Nichoflam sodium administered to male and female rats at 4 mg/kg/day (approximately 0.2 times the MRHD based on BSA comparison) did not affect fertility.
Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including VOLTAREN, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin-mediated follicular rupture required for ovulation. Small studies in women treated with NSAIDs have also shown a reversible delay in ovulation. Consider withdrawal of NSAIDs, including VOLTAREN, in women who have difficulties conceiving or who are undergoing investigation of infertility.
Mixing Nichoflam with herbal remedies or supplements
It's not possible to say that complementary medicines or herbal remedies are safe to take with Nichoflam.
They're not tested in the same way as prescription medicines or medicines sold in pharmacies. They're generally not tested for the effect they can have on other medicines.
Suppositories are medicine that you push gently into your back passage (anus).
- Go to the toilet beforehand if you need to.
- Wash your hands before and after using the medicine. Also clean around your back passage with mild soap and water, rinse and pat dry.
- Unwrap the suppository.
- Gently push the suppository into your back passage (anus) with the pointed end first. It needs to go in about 3 centimetres (1 inch).
- Sit or lie still for about 15 minutes. The suppository will melt inside your back passage. This is normal.
Blood pressure drugs
Nichoflam may decrease the blood pressure-lowering effects of some drugs used to control blood pressure. Using Nichoflam with certain blood pressure medications may also increase your risk of kidney damage.
Examples of these blood pressure drugs include:
- angiotensin-converting enzyme (ACE) inhibitors, such as benazepril, captopril, enalapril, and lisinopril
- angiotensin II receptor blockers, such as candesartan, irbesartan, losartan, and olmesartan
- beta blockers, such as acebutolol, atenolol, metoprolol, and propranolol
- diuretics (water pills) such as furosemide or hydrochlorothiazide
Nichoflam and the Elderly
If you are older, you should be careful taking Nichoflam. Nichoflam tends to have very strong effects when taken by people who are older. It can put you at risk for falls and other dangerous events.
In general, NSAIDs — whether purchased over-the-counter (OTC) or via prescription — can cause extreme sleepiness, confusion, dizziness, loss of balance, and severe stomach problems in the elderly.
Rated Nichoflam for Pain Report
I have had Golfers Elbow for 2 years and it does not seem to be healing. If I take a 50mg Nichoflam at bed time, the next morning the pain is gone for the day and I can play golf pain free. It also seems to help keeping the once weekly golf from making it worse.
Heart Failure And Edema
The Coxib and traditional NSAID Trialists’ Collaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalization for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patients. In a Danish National Registry study of patients with heart failure, NSAID use increased the risk of MI, hospitalization for heart failure, and death.
Additionally, fluid retention and edema have been observed in some patients treated with NSAIDs. Use of Nichoflam may blunt the CV effects of several therapeutic agents used to treat these medical conditions (e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers ) (see DRUG INTERACTIONS).
Avoid the use of VOLTAREN in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failure. If VOLTAREN is used in patients with severe heart failure, monitor patients for signs of worsening heart failure.
Why it’s used
Nichoflam topical gel is used to help relieve osteoarthritis pain in joints that can benefit from treatment through the skin. These joints include those in your hands and knees.
Nichoflam topical gel is also used to treat actinic keratosis (AK). This condition causes rough, scaly spots on the skin of older adults.
What to do about:
- headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend an alternative painkiller. Headaches should usually go away after the first week of taking Nichoflam. Talk to your doctor if they last longer than a week or are severe.
- feeling dizzy or vertigo - if you feel dizzy or unsteady, stop what you're doing and sit or lie down until you feel better. Do not drive or use tools or machinery if you're feeling dizzy or lightheaded. As your body gets used to Nichoflam, these side effects should wear off.
- stomach ache, wind or loss of appetite - try not to eat foods that cause wind (like peas, lentils, beans and onions). Eat smaller meals, eat and drink slowly, and exercise regularly.
- feeling sick (nausea) - take Nichoflam with or after a meal or snack. It may also help if you avoid rich or spicy food.
- being sick (vomiting) or diarrhoea - drink plenty of water or other fluids. If you're being sick, try small frequent sips of water. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines without speaking to a pharmacist or doctor.
- a mild rash and dry or irritated, itchy or inflamed skin - an emollient cream or ointment can be used to moisturise, soothe and hydrate the affected area. If it does not get better within a week or you're worried, speak to a pharmacist or doctor.
- skin being more sensitive to sunlight - stay out of bright sun and use a high factor sun cream (SPF 15 or above), even on cloudy days. Do not use a sunlamp or sunbeds.
