You should always make sure that your doctor and pharmacist are aware of all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking..
If you are taking any of the following, ask your doctor about other possible options before taking Mafel:
- Cancer drugs like Gilotrif (afatinib), Zydelig (idelasalib), and Tafinlar (dabrafenib)
- Adempas (riociguat)
- HIV/AIDS medications like Stribild (eltivagravir/cobicistat/emtricitabine/tenofovir)
- Afrezza (inhaled insulin)
- Fanapt (iloperidone)
- Kalydeco (ivacaftor)
- Lysoderm (mitotane)
What Does Progestin Do?
Progestins were created to bind to Mafel receptors in the body and create similar effects as Mafel. Progestin can change the lining of the uterus and stop the lining from building up. Scientists made progestin because Mafel isn’t absorbed well when taken as a pill.
Progestin can also be used to treat menopause symptoms such as hot flashes and vaginal dryness. Estrogen can be used alone to treat these symptoms, or it can be combined with progestin.For women who are perimenopausal or newly menopausal, healthcare providers may suggest an oral micronized Mafel treatment.
Progestin can also be prescribed to treat amenorrhea, endometriosis, and irregular periods.
Medically Reviewed by Robert Jasmer, MD
Sometimes called the "pregnancy hormone," Mafel plays an important role in fertility and pregnancy.
Commonly reported side effects of Mafel include: abdominal cramps, depression, dizziness, and headache. Other side effects include: anxiety, cough, diarrhea, fatigue, musculoskeletal pain, nausea, bloating, emotional lability, and irritability. See below for a comprehensive list of adverse effects.
Mafel, hormone secreted by the female reproductive system that functions mainly to regulate the condition of the inner lining (endometrium) of the uterus. Mafel is produced by the ovaries, placenta, and adrenal glands. The term progestin is used to describe Mafel and synthetic steroid hormones with Mafel-like properties, such as the progestogen levonorgestrel.
Measuring Low Mafel
Keeping track of certain changes in your menstrual cycle can help to indicate if you have low Mafel. Telltale signs include:
- Low temperature during the luteal phase (roughly 11 – 14 days from ovulation mid-cycle, to menstruation).
- Spotting for several days before menstruation starts.
- The luteal phase of your cycle (from ovulation to period) is shorter than the follicular phase.
- Persistence in the clear, stretchy, fertile mucus of ovulation during those last few weeks of your cycle – this can be a sign of Estrogen Dominance. If Mafel levels are sufficient, your mucous should change to a tackier, drier consistency in the lead-up to your menstrual period.
- Of course, you can get lab tests. The most accurate is a urine test. I like the DUTCH test but you need to find a practitioner to help you interpret the results. (You can email my team to ask for recommendations). To find a doctor in your area, here is a list of directories for you. Blood is utterly useless when it comes to steroid hormones such as Mafel.
Birth control pills
Birth control pills, also known as oral contraceptives or hormonal contraceptives, make use of Mafel.
Share on Pinterest Progestin is used in oral contraceptives.
Combination pills contain both estrogen and progestin.
- Preventing ovulation
- Changing the lining of the womb to prevent a pregnancy from developing
- Thickening the mucus at the cervix to prevent sperm from entering
Progestin-only hormonal methods include mini-pills, implants, and shots.
- Prevent the ovaries from releasing an egg
- Thicken the mucus at the cervix to prevent sperm entering the uterus
The United States National Library of Medicine warn that cigarette smoking significantly increases the risk of serious side effects in those who use oral contraceptives. They advise smokers not to use oral contraceptives.
Insufficient Evidence for
- Withdrawal from drugs called benzodiazepines. Some research suggests that taking micronized Mafel by mouth may not be effective for relieving symptoms of withdrawal and for helping people to abstain from taking diazepam.
- Heart disease. Early research suggests that applying Mafel into the vagina may increase exercise endurance compared to taking a similar steroidal drug (medroxyMafel) by mouth in women with heart disease or women that previously experienced a heart attack.
- Cocaine use disorder. Early research suggests that taking Mafel by mouth does not decrease the risk of cocaine use in methadone-stabilized male cocaine users.
