Metronide lotion

Metronide

  • Active Ingredient: Metronidazole
  • 500 mg, 400 mg, 250 mg, 200 mg
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What is Metronide?

The active ingredient of Metronide brand is metronidazole. Metronidazole is an antibiotic that fights bacteria.

Used for

Metronide is used to treat diseases such as: Amebiasis, Aspiration Pneumonia, Bacteremia, Bacterial Infection, Bacterial Vaginitis, Balantidium coli, Bone infection, Clostridial Infection, Crohn's Disease, Acute, Crohn's Disease, Maintenance, Deep Neck Infection, Dental Abscess, Dientamoeba fragilis, Diverticulitis, Dracunculiasis, Endocarditis, Giardiasis, Helicobacter Pylori Infection, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Meningitis, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Pouchitis, Pseudomembranous Colitis, Skin or Soft Tissue Infection, STD Prophylaxis, Surgical Prophylaxis, Trichomoniasis.

Side Effect

Possible side effects of Metronide include: frequent or painful urination; confusion; constipation; chest pain; unusual bleeding or bruising; bloating; eye pain.

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Contraindications

  • Hypersensitivity to Metronide or other nitroimidazoles (although cautious desensitization has been applied)
  • Pregnancy, 1st trimester (controversial)
  • Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy

Effects of Drug Abuse

  • No information available

  • See "What Are Side Effects Associated with Using Metronide?"

  • Encephalopathcy, seizures, aseptic meningitis, and neuropathies reported with increase in dose and chronic therapy
  • Superinfection may occur with prolonged use
  • See "What Are Side Effects Associated with Using Metronide?"

  • Encephalopathy, seizures, aseptic meningitis, and neuropathies reported with increase in dose and chronic therapy
  • Superinfection may occur with prolonged use
  • Severe hepatic impairment; administer lower doses with caution
  • Use with caution; potential accumulation in end stagerenal disease; supplemental doses may be needed in patients receiving hemodialysis
  • Use with caution in history of blood dyscrasias, heart failure, hepatic failure, H. pylori infection, renal impairment
  • Avoid alcohol while taking medication and for at least 1 day after discontinuation
  • Antiandrogen: May cause gynecomastia
  • Known or previously unrecognized candidiasis may present more prominent symptoms during therapy with Metronide Injection and requires treatment with a candicidal agent

  • Metronide may be acceptable for use during pregnancy. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. There are published data from case-control studies, cohort studies, and 2 meta-analyses that included more than 5000 pregnant women who used Metronide systemically during pregnancy
  • Many studies included first trimester exposures. One study showed an increased risk of cleft lip, with or without cleft palate, in infants exposed to Metronide in utero; however, these findings were not confirmed
  • In addition, more than 10 randomized, placebo-controlledclinical trials that together enrolled over 5000 pregnant women assessed the possible effect of systemic antibiotic treatment (including with Metronide) for bacterial vaginosis on the incidence of preterm delivery; most studies did not show an increased risk of congenital anomalies or other adverse fetal outcomes following Metronide exposure during pregnancy
  • Three studies conducted to assess the risk of infantcancer following systemic Metronide exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited.
  • Metronide is excreted in human milk; it is not recommended for use while breastfeeding
  • Following oral administration, concentrations in human milk are similar to concentrations in plasma
  • Potential for tumorigenicity shown in animal studies; a decision should be made whether to discontinue nursing or to discontinue Metronide; breastfeeding women may choose to pump and discard milk for the duration of therapy and for 24 hours after therapy ends and to feed her infant stored human milk or formula

DESCRIPTION

FLAGYL (Metronide) tablets, 250 mg or 500 mg is an oral formulation of the synthetic nitroimidazole antimicrobial, 2-methyl-5-nitro-1H-imidazole-1-ethanol, which has the following structural formula:

FLAGYL (Metronide) tablets contain 250 mg or 500 mg of Metronide. Inactive ingredients include cellulose, FD&C Blue No. 2 Lake, hydroxypropyl cellulose, hypromellose, polyethylene glycol, stearic acid, and titanium dioxide.

Lactation

Metronide is present in human milk at concentrations similar to maternal serum levels, and infant serum levels can be close to or comparable to infant therapeutic levels

Because of potential for tumorigenicity shown for Metronide in mouse and rat studies, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother; alternatively, a nursing mother may choose to pump and discard human milk for duration of Metronide therapy, and for 24 hours after therapy ends and feed her infant stored human milk or formula

metron >
  • What is Metronide (Flagyl, Flagyl ER), and how does it work?
  • Why is Metronide prescribed to patients?
  • What are the side effects of Metronide?
  • What is the dosage for Metronide, and how do I take it?
  • Which drugs or supplements interact with this medication?
  • Is this drug safe to use during pregnancy or while breastfeeding?
  • What else should I know about Flagyl (Metronide)?

Metronide and Alcohol

Consuming alcohol while taking Metronide can cause unwanted symptoms, such as:

  • Upset stomach
  • Stomach cramps
  • Vomiting
  • Fast heartbeat
  • Headache
  • Flushing
  • Sweating

Don't drink alcohol while using this medicine, and for at least three days after you stop taking it.

Be sure to check the labels of foods and other products to make sure they don't contain alcohol.

Metronide Overdose

Symptoms of a Metronide overdose may include:

  • Dizziness
  • Nausea
  • Vomiting
  • Loss of coordination or balance
  • Seizures
  • Numbness or tingling

If you suspect an overdose, contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at 800-222-1222.

Central Nervous System

The most serious adverse reactions reported in patients treated with Metronide have been convulsive seizures, encephalopathy, aseptic meningitis, optic and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity. Since persistent peripheral neuropathy has been reported in some patients receiving prolonged administration of Metronide, patients should be specifically warned about these reactions and should be told to stop the drug and report immediately to their physicians if any neurologic symptoms occur. In addition, patients have reported headache, syncope, dizziness, vertigo, incoordination, ataxia, confusion, dysarthria, irritability, depression, weakness, and insomnia (see WARNINGS).

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Metronide tablets, cream, gel, suppositories or vaginal gel. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

The Metronide immediate-release tablet and extended-release tablet are prescription drugs. They’re both taken by mouth. These tablets are available as the brand-name drugs Flagyl (immediate-release) and Flagyl ER (extended-release).

Immediate-release drugs are released into the body right away. Extended-release drugs are released into the body slowly over time.

Both the immediate-release and extended-release tablets are available as generic drugs. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Contraindications

Hypersensitivity to Metronide or other nitroimidazoles (although cautious desensitization has been applied)

Pregnancy, 1st trimester in patients with trichomoniasis

Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy

How should I take Metronide?

Take Metronide exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

If you are treating a vaginal infection, your sexual partner may also need to take Metronide (even if no symptoms are present) or you could become reinfected.

Metronide is usually given for up to 10 days in a row. You may need to repeat this dosage several weeks later.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Metronide will not treat a viral infection such as the flu or a common cold.

Metronide can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

Store at room temperature away from moisture and heat.


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