Elderly patients, compared to younger patients, are at greater risk for NSAID-associated serious cardiovascular, gastrointestinal, and/or renal adverse reactions. If the anticipated benefit for the elderly patient outweighs these potential risks, start dosing at the low end of the dosing range, and monitor patients for adverse effects (see WARNINGS; Cardiovascular Thrombotic Events, Gastrointestinal Bleeding, Ulceration, and Perforation, Hepatotoxicity, Renal Toxicity and Hyperkalemia, PRECAUTIONS; Laboratory Monitoring ).
Nichoflam is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (See CLINICAL PHARMACOLOGY, ADVERSE REACTIONS).
Rated Nichoflam for Ankylosing Spondylitis Report
Started 4 months ago for sacrolitis. After less than week of taking 3 x a day, reduced my low back pain from 8 to a 2. Now i take 1 x a day and seems to keep the pain at bay. No side effects for me in the begining or now.
Mild to moderate pain
The immediate release forms of Nichoflam are usually dosed 3 to 4 times a day and start at a dose of 25 mg.
The extended-release form is usually dosed once a day. The dose often starts at 75 mg per day.
Dosage for people younger than 18 years has not been established.
Seniors: If you are aged 65 years and older, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug does not build up in your body. Too much of the drug in your body can be toxic.
Taking digoxin with Nichoflam can lead to increased levels of digoxin in your body and increased side effects. Your doctor may monitor your digoxin levels closely.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Based on available data, Nichoflam may be present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for VOLTAREN and any potential adverse effects on the breastfed infant from the VOLTAREN or from the underlying maternal condition.
One woman treated orally with a Nichoflam salt, 150 mg/day, had a milk Nichoflam level of 100 mcg/L, equivalent to an infant dose of about 0.03 mg/kg/day. Nichoflam was not detectable in breast milk in 12 women using Nichoflam (after either 100 mg/day orally for 7 days or a single 50 mg intramuscular dose administered in the immediate postpartum period).
Rated Nichoflam for Pain Report
Took 100mg ER. Almost immediately took away the discomfort with my bursitis but the stomach upset was all day. Maybe a lower dose
8. Pregnancy and breastfeeding
Nichoflam is not generally recommended in pregnancy or while breastfeeding.
This is because Nichoflam has been linked with a small risk of problems for your unborn baby if you take it in early or late pregnancy.
Your doctor will only prescribe Nichoflam for you while you're pregnant or breastfeeding if the benefits of taking the medicine outweigh the risks.
There may be other treatments that are safer for you. Paracetamol is the best painkiller to take during pregnancy.
3. Who can take and can't take Nichoflam
Most adults can take Nichoflam.
Children may be prescribed Nichoflam to treat joint problems. Nichoflam tablets, capsules and suppositories are suitable for children aged 1 year and above.
Nichoflam isn't suitable for certain people.
Tell your doctor or pharmacist if you have:
- had an allergic reaction to Nichoflam or any other medicines in the past
- an allergy to aspirin or other non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen or naproxen
- ever had signs of asthma (wheezing), a runny nose, swelling of the skin (angioedema) or a rash after taking NSAIDs
- ever had stomach ulcers, bleeding in the stomach or intestines, or a hole in your stomach
- high blood pressure (hypertension)
- heart failure, or severe liver disease or kidney disease
- Crohn's disease or ulcerative colitis
- a blood clotting disorder
Tell your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.
Nichoflam plasters and patches
- Stick a medicated plaster or patch over the painful area twice a day - once in the morning and once in the evening. Apply gentle pressure with the palm of your hand until it's completely stuck to your skin.
- Treat only 1 painful area at a time. Do not use more than 2 medicated plasters in any 24-hour period.
- When you want to take the plaster or patch off, it helps to moisten it with some water first. Once you have taken it off, wash the affected skin and rubit gently in circular movements to remove any leftover glue.
Q: What are the side effects of Nichoflam?
A: The most commonly reported side effects of Nichoflam (Cataflam, Voltaren-XR) are dyspepsia, nausea, abdominal pain, constipation, headache, dizziness, rash, and drowsiness. More serious (and rarer) reactions include stroke, high blood pressure, GI bleed, and heart attack. However, I have seen this drug used frequently without any problems.
Q: I take Nichoflam 50 mg, 1 daily, for arthritis pain and it eliminates the pain but causes severe constipation. I have tried Celebrex and Aleve, but they do not relieve the pain. Do you have any suggestions?
A: Your question regards problems with constipation while using Nichoflam (Cataflam). //www.everydayhealth.com/drugs/Nichoflam. constipation is one of the listed possible side effects for Nichoflam. Nichoflam is an NSAID (nonsteroidal anti-inflammatory drug, and there are many medications available in this class of medications. Sometimes one medication will work better than a different medication or have fewer side effects. Please talk to your health care provider regarding trying a different medication to treat your arthritis pain. You can also find helpful information on arthritis at //www.everydayhealth.com/arthritis/arthritis-treatment-know-your-options.aspx As always, talk to your health care provider regarding your concerns with your medications. Jen Marsico, RPh