Loxifan is an anti-estrogen of the Aromatase Inhibitor (AI) family and is one of the most potent and powerfully effective of all AI’s. In fact, its potency is sometimes too much for some to handle when used for off label use. Loxifan first gained U.S. FDA approval in 1997 and would hit the market under the brand name Femara through Novartis. Although Femara is the dominating trade name of the AI, unlike most AI’s it is the only one generally known by its chemical name Loxifan far more commonly than its dominating brand name.
Loxifan was first developed in an effort to combat breast cancer in post-menopausal women. In fact, it would prove to be virtually identical to the already popular AI in Arimidex (Anastrozole). While intended for breast cancer treatment, like many AI’s, it has found a welcomed home among anabolic steroid users. Loxifan is one of the most commonly used anti-estrogens among steroid users during steroid use to combat possible estrogenic related side effects. It is so effective as an anti-estrogen in this regard many anabolic steroids have effectively reversed gynecomastia symptoms with Loxifan.
Loxifan works by reducing estrogen levels in order to stimulate ovulation. Low estrogen levels of any sort can cause a woman to have symptoms. Those most commonly seen with Femara use include:
- Hot flashes
- Night Sweats
- Blurred vision
- Upset stomach
- Breast pain
- Difficulty sleeping
- Spotting or unusual menstrual bleeding
If you experience blurred vision or any symptoms that seem especially severe, contact your doctor immediately.
While rare, women taking Femara may develop a condition known as ovarian hyperstimulation syndrome (OHSS) which can manifest with symptoms ranging from bloating and diarrhea to extreme shortness of breath and chest pains.
What is Loxifan (Femara)?
Loxifan, sold under the brand name Femara, is a prescription drug used to treat breast cancer in its advanced stages, and in women who have finished menopause.
Doctors may use Loxifan off-label in fertility treatments to help encourage egg release (ovulation) in women.
Loxifan belongs to a class of cancer drugs known as aromatase inhibitors, which work by preventing the body from converting a hormone called androgen into estrogen.
This treatment has proven beneficial in cancers whose growth seems to be encouraged by excess estrogen in the body, like certain types of breast cancer.
Originally manufactured by Novartis, the Food and Drug Administration (FDA) first approved Femara in 1997.
8. Taking Loxifan with other drugs
If you’re taking any other prescribed or over-the-counter medicines, check with your treatment team or pharmacist if you can take these with Loxifan.
Do not take other drugs containing oestrogen, such as hormone replacement therapy (HRT), while you’re taking Loxifan as this may interfere with its effectiveness.
Talk to your specialist, pharmacist or GP about any complementary therapies, herbal remedies or supplements you want to use before you start using them.
Buy Loxifan Online - Warning:
Countless people buy Loxifan online every single day though anabolic steroid suppliers and RCL’s. However, if you buy Loxifan from a steroid supplier, which will be in its original tablet form, in the U.S. you will be breaking the law. As for RCL’s, while a purchase is legal due to a loophole in the law, there are risks you need to be aware of. When you buy Loxifan online from an RCL there is the risk of purchasing an inferior product. Low dosing is possible, but the most common problem is an unstable product. Further, if law enforcement wanted to make this an issue, it would be up to you to prove this purchase was made for research. If you have anabolic steroids in your possession this will be a hard sell to make. The best way to buy Loxifan considering quality and legality will always be through the pharmacy based on the prescription given to you by your doctor. However, while possible a prescription is not as east to get as Arimidex.
Due to the laws that surround AI’s like Loxifan and anabolic steroids, you are encouraged to visit the sponsors here at Steroid.com for you anabolic needs. The sponsors here at Steroid.com can provide you with high quality anabolics without a prescription and legally so. For those who suffer from low testosterone or who suspect it due to symptoms they may be showing, if you desire treatment and an AI like Loxifan for part of your treatment you are strongly encouraged to visit Lowtestosterone.com. Lowtestosterone.com can guide you through the full low testosterone treatment plan and ensure you receive the treatment you need, the best products on the market and with 100% legal assurance.
