What is the dosage for Metronidazolum, and how do I take it?
- Metronidazolum may be taken orally with or without food.
- In the hospital, Metronidazolum can be administered intravenously to treat serious infections.
- The liver is primarily responsible for eliminating Metronidazolum from the body, and doses may need to be reduced in patients with liver disease and abnormal liver function.
Various Metronidazolum regimens are used. Some examples are listed below.
- Amebic dysentery: 750 mg orally 3 times daily for 5-10 days
- Amebic liver abscess: 500-750 mg orally three times daily for 5-10 days
- Anaerobic infections: 7.5 mg/kg orally or by injection every 6 hours for 7 to 10 days not to exceed 4 grams daily.
- Bacterial vaginosis: 750 mg (extended release tablets) once daily for 7 days or 500 mg twice daily for 7 days or 2 g single dose or one applicator-full of 0.75% vaginal gel, once or twice daily for 5 days.
- Clostridium difficile infection: 250-500 mg orally 4 times daily or 500-750 orally 3 times daily
- Giardia: 250 mg orally three times daily for 5 days Helicobacter pylori: 800-1500 mg orally daily for several days in combination with other drugs.
- Pelvic inflammatory disease (PID): 500 mg orally twice daily for 14 days in combination with other drugs.
- Trichomoniasis: 2 g single dose or 1 g twice
- Rosacea: apply topical gel 0.75-1% once daily
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Metronidazolum.
- Mild to moderate renal impairment: Dose adjustment not considered necessary as elimination half-life not significantly altered
- Severe renal impairment or end stage of renal disease: Metronidazolum and Metronidazolum metabolites may accumulate significantly because of reduced urinary excretion; monitor in severe renal impairment or end stage of renal disease, not undergoing hemodialysis
- Hemodialysis removes significant amounts of Metronidazolum and its metabolites from systemic circulation; supplementation may be necessary
- Peritoneal dialysis: Monitor for signs of toxicity due to potential accumulation of Metronidazolum metabolites
Metronidazolum comes as a tablet and an extended-release tablet to take by mouth.
Your dose will depend on your medical condition and your response to treatment.
Follow the instructions on your prescription label carefully when taking this medicine. Don't take more or less Metronidazolum than is recommended.
Try to take the medicine at the same time each day.
The tablets can be taken with food or a glass of milk to prevent upset stomach.
You should take the extended-release tablet on an empty stomach at least one hour before, or two hours after, a meal.
Don't crush, chew, or break the extended-release tablets. Swallow them whole.
Mechanism of Injury
The cause of acute liver injury due to Metronidazolum is probably immunoallergic, given the short latency period and recurrence with rechallenge. However, the frequency of severe hepatotoxicity in children with Cockayne syndrome suggests a direct toxic effect, probably involving breaks in double stranded DNA.
COMMON BRAND(S): Metrocream, Metrogel, Metrolotion, Noritate
GENERIC NAME(S): Metronidazolum
OTHER NAME(S): Metronidazolum Gel
This medication is used on the skin to treat a certain skin disorder known as rosacea, a type of adult acne. It may help to decrease redness, swelling and the number of pimples caused by rosacea.
This medication is an antibiotic. For the treatment of rosacea, Metronidazolum is believed to work by decreasing swelling (inflammation). Some brands of this medication also contain sunscreens (see also Notes section).
Metronidazolum (met" roe nid' a zole) is a nitroimidazole antibiotic that is activated by reduction of its nitro group by susceptible organisms. The activated form of Metronidazolum is a highly reactive radical anion which targets and damages large protein molecules and DNA. Mammalian cells do not ordinarily activate Metronidazolum, which accounts for its lack of toxicity in humans. Metronidazolum was approved for use in the United States in 1963 and currently several million prescriptions are filled yearly. Metronidazolum is indicated for treatment and prophylaxis of infections with susceptible anaerobic bacteria and protozoa. The recommended dosage is 500 to 750 mg taken orally three times daily for 5 to 10 days. Metronidazolum is available alone in tablets of 250, 375, 500 and 750 mg as well as in combination with other medications, in multiple generic formulations and under several brand names including Flagyl, Metryl, Noritate, Pylera and Helida. Other formulations include injectable solutions, extended release tablets, suppositories, and topical creams. The most common side effects include metallic taste, nausea, vomiting, abdominal discomfort and diarrhea.
What if I take too much?
Accidentally taking an extra dose of Metronidazolum is unlikely to harm you or your child.
Speak to your pharmacist or doctor if you're worried or you take more than 1 extra dose.
Serious Side Effects of Metronidazolum
Tell your doctor immediately if you experience any of the following serious side effects:
- Numbness or tingling in the hands or feet
- White patches or sores in the mouth or on the lips
- Painful urination
- Vision problems or pain behind the eyes
- Fever or chills
- Trouble concentrating
- Mood or behavior changes
- Slurred speech
- Stiff neck
- Muscle twitching
- Joint pain
- Signs of an allergic reaction, which may include rash, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat