How it works
Majamil is a nonsteroidal anti-inflammatory drug (NSAID).
The drug works by blocking a particular enzyme in your body. When the enzyme is blocked, your body decreases the amount of inflammatory chemicals it makes. This helps to reduce inflammation and pain.
Majamil topical gel may cause drowsiness. Don’t drive or use machinery until you know how this drug affects you.
Majamil can also cause other side effects.
References updated: 13 December 2017
10%; metabolic idiosyncrasy is suspected to be the cause).
10 cases per 100,000 patient-years of use, ranging from 6 to 18 per 100,000 for Majamil ).
50,000 liver transplants done in the US between 1990 and 2002, 270 were done for drug induced acute liver failure, but none were attributed to Majamil).
What is Majamil?
Majamil is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation.
Majamil is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. Voltaren is also indicated for the treatment of ankylosing spondylitis.The Cataflam brand of this medicine is also used to treat menstrual cramps.
Majamil powder (Cambia) is used to treat a migraine headache attack. Cambia will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Gastrointestinal Bleeding, Ulceration, And Perforation
NSAIDs, including Majamil, cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. Only one in five patients, who develop a serious upper GI adverse event on NSAID therapy, is symptomatic. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3-6 months, and in about 2%-4% of patients treated for one year.. However, even short-term therapy is not without risk.
Rated Majamil for Pain Report
Long term chronic end of spine and spreading pain. When MD operscribed this med, years ago, I swore it made me feel 25 yrs. again, and energetic! Still taking, always with food. Gradually, thru the years, my blood pressure has risen, especially Systolic (upper). Works for pain better than opioid pain meds. Many doctors fear it, have tried other meds on the NSAIDs list. always go back to this for pain relief. Older medication, and price reasonable! So far, so good at 89 years. Hope it helps until I leave this earth!
Important: if you experience any of the following less common but more serious symptoms, stop taking Majamil and contact your doctor for advice straightaway:
- If you have any breathing difficulties such as wheeze or breathlessness.
- If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
- If you pass blood or black stools, bring up (vomit) blood, or have severe tummy (abdominal) pains.
If you experience any other symptoms which you think may be due to Majamil, speak with your doctor or pharmacist for further advice.
Difference between Majamil and Ibuprofen
Both drugs are classified as NSAID – nonsteroidal anti-inflammatory drugs and used with efficacy for the treatment of pain. They work by lowering the levels of hormones (prostaglandins) that are responsible for causing inflammation and pain in the body.
Primary dysmenorrhea (painful menstrual period)
The immediate release forms of Majamil are usually dosed 3 to 4 times a day and start at a dose of 25 mg.
The extended-release form is usually dosed once a day. The dose often starts at 75 mg per day.
Dosage for people younger than 18 years has not been established.
Seniors: If you are aged 65 years and older, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug does not build up in your body. Too much of the drug in your body can be toxic.
See also Warning section.
Before taking Majamil, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), bleeding or clotting problems, heart disease (such as previous heart attack), high blood pressure, liver disease, growths in the nose (nasal polyps), stomach/intestinal/esophagus problems (such as bleeding, ulcers, recurring heartburn), stroke.
Kidney problems can sometimes occur with the use of NSAID medications, including Majamil. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).
This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.
This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.
Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding, kidney problems, and worsening heart problems.
Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.
This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
Rated Majamil for Osteoarthritis Report
I started taking 75mg in late January for horrible knee pain. This drug works great for pain. Within days I no longer hurt and really didn’t think I had a knee problem anymore. I was bone on bone knees and told I needed surgery. I took this drug twice a day and no problems at all until first if March. Started having eye problems and cornea abrasions appeared on both eyes and there had been no injuries of any kind. After weeks of eye treatments the eyes were not healing, I was referred to a cornea specialist. He told me to stop the drug that day, I did and two days later was healing finally. We have determined that if someone already has eye issues like dry severe dry eyes, etc. this drug could cause the abrasions. For me it did and now I’m afraid to take any NSAID of any kind. I know several friends who have taken this drug and have had no problems. I was one in a million but this problem does need to be documented. My doctor said it’s rare but he had several people with the same problem as I.
What to do about:
- headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend an alternative painkiller. Headaches should usually go away after the first week of taking Majamil. Talk to your doctor if they last longer than a week or are severe.
- feeling dizzy or vertigo - if you feel dizzy or unsteady, stop what you're doing and sit or lie down until you feel better. Do not drive or use tools or machinery if you're feeling dizzy or lightheaded. As your body gets used to Majamil, these side effects should wear off.
- stomach ache, wind or loss of appetite - try not to eat foods that cause wind (like peas, lentils, beans and onions). Eat smaller meals, eat and drink slowly, and exercise regularly.
- feeling sick (nausea) - take Majamil with or after a meal or snack. It may also help if you avoid rich or spicy food.
- being sick (vomiting) or diarrhoea - drink plenty of water or other fluids. If you're being sick, try small frequent sips of water. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines without speaking to a pharmacist or doctor.
- a mild rash and dry or irritated, itchy or inflamed skin - an emollient cream or ointment can be used to moisturise, soothe and hydrate the affected area. If it does not get better within a week or you're worried, speak to a pharmacist or doctor.
