Mepastat

Mepastat

  • Active Ingredient: Medroxyprogesterone
  • 10 mg, 5 mg, 2.5 mg
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What is Mepastat?

The active ingredient of Mepastat brand is medroxyprogesterone. Medroxyprogesterone is a progestin (a form of progesterone), a female hormone that helps regulate ovulation (the release of an egg from an ovary) and menstrual periods. Each Medroxyprogesterone acetate tablet for oral administration contains 2.5 mg, 5 mg or 10 mg of Medroxyprogesterone acetate and the following inactive ingredients: calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose, and talc. The 2.5 mg tablet contains FD&C Yellow No. 6.

Used for

Mepastat is used to treat diseases such as: Abnormal Uterine Bleeding, Amenorrhea, Birth Control, Endometrial Cancer, Endometrial Hyperplasia, Prophylaxis, Endometriosis, Gender Dysphoria, Renal Cell Carcinoma.

Side Effect

Possible side effects of Mepastat include: pimples; troubled breathing at rest; headache; pain in the chest, groin, or legs, especially the calves; chills; unexpected or excess milk flow from the breasts; irritability.

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Mepastat Interactions

Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take thyroid medications including:

  • liothyronine (Cytomel)
  • liotrix (Thyrolar)
  • levothyroxine (Levothroid, Levoxyl, Synthroid, Tirosint, Unithroid)
  • thyroid (Armor Thyroid, Nature-Thyroid, Westhroid)

This is not a complete list of Mepastat drug interactions. Ask your doctor or pharmacist for more information.

Provera Dosage

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Mepastat is usually given for only a few days in a row each month. You may need to start taking the medication on a certain day of your menstrual cycle, depending on why you are taking Mepastat. Follow your doctor's instructions.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Mepastat.

This medicine can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are taking Mepastat.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Copyright 1996-2019 Cerner Multum, Inc.

Latest Update: 11/9/2018, Version: 7.03

Mepastat may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • breasts that are tender or produce a liquid
  • changes in menstrual flow
  • irregular vaginal bleeding or spotting
  • acne
  • growth of hair on face
  • loss of hair on scalp
  • difficulty falling asleep or staying asleep
  • drowsiness
  • upset stomach
  • weight gain or loss

How should I take Mepastat?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Mepastat is usually given for only a few days in a row each month. You may need to start taking the medication on a certain day of your menstrual cycle, depending on why you are taking Mepastat. Follow your doctor's instructions.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Mepastat.

This medicine can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are taking Mepastat.

Store at room temperature away from moisture and heat.

What should I discuss with my healthcare provider before taking Mepastat?

Mepastat can cause birth defects. Do not use if this medicine you are pregnant. Tell your doctor right away if you become pregnant during treatment.

You should not use this medicine if you are allergic to Mepastat, or if you have:

  • abnormal vaginal bleeding that has not been diagnosed;
  • a hormone-related cancer such as breast or uterine cancer;
  • liver disease; or
  • a history of stroke or blood clot.

To make sure Mepastat is safe for you, tell your doctor if you have:

Mepastat may increase your risk of developing a condition that can lead to uterine cancer. To help lower this risk, your doctor may prescribe a progestin for you to take with Mepastat. Report any unusual vaginal bleeding right away.

Mepastat can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Mepastat will not prevent heart disease, breast cancer, or dementia, and may actually increase the risk of developing these conditions in post-menopausal women. Mepastat may also increase the risk of uterine or ovarian cancer in some women. Long-term treatment with estrogens and progestins (such as Mepastat) may also increase your risk of heart attack, blood clot, or stroke.

Talk to your doctor about your specific risks and benefits of taking this medicine, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

How should this medicine be used?

Mepastat comes as a tablet to take by mouth. It is usually taken once a day on certain days of a regular monthly cycle. To help you remember to take Mepastat, take it at around the same time every day on the days you are scheduled to take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Mepastat exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Mepastat may control your condition but will not cure it. Continue to take Mepastat according to your monthly schedule even if you feel well. Do not stop taking Mepastat without talking to your doctor.

