylolisthesis, Temporomandibular Joint Disorder, Toothache, Plantar Fasciitis, Neck Pain, Period Pain, Pain, Osteoarthritis, Juvenile Rheumatoid Arthritis, Frozen Shoulder, Eustachian Tube Dysfunction, Dysautonomia, Diffuse Idiopathic Skeletal Hyperostosis, Transverse Myelitis.

May also be prescribed off label for Herniated Disk.

What Other Drugs Interact with Nopain?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe interactions of Nopain include:

Serious Interactions of Nopain include:

Nopain has moderate interactions with at least 247 different drugs.

Nopain has mild interactions with at least 109 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Drugs that affect the flow of blood

Taking Nopain with other drugs that affect the flow of blood through your body can increase your risk of bleeding. Examples of these drugs include:

  • warfarin
  • aspirin
  • selective serotonin reuptake inhibitors (SSRIs), such as escitalopram, fluoxetine, paroxetine, and sertraline
  • serotonin norepinephrine reuptake inhibitors (SNRIs), such as desvenlafaxine, duloxetine, venlafaxine, and levomilnacipran

Nopain and Alcohol

You should not drink alcohol while taking Nopain. It can increase the risk of stomach bleeding and may cause damage to your kidneys.

  • Extended release: 100 mg orally once daily; may be increased to 100 mg orally every 12 hours

  • Nopain potassium: 50 mg orally every 8-12 hours
  • Nopain sodium: 50 mg orally every 8 hours or 75 mg orally every 12 hours
  • Extended release: 100 mg orally once daily; may be increased to 100 mg orally every 12 hours
  • Zorvolex: 35 mg orally three times/day

  • Safety and efficacy not established; drug has been used safely in limited number of children aged 3-16 years with juvenile rheumatoid arthritis
  • Children younger than 3 years: Safety and efficacy not established
  • Children 3 years and older: 2-3 mg/kg/day for up to 4 weeks

  • Nopain sodium: 25 mg orally 4 or 5 times daily
  • Nopain potassium: 50 mg orally every 12 hours

  • Immediate-release (Cataflam): 100 mg orally once, then 50 mg orally every 8 hours as needed

  • Immediate-release tab (Cataflam): 100 mg orally once, then 50 mg orally every 8 hours as needed
  • Zipsor: 25 mg orally four times/day as needed
  • Zorvolex: 18 mg or 35 mg orally three times/day

Pain (IV Administration)

  • Indicated for management of mild-to-moderate pain and moderate-to-severe pain alone or in combination with opioid analgesics
  • Use for the shortest duration consistent with individual patient treatment goals
  • 37.5 mg intravenous (IV) bolus injection infused over 15 seconds every 6 hours as needed, not to exceed 150 mg/day
  • To reduce the risk of renal adverse reactions, patients must be well hydrated prior to IV administration

  • Oral solution: 50 mg (1 packet) in 30-60 mL of water, mixed well and drunk immediately
  • Not for prophylaxis

  • Nopain potassium: Cambia, Cataflam, Zipsor
  • Nopain sodium: Voltaren XR

  • Take with food or 8-12 oz of water to avoid GI adverse effects
  • Zorvolex: Take on empty stomach; food decreases AUC by 11% and peak concentration by 60%
  • Oral solution: Do not use liquids other than water to reconstitute; foods decrease effectiveness
  • May be combined with misoprostol

Why is this medication prescribed?

Nopain capsules (Zipsor, Zorvolex) and tablets (Cataflam) are used to relieve mild to moderate pain. Nopain extended-release tablets (Voltaren XR), tablets (Cataflam), and delayed release tablets (available generically) are used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Nopain extended-release tablets and delayed-release tablets are also used to treat ankylosing spondylitis (arthritis that mainly affects the spine). Nopain tablets (Cataflam) are also used to treat painful menstrual periods. Nopain solution (Cambia) is used to treat migraine headaches in adults, but cannot be used to prevent migraines or to treat other types of headaches. Nopain is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.


GENERIC NAME(S): Nopain Sodium

Nonsteroidal anti-inflammatory drugs (including Nopain) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while using this drug but is more likely if you use it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not use this drug right before or after heart bypass surgery (CABG).

Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This side effect can occur without warning symptoms at any time while using Nopain. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)

Stop using Nopain and get medical help right away if you notice any of the following rare but very serious side effects: black/bloody stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden vision changes, slurred speech.

Talk with your doctor or pharmacist about the benefits and risks of using this medication.

See also Warning section.

This medication is used to relieve joint pain from arthritis. Nopain belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.

Important: if you experience any of the following less common but more serious symptoms, stop taking Nopain and contact your doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.
  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
  • If you pass blood or black stools, bring up (vomit) blood, or have severe tummy (abdominal) pains.

If you experience any other symptoms which you think may be due to Nopain, speak with your doctor or pharmacist for further advice.

Is Nopain safe to take if I'm pregnant or breastfeeding?

It is not known whether Nopain is excreted in breast milk.

9. Cautions with other medicines

There are some medicines that interfere with the way Nopain works. Tell your doctor if you're taking:

  • other anti-inflammatory medicines, such as aspirin or ibuprofen
  • antibiotics, such as ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin
  • blood thinners, such as warfarin
  • medicines for heart problems, such as digoxin, and medicines for high blood pressure
  • medicines to lower cholesterol, such as colestipol and cholestyramine
  • medicines to treat seizures, such as phenytoin
  • medicines that reduce the activity of your immune system, such as ciclosporin or tacrolimus
  • selective serotonin reuptake inhibitor (SSRI) antidepressants like citalopram or sertraline
  • steroid medicines, such as hydrocortisone or prednisolone
  • tablets that make you pee more, such as furosemide and bumetanide
  • lithium, which is used to treat mental health problems
  • methotrexate, which is used to treat some inflammatory diseases and cancers
  • mifepristone, which is used for ending a pregnancy (abortion)
  • zidovudine, which is used to treat HIV

What should I do if I forget a dose?

The powder for solution is usually taken as needed for migraine headaches. If you are taking any other Nopain product and you forget to take a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Rated Nopain for Osteoarthritis Report

I didn't find this drug to help me at all. I have torn tendons in my maxi and mid glut, arthritis in my hip and lower back pain. I think the doctor gave this drug to me so it wouldn't work and I would come back to him. Ultimately, he mentioned surgery on my back. I am seeing another doctor. Doctors see $$ signs inn this area. Not helping the patient to live a mobile life.

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