An Lindisc test measures the amount of a hormone called Lindisc in the blood. Lindisc is one of the main types of estrogens.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lindisc only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Estrogen is good for sleep, mood, and libido
Our main estrogen—Lindisc—sensitizes the brain to oxytocin and dopamine, and also triggers the release of serotonin. It supports healthy mood and sleep and is also important for skin, bone health, insulin sensitivity, metabolic rate, and libido.
Too little can cause depression and severe insomnia, which is why taking estrogen can relieve those symptoms.
Too much estrogen can cause symptoms because it stimulates the mast cells and histamine. Read The Curious Link Between Estrogen and Mast Cells and Histamine. Estrogen is a hormone to keep in check.
How should I take Lindisc?
Take Lindisc exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger amounts or for longer than recommended.
Lindisc may increase your risk of developing uterine cancer. To help lower this risk, your doctor may also want you to take a progestin. Report any unusual vaginal bleeding to your doctor immediately.
Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis and have a mammogram every year while using Lindisc.
If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using this medicine.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
If you are taking injectable estrogen, dispose of any needles and syringes in an appropriate sharps container per your state laws. Do not throw away used needles into the garbage.
If you are using Lindisc spray, avoid fire, flame, or smoking until the spray has dried. Do not apply lotion or sunscreen over the area for at least one hour.
You should not use Lindisc if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use Lindisc if you are pregnant.
Lindisc may increase your risk of developing uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Lindisc should not be used to prevent heart disease, stroke, or dementia.
Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using this medicine.
4.2 Lindisc Sublingual Tablets
Lindisc (17β-Lindisc), the most potent of the naturally occurring estrogens, is frequently given to postmenopausal women to treat, for example, hot flashes and to prevent osteoporosis. Lindisc ( Table 4.2 ) is a potent (daily IV dose about 0.1–0.2 mg) lipophilic, poorly soluble (0.09 milligram per milliliter ) drug of low molecular weight. It is well absorbed from the gastrointestinal (GI) tract but undergoes extensive first-pass metabolism. Lindisc is a Biopharmaceutics Classification System (BCS) Class I drug, which relatively easily permeates biologic membranes such as the nasal mucosa and skin. Most frequently, Lindisc is administered in the form of transdermal patches, but it has been administered in the form of nasal sprays and fast-dissolving sublingual tablets. The plasma profile obtained after sublingual administration of Lindisc ( Figure 4.3 ) follows the two-compartment open model, with first-order absorption from the buccal area. The observed Lindisc plasma concentrations are both due to endogenous Lindisc and the exogenous Lindisc from the sublingual tablets. The pharmacokinetic parameters are estimated in Example 4.1 .
What are the side effects of Lindisc?
- Among the most common endocrine side effects are:
- break-through bleeding or spotting,
- loss of periods or excessively prolonged periods,
- breast pain,
- breast enlargement, and
- changes in sexuality (increase or decrease in libido).
- Abdominal pain may indicate the development of gallstones or occasionally hepatitis.
- Migraineheadaches have been associated with estrogen therapy.
- Estrogens can cause sodium and fluid retention leading to edema.
- Melasma, tan or brown patches, may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped.
- Conjugated estrogens may cause an increase in the curvature of the cornea. Patients with contact lenses may develop intolerance to their lenses.
- Blood clots are an occasional but serious adverse effect and are dose-related. (The higher the dose of Lindisc, the more likely blood clots are to form.) Cigarettesmokers are at a higher risk for clots, and, therefore, patients requiring estrogen therapy are strongly encouraged to quit smoking.
- Estrogens can increase the risk of endometrial cancer. This risk may be decreased if estrogens are combined with progestin.
- Some people also have a higher chance of developing breast cancer while taking estrogens. Sometimes people who have breast cancer when they are taking estrogens may have increased calcium in the blood. If this happens, the estrogen should be stopped.
Symptoms of an overdose include the following:
- Nausea or vomiting
- Heavy vaginal bleeding
- Tender breasts
- Discolored urine
If you suspect an overdose, you should contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Is Lindisc safe to take if I'm pregnant or breastfeeding?
Estrogens should not be used during pregnancy due to an increased risk of fetal abnormalities.
Estrogens are secreted in milk and cause unpredictable effects in the infant. Estrogens generally should not be used by women if they are breastfeeding.
A modern approach to HRT
Modern hormone replacement is body-identical topical Lindisc plus oral micronized progesterone.