Inform MD

Tell your healthcare provider:

  • If you are breastfeeding. The hormone in Mepastat can pass into your breast milk.
  • About all of your medical problems. Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing); epilepsy (seizures); migraine headaches; endometriosis (severe pelvic pain); lupus; problems with your heart, liver, thyroid, or kidneys; or if you have high calcium levels in your blood.
  • About all the medicines you take. This includes prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how Mepastat works. Mepastat may also affect how other medicines work.
  • If you are going to have surgery or will be on bed rest. If you are taking estrogen in addition to Mepastat, you may need to stop taking estrogen and Mepastat.

WHAT IS MEDROXYPROGESTERONE?

Mepastat is in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones.

Mepastat is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. It can also be used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause.

This medicine is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen.

Tell your doctor if you have any of the following: high blood pressure, angina, or heart disease; had a stroke; a history of unusual bleeding or blood-clotting; liver disease; kidney disease; a personal or family history of breast cancer, uterine, or another hormone-related cancer; undiagnosed, abnormal vaginal bleeding; a history of intracranial hypertension (increased blood pressure in the head); problems with the eyes; osteoporosis; depression; migraines; diabetes; asthma; seizures or epilepsy. You may not be able to use Mepastat or you may require special monitoring during treatment if you have any of the conditions listed above.

Women who use Mepastat may lose significant bone mineral density. Bone loss is greater the longer the drug is used and may not be completely reversible. It is unknown if the use of Mepastat in adolescents or young adults will reduce bone mass and increase the risk for osteoporotic fracture in later life. Women should only use Mepastat as a long-term birth control method (longer than two years) if other birth control methods are inadequate.

If you are switching from the pill, patch or ring form of contraception to an injectable form of Mepastat contraception, the first injection should be administered within 7 days after taking the last active pill or removing the patch or ring. Similarly, contraceptive coverage can be maintained when switching from one form of injectable Mepastat to another if the next injection is given within your current scheduled dosing period. Talk to your doctor if you have any questions regarding your contraceptive coverage when switching products.

Mepastat is in the FDA pregnancy category X. This means that Mepastat is known to cause birth defects in an unborn baby. Hormonal changes during pregnancy can have serious negative effects on a developing baby. Notify your doctor immediately if you think you might be pregnant.

Additionally, this drug passes into breast milk but does not appear to affect a nursing baby. Talk to your doctor before using Mepastat if you are breast-feeding a baby.

Avoid smoking cigarettes during treatment with Mepastat. Smoking may increase the risk of developing a heart attack, stroke, or blood clot.

Mepastat contraceptive does not offer protection from sexually transmitted diseases including HIV and AIDS. Using a condom is the only way to obtain protection from these diseases.

What should I do if I forget a dose?

If a dose of Mepastat contraceptive is missed or delayed past the 3 month interval, another form of birth control should be used to ensure contraceptive protection. Contact your healthcare provider if a dose is missed or delayed.

On the other hand, contact your doctor if a dose of Mepastat is missed when being used in the treatment of cancer.

What side effects can this medication cause?

What other drugs will affect Mepastat?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • bosentan, griseofulvin, St. John's wort;
  • an antibiotic or antifungal medicine;
  • HIV or AIDS medicine;
  • seizure medicine; or
  • sleep medicine (to treat insomnia).

This list is not complete. Other drugs may interact with Mepastat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

PRODUCT INFORMATION

REPRESENTATIVE TRADE NAMES

Mepastat – Generic, Provera® , Depo-Provera®

Product labeling at DailyMed, National Library of Medicine, NIH

Mepastat Acetate

Mepastat acetate up to 10 mg orally per day, or depot Mepastat acetate 150 mg intramuscular every 3 months can induce amenorrhea. Depot Mepastat acetate given subcutaneously every 12 weeks has also been approved by the FDA for treatment of endometriosis-associated pain. 229

The effectiveness of progestin-only therapy is similar to that with continuous COCs. 230 The clinical benefit of progestins in the treatment of endometriosis-associated pain was shown in a multicenter, randomized trial where the use of subcutaneous depot Mepastat acetate was comparable to a intramuscular depot GnRH agonist in reducing dysmenorrhea, dyspareunia, pelvic pain, pelvic tenderness, and pelvic induration. 231 The oral or depot administration of Mepastat acetate at these doses introduces large systemic quantities of a progestin and is associated with an unfavorable side-effect profile.


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