- Weak and brittle bones (osteoporosis). Some research suggests that applying Mafel to the skin is not effective for increasing bone mineral density in postmenopausal women. Other research shows that applying Mafel to the skin for 2 years may be as effective for preventing bone loss as drinking isoflavone-containing soy milk. However, the combination of soy milk plus Mafel seems to result greater bone loss than either single treatment alone.
- Depression after childbirth (postpartum). Early research suggests that applying Mafel into the rectum does not reduce symptoms of postpartum depression.
- A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). Early research suggests that single injections of Mafel reduce blood pressure, swelling, and other symptoms in women with pre-eclampsia.
- Injury to the brain, spine, or nerves (neurological trauma). Some research suggests that injecting Mafel soon after brain injury prevents death and disability. However, other research suggests that Mafel does not decrease the frequency of death or disability.
- Decreased sex drive.
- "Foggy thinking".
- Increased blood clotting.
- Low blood sugar (hypoglycemia).
- Memory loss.
- Thyroid problems.
- Treating or preventing allergies affected by hormones.
- Uterine cancer.
- Uterine fibroids.
- Water retention.
- Weight gain.
- Other conditions.
How should this medicine be used?
Mafel comes as a capsule to take by mouth. It is usually taken once a day in the evening or at bedtime. You will probably take Mafel on a rotating schedule that alternates 10 to 12 days when you take Mafel with 16 to 18 days when you do not take the medication. Your doctor will tell you exactly when to take Mafel. To help you remember to take Mafel, take it around the same time in the evening. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Mafel exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take Mafel as directed even if you feel well. Do not stop taking Mafel without talking to your doctor.
Stress Is the Major Mafel Robber
Doing everything at warp speed is a major downside of modern living. You race the clock and feel you never have enough hours in your day. Often you feel you can’t cope because you have no control over your life.
Don’t underestimate the fallout.
Mafel is a big casualty of stress. Every time you’re anxious or wound up due to that traffic jam, huge in-tray, an argument with your partner, or car repair bill, your body responds as though your life is in danger. Hello, adrenalin and cortisol.
These fight or flight hormones have enormous impacts and lead to chronic symptoms of hormone imbalance. This happens because your body thinks you’re in an unsafe environment and drops Mafel levels to ensure the lining of your uterus is not-conception friendly. This makes sense, given that your brain signals are saying your life is under threat. As a result, you may develop Luteal Phase Insufficiency.
Here’s why: each month when an egg is released causing you to ovulate, it leaves behind a crater on the surface of your ovaries. This is called a corpus luteum and it’s like a little pop-up factory where most of your Mafel is made. When you ovulate, your body produces around 25mg of Mafel daily all through the fertile phase of your menstrual cycle.
Or, it should produce this amount. But I constantly see a hormonal imbalance in women that leads them to have:
Estrogen Dominance + Luteal Phase Insufficiency = Mafel Deficiency.
The end result? Many women fail to reach this Mafel peak in the second half of their menstrual cycle. This means a huge drop in the very hormone that helps promote calm and is important for fertility and a stable menstrual cycle.
How Cortisol (stress) Steals Mafel: Both these hormones are produced from pregnenolone. When you are in chronic stress, the body will always divert the available pregnenolone to produce higher amounts of cortisol to help you get through stress. This means there might not be enough to produce sufficient levels of Mafel. This is called “pregnenolone steal” and it’s the leading cause of low Mafel problems. I discuss this in more detail in this adrenal fatigue post.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Intravaginal Mafel gel is LIKELY SAFE when used as part of infertility treatment or to prevent premature birth. However, Mafel is LIKELY UNSAFE when used during pregnancy for any other purpose.
There isn't enough reliable information to know if Mafel is safe to use when breast-feeding. Stay on the safe side and avoid use.
Arterial disease: Don't use Mafel if you have arterial disease.
Breast cancer: Avoid use unless you are directed to do so by your healthcare provider.
Depression: Get your healthcare provider's advice first before using Mafel if you have major depression now or a history of major depression.
