Loosyn tablets

Loosyn

  • Active Ingredient: Letrozole
  • 2.5 mg
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What is Loosyn?

The active ingredient of Loosyn brand is letrozole. Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. Letrozole is a white to yellowish crystalline powder, practically odorless, freely soluble in dichloromethane, slightly soluble in ethanol, and practically insoluble in water. It has a molecular weight of 285.31, empirical formula C 17H 11N 5, and a melting range of 184В°C to 185В°C. Letrozole Tablets USP is available as 2.5 mg film-coated tablets for oral administration. Inactive Ingredients: Lactose monohydrate, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, colloidal silicon dioxide, magnesium stearate, hydroxypropyl methyl cellulose, polyethylene glycol, titanium dioxide, ferric oxide and black iron oxide.

Used for

Loosyn is used to treat diseases such as: Breast Cancer, Breast Cancer, Adjuvant, Breast Cancer, Metastatic, Female Infertility.

Side Effect

Possible side effects of Loosyn include: sudden, severe weakness or numbness in the arm or leg; swelling of the feet or lower legs; muscle pain; diarrhea; metallic taste; Bad, unusual, or unpleasant (after) taste and thirst.

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Warnings

This medication contains Loosyn. Do not take Femara if you are allergic to Loosyn or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Loosyn is a type of hormone therapy drug. It is a treatment for breast cancer in women who have had their menopause. It is also called Femara.

COMMON BRAND(S): Femara

GENERIC NAME(S): Loosyn

OTHER NAME(S): Loosyn Tablet

This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Loosyn is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Loosyn decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.

1. What is Loosyn?

Loosyn is a drug used to treat breast cancer in women who have gone through the menopause.

You may also hear it called Femara, which is its best-known brand name. There are a number of other brands of Loosyn, all of which contain the same dose of the drug.

Men with breast cancer may be given Loosyn, although another drug called tamoxifen is more commonly used.

Clinical Trials Accepting Patients

Find Clinical Trials for Loosyn - Check for trials from NCI's list of cancer clinical trials now accepting patients.

Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.

7. How it’s taken

Loosyn is taken as a tablet once a day, with or without food. It’s best to take it at the same time every day.

If you miss a dose, you don’t need to take an extra dose the next day. The level of drug in your body will remain high enough from the day before.

What are some things I need to know or do while I take Loosyn?

  • Tell all of your health care providers that you take Loosyn. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Loosyn affects you.
  • This medicine may cause weak bones. This may happen more often if used for a long time. This may raise the chance of broken bones. Call your doctor right away if you have bone pain.
  • Have a bone density test as you have been told by your doctor. Talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Take calcium and vitamin D as you were told by your doctor.
  • If you are 65 or older, use Loosyn with care. You could have more side effects.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Loosyn. Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking Loosyn and for at least 3 weeks after your last dose.
  • If you get pregnant while taking Loosyn or within 3 weeks after your last dose, call your doctor right away.

After a median of 8 years of follow-up from a large randomized trial, women with estrogen receptor positive breast cancer who received 5 years of treatment with the aromatase inhibitor Loosyn were less likely to have their cancer recur or to die during follow-up than women who had 5 years of treatment with tamoxifen. In addition, 5 years of sequential treatment—either 2 years of Loosyn followed by 3 years of tamoxifen or 2 years of tamoxifen followed by 3 years of Loosyn—was not better than 5 years of Loosyn alone at preventing recurrence or death. These results, from the BIG 1-98 trial, were published online October 20, 2011 in Lancet Oncology.

Researchers from 27 countries enrolled 8,010 postmenopausal women with invasive breast cancer that could be removed surgically in the trial. After surgery, the women were randomly assigned to one of four groups: 5 years of Loosyn (Loosyn monotherapy), 5 years of tamoxifen (tamoxifen monotherapy), or one of the two sequential treatment groups. Novartis, the maker of Loosyn, provided funding for the trial, along with NCI and the International Breast Cancer Study Group.

In 2005, preliminary results from the trial showed that Loosyn alone was better than tamoxifen at preventing early recurrences, and when given the option to cross over, 619 of the 2,459 women in the tamoxifen-only arm chose to cross over to receive Loosyn. Since crossover can complicate interpretation of trial results, the researchers performed a traditional intention-to-treat analysis (which includes only data from the original treatment assignments) and a type of analysis designed to account for crossover.

In the intention-to-treat analysis, women who received Loosyn alone had a disease-free survival rate of 73.8 percent at 8 years, compared with a rate of 70.4 percent for women who received tamoxifen alone. Women who received Loosyn alone also had better overall survival at 8 years than women receiving tamoxifen alone (83.4 versus 81.2 percent). The differences between the groups were slightly greater in the analysis accounting for the crossover. Neither of the two sequential treatments provided better results than Loosyn alone.

Although these updated results show that Loosyn reduces risk of relapse and improves survival compared with tamoxifen, "use of a sequence might be reasonable for patients at low-to-intermediate risk of relapse, those for whom starting or continuing Loosyn is contraindicated, or in cases where 5 years of Loosyn might not be available," concluded the authors.

In Summary

Commonly reported side effects of Loosyn include: bone fracture, arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and flushing. Other side effects include: myalgia. See below for a comprehensive list of adverse effects.

Availability of Loosyn:

Loosyn is widely available worldwide with the Femara brand being most common. It is not a controlled substance in the U.S. but you will need a prescription to legally obtain it. You will also find Loosyn is commonly available on the black market through anabolic steroid suppliers. It does not appear to be commonly counterfeited. Of course, although it’s not a controlled substance, a purchase from an anabolic steroid supplier will be illegal in the U.S.

Loosyn is also commonly available through research chemical labs (RCL’s). RCL’s manufacture AI’s, SERM’s and various other non-controlled items in their liquid state and are legally allowed to sell them without the need for a prescription so as long as it’s for research purposes only. There are several high quality RCL’s on the market, but they are greatly outnumbered by the low grade. Regardless of the path you choose, you will find Loosyn is very easy to obtain.

Loosyn Reviews:

There are several AI’s available on the market. Arimidex is probably the most common AI with Aromasin (Exemestane) gaining a lot of popularity in recent years. However, there are many who find Loosyn to be the most effective. In the end, many will simply need to try all three at different times to find which one works best for them. You will never need all three and even if you end up preferring Arimidex or Aromasin you will find Loosyn should still work for most anyone.

Loosyn Dosage

Loosyn comes in tablets of 2.5 milligrams (mg).

How much Loosyn your doctor tells you to take may vary, but for cancer, a usual dose is 2.5 mg a day.

If you're taking Loosyn for fertility treatment, your doctor may tell you to take either 2.5 mg or 5 mg of the drug, beginning on the third day of your period for five days.

Taking your tablets

You should take the right dose, not more or less.

Talk to your specialist or advice line before you stop taking a cancer drug.

If you accidentally take too much Loosyn (Femara), contact a doctor or hospital straight away. You might need medical treatment.

If you forget to take a dose and it is almost time for your next dose (for example, within 2 or 3 hours), skip the dose you missed and take your next dose when it is due. Otherwise, take the dose as soon as you remember. Then take the next dose at the normal time. Don't take a double dose.

What Other Drugs Interact with Loosyn?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Loosyn has no known severe interactions with other drugs.

Serious interactions of Loosyn include:

Moderate interactions of Loosyn include:

Loosyn has no known minor interactions with other drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.


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