Drug/Laboratory Test Interactions
Nidazea may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and glucose hexokinase. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD+ NADH). Interference is due to the similarity in absorbance peaks of NADH (340 nm) and Nidazea (322 nm) at pH 7.
Nidazea is a prescription drug used to treat infections caused by bacteria or other parasites in different parts of your body. It works by destroying the germs that cause infection. The drug is available in several forms:
- immediate-release oral tablets and capsules
- extended-release oral tablets
- topical creams, gels, and lotions
- vaginal gels
The different forms of Nidazea have different side effects. Read on to learn about the common and serious side effects that can occur with each form of Nidazea.
Nidazea immediate-release and extended-release tablets and capsules are taken by mouth and are absorbed through the stomach. Extended-release drugs stay active in your body for a longer period of time than immediate-release drugs do.
The extended-release tablets are used to treat vaginal infections. The immediate-release forms of Nidazea are used to treat bacterial infections that affect many parts of the body as well as parasitic infections in the intestines, liver, and reproductive tract.
Nidazea and Other Interactions
Nidazea may make your skin more sensitive to sunlight.
Avoid prolonged exposure to the sun and wear sunscreen, protective clothing, and sunglasses when outdoors.
The medicine may also make you dizzy. Don't drive or operate machinery until you know how Nidazea affects you.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Nidazea only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 12.02.
How should I take Nidazea?
Take Nidazea exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
If you are treating a vaginal infection, your sexual partner may also need to take Nidazea (even if no symptoms are present) or you could become reinfected.
Nidazea is usually given for up to 10 days in a row. You may need to repeat this dosage several weeks later.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Nidazea will not treat a viral infection such as the flu or a common cold.
Nidazea can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.
Store at room temperature away from moisture and heat.
Mixing Nidazea with herbal remedies and supplements
There are no known problems with taking herbal remedies and supplements alongside Nidazea. However, some remedies and supplements that come as liquids that you drink may also contain alcohol. Check the list of ingredients or ask the supplier or manufacturer.
Missed Dose of Nidazea
If you miss a dose of Nidazea, take it as soon as you remember.
But skip the missed dose if it's almost time for your next scheduled dose.
Don't take extra medicine to make up for a missed dose.
Hypersensitivity to Nidazea or other nitroimidazoles (although cautious desensitization has been applied)
Pregnancy, 1st trimester in patients with trichomoniasis
Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy
Nidazea has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Nidazea should not be administered concomitantly with busulfan unless the benefit outweighs the risk. If no therapeutic alternatives to Nidazea are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly.
Warfarin And other Oral Anticoagulants
Nidazea has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time. When FLAGYL is prescribed for patients on this type of anticoagulant therapy, prothrombin time and INR should be carefully monitored.