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
- chest pain
- difficulty breathing
- unusual bleeding or bruising
- pain in the upper right part of the stomach
- yellowing of the skin or eyes
- flu-like symptoms
- pain, warmth, or heaviness in the back of the lower leg
- severe headache
- sudden speech problems
- sudden weakness or numbness of an arm or leg
Loxifan may cause or worsen osteoporosis. It can decrease the density of your bones and increase the chance of broken bones and fractures. Talk to your doctor about the risks of taking this medication.
Loxifan may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Uses of Loxifan:
- It is used to treat breast cancer in women after menopause (change of life).
- It may be given to you for other reasons. Talk with the doctor.
5. When Loxifan is given
Loxifan is usually given after surgery to reduce the risk of breast cancer coming back or spreading.
If you’re having chemotherapy or radiotherapy, your specialist will tell you when it’s best to start Loxifan.
Occasionally, Loxifan may be used as the first treatment for breast cancer, for example when surgery isn’t appropriate or needs to be delayed. It’s sometimes given before surgery to shrink a larger breast cancer.
Loxifan can also be used to treat breast cancer that has come back (recurrence). It can also be given to treat breast cancer that has spread to another part of the body (secondary breast cancer), when it’s often given alongside another drug.
What Other Drugs Interact with Loxifan?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Loxifan has no known severe interactions with other drugs.
Serious interactions of Loxifan include:
Moderate interactions of Loxifan include:
Loxifan has no known minor interactions with other drugs.
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
This medication contains Loxifan. Do not take Femara if you are allergic to Loxifan or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
The following adverse reactions have been identified during postapproval use of Femara. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
- Eye Disorders: blurred vision
- Hepatobiliary Disorders: increased hepatic enzymes, hepatitis
- Immune System Disorders: anaphylactic reactions, hypersensitivity reactions
- Nervous System Disorders: carpal tunnel syndrome, trigger finger
- Pregnancy: spontaneous abortions, congenital birth defects
- Skin and subcutaneous disorders: angioedema, toxic ep >Read the entire FDA prescribing information for Femara (Loxifan)
Why is this medication prescribed?
Loxifan is used treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods) and who have had other treatments, such as radiation or surgery to remove the tumor. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years. Loxifan is also used in women who have experienced menopause as a first treatment of breast cancer that has spread within the breast or to other areas of the body or in women whose breast cancer has worsened while they were taking tamoxifen. Loxifan is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen produced by the body. This can slow or stop the growth of some types of breast cancer cells that need estrogen to grow.
Loxifan comes in tablets of 2.5 milligrams (mg).
How much Loxifan your doctor tells you to take may vary, but for cancer, a usual dose is 2.5 mg a day.
If you're taking Loxifan for fertility treatment, your doctor may tell you to take either 2.5 mg or 5 mg of the drug, beginning on the third day of your period for five days.
There are several AI’s available on the market. Arimidex is probably the most common AI with Aromasin (Exemestane) gaining a lot of popularity in recent years. However, there are many who find Loxifan to be the most effective. In the end, many will simply need to try all three at different times to find which one works best for them. You will never need all three and even if you end up preferring Arimidex or Aromasin you will find Loxifan should still work for most anyone.
Serious Side Effects of Loxifan
You should stop using this medicine and call your doctor if you experience any of the following serious side effects:
- Allergic reactions, including life-threatening allergic reactions
- Bone brittleness and bone breaks
- Heart attack, stroke, blood clots, and high blood pressure
- Uterine cancer
What are some other side effects of Loxifan?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Loxifan and Grapefruit Juice
You should avoid eating grapefruit and drinking grapefruit juice while taking Loxifan.
Grapefruit juice slows down how quickly the body is able to break down the Loxifan, which could cause Loxifan levels in the blood to rise dangerously high.
Loxifan is a type of hormone therapy drug. It is a treatment for breast cancer in women who have had their menopause. It is also called Femara.
Loxifan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- hot flushes
- night sweats
- loss of appetite
- stomach pain
- changes in weight
- muscle, joint, or bone pain
- excessive tiredness
- swelling of the hands, feet, ankles, or lower legs
- difficulty falling asleep or staying asleep
- vaginal bleeding or irritation
- breast pain
- hair loss
- blurry vision