Important: if you experience any of the following less common but more serious symptoms, stop taking Naprometin and contact your doctor for advice straightaway:
- If you have any breathing difficulties such as wheeze or breathlessness.
- If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
- If you pass blood or black stools, vomit blood, or have severe tummy (abdominal) pains.
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.
Naprometin (Aleve, Anaprox, Naprelan, Naprosyn) is in the class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naprometin is prescribed for the treatment of mild to moderate pain, inflammation, and fever. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
Q: When my husband had outpatient surgery on his back (lumbar discectomy), we were told that he should not take Naprometin (500 mg) because it hinders the healing process. Yet my foot doctor gave me a prescription for Naprometin (500 mg) to ease the swelling I experienced after foot surgery. So we are confused. Does Naprometin hinder the healing process? In both of our surgeries, we had bones that needed to heal.
A: Non-steroidal anti-inflammatory drugs like Naprometin are powerful and effective drugs. They are routinely used in orthopedic conditions and in the perioperative setting. They are however associated with potentially serious side effects, and it is important to evaluate the risk versus benefit prior to medication use. There is evidence suggesting that these drugs adversely affect bone formation, and this has implications for their use in patients with fractures and other pathologies that involve bone remodelling. Similarly, other data suggest that nonsteroidal anti-inflammatory drugs significantly inhibit spinal fusion at doses typically used for postoperative pain control.
How should this medicine be used?
Prescription Naprometin comes as a regular tablet, a delayed-release (a tablet that releases the medication in the intestine to prevent damage to the stomach) tablet, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. The extended-release tablets are usually taken once a day. The tablets, delayed-release tablets, and suspension are usually taken twice a day for arthritis. The tablets and suspension are usually taken every 8 hours for gout, and every 6 to 8 hours as needed for pain. If you are taking Naprometin on a regular basis, you should take it at the same time(s) every day.
Nonprescription Naprometin comes as tablet and a gelatin coated tablet to take by mouth. It is usually taken with a full glass of water every 8 to 12 hours as needed. Nonprescription Naprometin may be taken with food or milk to prevent nausea.
Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Naprometin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or written on the package.
Shake the liquid well before each use to mix the medication evenly. Use the measuring cup provided to measure each dose of the liquid.
Swallow the delayed-release tablets and extended release tablets whole; do not split, chew, or crush them.
If you are taking Naprometin to relieve the symptoms of arthritis, your symptoms may begin to improve within 1 week. It may take 2 weeks or longer for you to feel the full benefit of the medication.
Stop taking nonprescription Naprometin and call your doctor if your symptoms get worse, you develop new or unexpected symptoms, the part of your body that was painful becomes red or swollen, your pain lasts for more than 10 days, or your fever lasts for more than 3 days.
Bernard-Soulier Disease (Giant Platelet Syndrome)
Bernard-Soulier disease is a rare inherited bleeding disorder caused by a defect in the platelet glycoprotein complex 1b-IX-V. Symptoms and signs include: bruising, nosebleeds, gum bleeding, and problems with anything that induces bleeding, such as surgery, ulcers, trauma, and menstruation. Treatment involves avoiding medications that interfere with clot formation, such as Naprometin, ibuprofen, and aspirin. People with Bernard-Soulier syndrome should avoid contact sports.
Indications and dosages
➣ Pain; osteoarthritis; ankylosing spondylitis; dysmenorrhea; bursitis; acute tendinitis
Adults: 250 to 500 mg (Naprometin) P.O. b.i.d. (up to 1.5 g/day); 375 to 500 mg (Naprometin delayed-release) P.O. t.i.d.; 250 mg, 375 mg, or 500 mg (Naprometin oral suspension) P.O. b.i.d.; 275 to 550 mg (Naprometin sodium) P.O. b.i.d. (up to 1.65 g/day)
Children: 10 mg/kg P.O. daily in two divided doses (Naprometin only)
➣ Mild to moderate pain; primary dysmenorrhea
Adults: Initially, 500 mg (Naprometin) P.O., followed by 250 mg q 6 to 8 hours p.r.n., to a maximum of 1.25 g/day. Or initially, 550 mg (Naprometin sodium) P.O., followed by 275 mg q 6 to 8 hours p.r.n., to a maximum of 1,375 mg/day.
Adults: Initially, 750 mg (Naprometin) P.O., followed by 250 mg q 8 hours or initially, 825 mg (Naprometin sodium) P.O., followed by 275 mg q 8 hours. On day 1,1,000 to 1,500 mg (Naprometin sodium controlled-release formulation) P.O. once daily, followed by 1,000 mg once daily until attack has subsided.
➣ Management of pain, primary dysmenorrhea, acute tendinitis and bursitis
Adults: Initially, two 500-mg Naprometin sodium controlled-release tablets P.O. once daily. Or, for patients requiring greater analgesic benefit, two 750-mg Naprometin sodium controlled-release tablets P.O. once daily. Or, three 500-mg Naprometin sodium controlled-release tablets may be used for a limited period. Thereafter, total daily dose shouldn't exceed two 500-mg tablets.
➣ Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis
Adults: Initially, two 375-mg Naprometin sodium controlled-release tablets P.O. once daily, one 750-mg tablet P.O. once daily, or two 500-mg tablets P.O. once daily. During long-term administration, adjust dosage up or down depending on patient's clinical response. Use lowest effective dose in all patients. (Patients already taking Naprometin 250 mg, 375 mg, or 500 mg b.i.d. may have their total daily dosage replaced with Naprometin sodium controlled-release tablets as a single daily dose.)