Drug-drug. Acetaminophen (chronic use), cyclosporine: increased risk of adverse renal effects
Anticoagulants, thrombolytics: increased anticoagulant effect
Antihypertensives, cefamandole, cefoperazone, cefotetan, diuretics, eptifibatide: decreased response
Antineoplastics, methotrexate: increased risk of nephrotoxicity
Aspirin: decreased Naprobene efficacy
Aspirin, corticosteroids, other NSAIDs: additive adverse GI effects
Clopidogrel, plicamycin, ticlopidine, valproic acid: increased risk of bleeding Insulin, oral hypoglycemics: increased risk of hypoglycemia
Lithium: increased lithium blood level and risk of nephrotoxicity
Other photosensitizing agents: increased risk of photosensitivity
Probenecid: increased Naprobene blood level, increased risk of toxicity
Drug-diagnostic tests. Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, creatinine, lactate dehydroge-nase, potassium: increased levels
Bleeding time: prolonged for up to 4 days after therapy ends
Creatinine clearance, glucose, hematocrit, hemoglobin, leukocytes, platelets: decreased values
Urine 5-hydroxy-indoleacetic acid, urine steroids: test interference
Drug-herbs. Anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased anticoagulant effect, increased risk of bleeding
What other drugs will affect Naprobene?
Ask your doctor before using Naprobene if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.
Ask a doctor or pharmacist if it is safe for you to use this medicine if you are also using any of the following drugs:
phenytoin or similar seizure medications;
warfarin (Coumadin, Jantoven) or similar blood thinners;
a diuretic or "water pill";
heart or blood pressure medication; or
insulin or oral diabetes medicine.
This list is not complete. Other drugs may interact with Naprobene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
If you take Naprobene with lithium, it may increase the lithium in your body to harmful levels.
Q: I used to take Darvocet because I have sciatica pain and the doctor took me off of it and put me on Naprobene 500 mg twice daily. Now I am having shortness of breath and so tired I can hardly walk. I have been on this for one month. Could this medicine be causing me shortness of breath and the feeling of passing out?
A: Naprobene is a non-steroidal anti-inflammatory drug (or NSAID) that is used to treat pain and inflammation. The most common side effects of Naprobene are heartburn, abdominal pain, nausea, constipation, headache, dizziness, drowsiness, itching, skin rashes, ringing of the ears, swelling, and shortness of breath. Naprobene, like other NSAIDs, may cause serious cardiovascular side effects, such as heart attack or stroke. Although serious cardiovascular events can occur without warning symptoms, patients should be aware of the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should contact their health care provider if any of these occur. Michelle McDermott, PharmD
- Store Naprobene at room temperature between 68°F and 77°F (20°C and 25°C).
- Keep the container tightly closed and protect the drug from light.
COMMON BRAND(S): Aleve, Anaprox, Naprosyn
GENERIC NAME(S): Naprobene
Nonsteroidal anti-inflammatory drugs (including Naprobene) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).
This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.
Stop taking Naprobene and get medical help right away if you notice any of these rare but serious side effects: stomach/abdominal pain that doesn't go away, black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, trouble speaking, sudden vision changes.
Talk to your doctor or pharmacist about the benefits and risks of taking this drug.
See also Warning section.
Naprobene is used to relieve pain from various conditions such as headache, muscle aches, tendonitis, dental pain, and menstrual cramps. It also reduces pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.
Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.
What Other Drugs Interact with Naprobene?
If your doctor has directed you to use this NSAID, your medical doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first for more health information.
Naprobene has no known severe interactions with any drugs.
Serious Interactions of Naprobene include:
Naprobene has moderate interactions with at least 229 different drugs.
Naprobene has mild interactions with at least 80 different drugs.
This information does not contain all possible interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the medications you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions, concerns, or more health information.
More common side effects
The more common side effects that occur with Naprobene oral tablet include:
- stomach pain
- nausea and vomiting
Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.
Efectos secundarios del Naprobeneo
Como los demás medicamentos, el Naprobeneo tiene reacciones secundarias, que si son prolongadas deben de ser tratadas o cancelado el tratamiento. Algunos de los efectos secundarios son:
Allergic reaction warning
Naprobene can cause a severe allergic reaction. Symptoms may include:
- trouble breathing
- swelling of your throat or tongue
If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis
People can manage the symptoms of osteoarthritis, which is commonly known as arthritis, rheumatoid arthritis, and ankylosing spondylitis with a dose of 220 mg to 550 mg of Naprobene every 12 hours. Naprobene does not cure these conditions but offers relief from pain and inflammation.