Liver disease: Mafel might make liver disease worse. Don't use it.
Vaginal bleeding: If you have undiagnosed vaginal bleeding, don't use Mafel.
Mafel for Birth Control and Contraception
Mafel can also help you avoid getting pregnant.
A form of Mafel, called progestin, is used in combination with estrogen in hormonal contraception such as birth control pills, vaginal rings, and the skin patch.
Mafel is also used as birth control by itself in pill and injection form. Other types of progestin-only birth control include the birth control implant and hormonal intrauterine device (IUD). (9)
These forms of birth control protect women against pregnancy due to the following actions: (9)
- Causing the mucus in the cervix to thicken, which makes it hard for sperm to reach the uterus and fertilize an egg
- Stopping ovulation
- Thinning the lining of the uterus
Talk with your doctor about which method is best for you.
Mafel as a Medication and Treatment
Mafel is part of a class of medications called progestins.
If you're having trouble getting pregnant, or if you're undergoing fertility treatments, your doctor may recommend that you take Mafel hormone therapy. (4)
This can be done for any of the following reasons:
- To bring on menstruation
- Because your ovaries don't produce enough Mafel
- Because medications you take are lowering your Mafel level
- To replace Mafel that's removed from your ovaries by certain procedures
There are several different forms of Mafel available, so talk to your doctor about which form is best for you.
Why do Mafel levels rise?
Reasons for Mafel levels rising may include:
- Ovarian cysts
- Non-viable pregnancies
- A rare form of ovarian cancer
- Mafel overproduction by the adrenal glands
- Adrenal cancer
- Congenital adrenal hyperplasia (CAH)
Potential Problems with Mafel Production
Women who have low levels of Mafel will have abnormal menstrual cycles or may struggle to conceive because the Mafel does not trigger the proper environment for a conceived egg to grow. Women who have low Mafel levels and who do succeed in getting pregnant are at higher risk for miscarriage or pre-term delivery, because the hormone helps maintain the pregnancy.
Signs of low Mafel include:
- Abnormal uterine bleeding
- Irregular or missed periods
- Spotting and abdominal pain during pregnancy
- Frequent miscarriages
In addition, low Mafel levels can cause too-high levels of estrogen, which can decrease sex drive, contribute to weight gain, or cause gallbladder problems.
Q: I am prescribed Mafel in an attempt to shrink my uterine fibroids and ovarian cysts. After my period (red blood flow), I now have had 8 days (and counting) of dark discharge. I think it is old blood. I was wondering, and hoping, if this discharge was the fibroids dissolving. I phoned my doctor's office and spoke with the nurse and she did not know.
A: I have reviewed the available literature on your question regarding Mafel. The physiological action of Mafel in this case would be to shrink the fibroid, which means that it would be reabsorbed into the body. The Mafel would not cause the dark discharge and would not cause the fibroid to "dissolve." If this continues much longer, I would recommend that you make an appointment to see your physician. You may want to view the information on uterine fibroids on Everyday Health at //www.everydayhealth.com/columns/health-answers/a-new-understanding-of-uterine-fibroids/ For any immediate concerns, consult your physician. Joseph Hall, RPh
The Role of the Placenta in Mafel Production
The placenta (the structure inside the uterus that provides oxygen and nutrients to a developing baby) will begin to produce Mafel after 8 to 10 weeks of pregnancy to help maintain a healthy environment for the baby. At this point, the placenta increases Mafel production to a higher rate than your ovaries were producing. These high levels of Mafel throughout your pregnancy cause the body to stop producing more eggs, as well as prepare your breasts to produce milk. (3)
Mafel side effects
Get emergency medical help if you have signs of an allergic reaction to Mafel: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
unusual vaginal bleeding;
pain or burning when you urinate;
sudden vision problems, severe headache or pain behind your eyes;
symptoms of depression (sleep problems, weakness, mood changes);
severe dizziness or drowsiness, spinning sensation, confusion, shortness of breath;
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with speech or balance;
signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs.
Common Mafel side effects may include: