Naprobene tablets

Naprobene

  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Naprobene?

The active ingredient of Naprobene brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Naprobene is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Naprobene include: loss of appetite; increased sweating; fainting; severe stomach burning, cramping, or pain; swelling or inflammation of the mouth; redness or other discoloration of the skin.

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Interactions

Drug-drug. Acetaminophen (chronic use), cyclosporine: increased risk of adverse renal effects

Anticoagulants, thrombolytics: increased anticoagulant effect

Antihypertensives, cefamandole, cefoperazone, cefotetan, diuretics, eptifibatide: decreased response

Antineoplastics, methotrexate: increased risk of nephrotoxicity

Aspirin: decreased Naprobene efficacy

Aspirin, corticosteroids, other NSAIDs: additive adverse GI effects

Clopidogrel, plicamycin, ticlopidine, valproic acid: increased risk of bleeding Insulin, oral hypoglycemics: increased risk of hypoglycemia

Lithium: increased lithium blood level and risk of nephrotoxicity

Other photosensitizing agents: increased risk of photosensitivity

Probenecid: increased Naprobene blood level, increased risk of toxicity

Drug-diagnostic tests. Alanine amino-transferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, creatinine, lactate dehydroge-nase, potassium: increased levels

Bleeding time: prolonged for up to 4 days after therapy ends

Creatinine clearance, glucose, hematocrit, hemoglobin, leukocytes, platelets: decreased values

Urine 5-hydroxy-indoleacetic acid, urine steroids: test interference

Drug-herbs. Anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased anticoagulant effect, increased risk of bleeding

What other drugs will affect Naprobene?

Ask your doctor before using Naprobene if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you are also using any of the following drugs:

phenytoin or similar seizure medications;

warfarin (Coumadin, Jantoven) or similar blood thinners;

a diuretic or "water pill";

heart or blood pressure medication; or

insulin or oral diabetes medicine.

This list is not complete. Other drugs may interact with Naprobene, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Lithium

If you take Naprobene with lithium, it may increase the lithium in your body to harmful levels.

Q: I used to take Darvocet because I have sciatica pain and the doctor took me off of it and put me on Naprobene 500 mg twice daily. Now I am having shortness of breath and so tired I can hardly walk. I have been on this for one month. Could this medicine be causing me shortness of breath and the feeling of passing out?

A: Naprobene is a non-steroidal anti-inflammatory drug (or NSAID) that is used to treat pain and inflammation. The most common side effects of Naprobene are heartburn, abdominal pain, nausea, constipation, headache, dizziness, drowsiness, itching, skin rashes, ringing of the ears, swelling, and shortness of breath. Naprobene, like other NSAIDs, may cause serious cardiovascular side effects, such as heart attack or stroke. Although serious cardiovascular events can occur without warning symptoms, patients should be aware of the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should contact their health care provider if any of these occur. Michelle McDermott, PharmD

Storage

  • Store Naprobene at room temperature between 68°F and 77°F (20°C and 25°C).
  • Keep the container tightly closed and protect the drug from light.

COMMON BRAND(S): Aleve, Anaprox, Naprosyn

GENERIC NAME(S): Naprobene

Nonsteroidal anti-inflammatory drugs (including Naprobene) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).

This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.

Stop taking Naprobene and get medical help right away if you notice any of these rare but serious side effects: stomach/abdominal pain that doesn't go away, black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, trouble speaking, sudden vision changes.

Talk to your doctor or pharmacist about the benefits and risks of taking this drug.

See also Warning section.

Naprobene is used to relieve pain from various conditions such as headache, muscle aches, tendonitis, dental pain, and menstrual cramps. It also reduces pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.

Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

What Other Drugs Interact with Naprobene?

If your doctor has directed you to use this NSAID, your medical doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first for more health information.

Naprobene has no known severe interactions with any drugs.

Serious Interactions of Naprobene include:

Naprobene has moderate interactions with at least 229 different drugs.

Naprobene has mild interactions with at least 80 different drugs.

This information does not contain all possible interactions. Therefore, before using this drug, tell your doctor or pharmacist of all the medications you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions, concerns, or more health information.

More common side effects

The more common side effects that occur with Naprobene oral tablet include:

  • stomach pain
  • constipation
  • diarrhea
  • gas
  • heartburn
  • nausea and vomiting
  • dizziness

Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.

Efectos secundarios del Naprobeneo

Como los demás medicamentos, el Naprobeneo tiene reacciones secundarias, que si son prolongadas deben de ser tratadas o cancelado el tratamiento. Algunos de los efectos secundarios son:

  • Cefalea
  • Diarrea
  • Vomito
  • Mareos
  • Somnolencia
  • Hormigueo
  • Estreñimiento
  • Insomnio

Allergic reaction warning

Naprobene can cause a severe allergic reaction. Symptoms may include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis

People can manage the symptoms of osteoarthritis, which is commonly known as arthritis, rheumatoid arthritis, and ankylosing spondylitis with a dose of 220 mg to 550 mg of Naprobene every 12 hours. Naprobene does not cure these conditions but offers relief from pain and inflammation.


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