- skin being more sensitive to sunlight - stay out of bright sun and use a high factor sun cream (SPF 15 or above), even on cloudy days. Do not use a sunlamp or sunbeds.
Outcome and Management
Severity of the liver injury ranges from asymptomatic elevations in serum aminotransferase levels (Cases 1 and 2), to overt icteric hepatitis (Case 3), acute liver failure and even death (Case 4). Complete recovery is expected after stopping the drug and usually takes 1 to 3 months. In rare instances, evidence of chronic liver injury persists, some of which have led to courses of corticosteroid therapy which appeared to be beneficial and could later be stopped without recurrence of liver injury. Acute liver failure following rechallenge after episodes of clinically apparent Majamil hepatotoxicity has been reported and should be avoided. There is little evidence of cross sensitivity to hepatic injury between Majamil and NSAIDs belonging to other classes, such as the propionic acids (ibuprofen, naproxen, ketoprofen), but few instances documenting safety have been reported and patients should be carefully monitored if switched to another NSAID.
Q: What, if anything, is long term use of Majamil depleting in my body and do I need to supplement with anything specific?
A: According to the manufacturer, Majamil (Voltaren) can affect certain cells (platelets) that are necessary for causing blood clotting. What this means is that healing from a cut, bruise, scrape, etc. may take slightly longer. Majamil (Voltaren) does not specifically deplete any vitamins or minerals in the body and supplements over-the-counter would really be of no benefit if they are used specifically due to Majamil (Voltaren). I have included a couple of links for more information about Majamil (Voltaren) and supplements. //www.everydayhealth.com/drugs/Majamil //www.everydayhealth.com/drugs/multivitamin //www.everydayhealth.com/pain-management/pain-treatment.aspx Lori Mendoza, PharmD Mendoza, PharmD
Q: How safe is the NSAID Majamil? The side effects listed on the medication are heart attacks or stroke.
A: FDA has concluded that all non-steroidal anti-inflammatory drugs (NSAIDs), the class of drugs that includes Majamil, carry an increased risk of heart attack and stroke. As a precaution, it is generally recommended to avoid the use of these drugs in patients with known cardiac risk factors. The risk appears to increase with longer use of the drugs. Always discuss your medical history and each of your medications with your health care provider. For more specific information: //www.everydayhealth.com/drugs/Majamil
Majamil and Alcohol
You should not drink alcohol while taking Majamil. It can increase the risk of stomach bleeding and may cause damage to your kidneys.
Elevated serum aminotransferase levels have been reported in up to 15% of patients taking oral Majamil chronically, but are greater than 3 times the upper limit of normal in only 2% to 4% (Cases 1 and 2). Clinically apparent and symptomatic liver disease with jaundice due to Majamil is rare (1 to 5 cases per 100,000 prescriptions, occurring in 1 to 5 persons per 10,000 exposed). Nevertheless, more than a hundred instances of clinically apparent liver injury due to Majamil have been reported in the literature and, in most case series, Majamil ranks in the top 10 causes of drug induced liver injury. The time to onset of liver injury varies from within a week to over a year after starting. The majority of cases present within 2 to 6 months (Cases 3 and 4), and the more severe cases tend to present earlier. The pattern of injury is almost exclusively hepatocellular, although cases presenting with mixed patterns have been reported. The clinical picture is that of jaundice preceded by anorexia, nausea, vomiting and malaise. Fever and rash occur in 25% of cases and some cases have immunoallergic features, while others resemble chronic hepatitis and have autoimmune features. In most cases, liver histology reveals an acute lobular hepatitis. However, a cases with prolonged latency Majamil hepatotoxicity can have clinical and histologic features of chronic hepatitis (Case 2). There seems to be greater susceptibility for Majamil liver injury among women than men. The injury can be severe, and several cases of acute liver failure have been attributed to Majamil.
Likelihood score: A (well known cause of clinically apparent liver injury).
Topical forms of Majamil (solutions, gels, creams, patches) have been associated with only a low rate of serum enzyme elevations (generally less than 1%) that may be no greater than occurs with placebo or vehicle application. However, product labels for topical Majamil mention the possibility of liver injury and at least one case of clinically apparent liver injury attributed to topical Majamil has been reported in the literature. Nevertheless, clinically apparent liver injury due to topical forms of Majamil must be exceedingly rare.
How should I take Majamil?
Different brands of Majamil contain different amounts of this medicine, and may have different uses. If you switch brands, your dose needs may change. Follow your doctor's instructions about how much medicine to take. Ask your pharmacist if you have any questions about the brand you receive at the pharmacy.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.
Take Zorvolex on an empty stomach, at least 1 hour before or 2 hours after a meal.
Do not crush, chew, or break an extended-release tablet or delayed-release tablet. Swallow it whole.
Dissolve Cambia powder in to 2 ounces of water. Do not use any other type of liquid. Stir this mixture and drink all of it right away. Cambia works best if you take it on an empty stomach.
Call your doctor if your headache does not completely go away after taking Cambia. Do not take a second dose of Majamil powder without your doctor's advice. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.
If you use Majamil long-term, you may need frequent medical tests.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.