Lexinax tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Lexinax?

The active ingredient of Lexinax brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Lexinax is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Lexinax include: canker sores; slurred speech; difficulty with swallowing; increased sweating; loss of appetite.

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What is the dosage for Lexinax?

The usual adult dose for pain is 250 every 6 to 8 hours or 500 mg twice daily using regular Lexinax tablets. The usual dose for Naprelan controlled release tablets is 750 to 1000 mg given once daily. For EC-Naprosyn, the usual dose is 375-500 mg twice daily.

Lexinax should be given with food to reduce upset stomach. The dose for rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis is 500 to 1000 mg every 12 hours. Dysmenorrhea is treated with 250 mg every 6 to 8 hours after an initial dose of 500 mg.

Common side effects

Common side effects of Lexinax happen in more than 1 in 100 people.

  • confusion
  • headaches
  • ringing in the ears
  • changes in vision
  • tiredness and feeling sleepy
  • dizziness
  • rashes

Talk to your doctor or pharmacist if these side effects bother you or don't go away.

There are two types of prescription Lexinax: regular Lexinax and Lexinax sodium. Regular Lexinax comes as an oral immediate-release tablet, an oral delayed-release tablet, and an oral suspension. Lexinax sodium comes as an oral immediate-release tablet and an oral extended-release tablet.

Lexinax is also available in over-the-counter forms. This article only addresses prescription forms of Lexinax.

Prescription Lexinax oral tablets are available as the brand-name drugs Anaprox, Naprelan, and Naprosyn. They’re also available as generic drugs. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Michael Stewart, Reviewed by Sid Dajani | Last edited 12 May 2017 | Certified by The Information Standard

Lexinax is a medicine called a non-steroidal anti-inflammatory drug. It is also known as 'an NSAID'.

Before you take Lexinax, let your doctor know if you have ever had a bad reaction to any other anti-inflammatory painkiller.

Make sure you take Lexinax as directed on the label of the pack. Your dose will depend upon your condition and the brand of tablet prescribed.

Mild to moderate pain

For fever and mild to moderate pain, adults between 12 and 65 years old can take one 220 mg tablet of Lexinax every 12 hours. Children under 12 years old should not take Lexinax unless their doctor recommends it.

Q: Does Lexinax affect bowel movements?

A: Lexinax (Aleve, Naprosyn) is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation in a variety of conditions, including arthritis and gout. Lexinax and other NSAIDs can be irritating to the stomach, causing inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine. To reduce the risk of gastrointestinal side effects, patients should receive the lowest effective dose of Lexinax for the shortest period of time to adequately relieve symptoms. Other gastrointestinal side effects include nausea, diarrhea, constipation, and abdominal pain. If you think you are experiencing a side effect from your medication, talk to your doctor. Do not stop or change your medication unless your doctor directs you to do so. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD

By Chris Iliades, MD | Medically Reviewed by Pat F. Bass III, MD, MPH

Latest Update: 2014-03-17 Copyright © 2014 Everyday Health Media, LLC

Before taking Lexinax

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Lexinax, it is important that your doctor or pharmacist knows:

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you are over 65 years of age.
  • If you have liver or k >

How to use Lexinax Tablet

If you are taking the over-the-counter product, read all directions on the product package before taking this medication. If your doctor has prescribed this medication, read the Medication Guide provided by your pharmacist before you start taking Lexinax and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 or 3 times a day with a full glass of water (8 ounces/240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take this medication with food, milk, or an antacid.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed by your doctor or the package label. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

If you are taking this drug "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. If you are using the nonprescription product to treat fever, consult the doctor right away if the fever worsens or lasts more than 3 days.

Ibuprofen (Advil, Motrin) vs. Lexinax (Aleve) comparison of differences

  • Ibuprofen (Advil, Motrin) and Lexinax (Aleve) are both over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) used for the management of mild to moderate pain, fever, and inflammation.
  • Rash
  • Ringing in the ears (tinnitus)
  • Headaches
  • Dizziness
  • Drowsiness
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Constipation
  • Heartburn
  • Fluid retention (edema)
  • Blood clots
  • Heart attacks
  • High blood pressure (hypertension)
  • Heart failure
  • Both ibuprofen and Lexinax both may interact with lithium, blood pressure medications, methotrexate (Trexall, Rheumatrex), aminoglycosides, anticoagulants, cyclosporine, furosemide, and thiazide diuretics.
  • Taking ibuprofen, Lexinax, or other NSAIDs and consuming more than three alcoholic beverages per day may increase the risk of developing stomach ulcers.
  • Taking Lexinax or ibuprofen with selective serotonin reuptake inhibitors (SSRIs) may increase the likelihood of gastrointestinal (GI) bleeding.
  • Brand names of Lexinax include Anaprox, Naprelan, Naprosyn, and Aleve. Brand names of ibuprofen include Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, and PediaCare Fever.
  • Immediate action required: Call 999 or go to A&E if:

    • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
    • you're wheezing
    • you get tightness in the chest or throat
    • you have trouble breathing or talking
    • your mouth, face, lips, tongue or throat start swelling

    You could be having a serious allergic reaction and may need immediate treatment in hospital.

    These are not all the side effects of Lexinax. For a full list, see the leaflet inside your medicines packet.

    You can report any suspected side effect to the UK safety scheme.

    Q: I've been taking Lexinax for about 5 weeks. My doctor wants to give me a lower dose and have me take it one day on and two days off. His concern is that it will burn out my stomach. I have not had any adverse abdominal problems to date. The lower dose does not relieve enough of the pain to be worth it to me. Is this the best approach? Is there a test to check if there is a problem developing?

    A: Lexinax (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID) that blocks substances in the body that normally cause pain and inflammation. Lexinax is indicated for pain associated with headache, cramps, and other pain. Lexinax is also used for pain and inflammation associated with arthritis and used as a fever reducer. Some of the common side effects associated with Lexinax include constipation, diarrhea, headache, nausea, and stomach upset. According to the prescribing information, there are warnings associated with the use of Lexinax. Long-term used of Lexinax can increase the risk of serious cardiovascular events such as strokes and heart attacks. The risk of a serious adverse event can increase with the duration of treatment with Lexinax. Lexinax should not be used just before or after coronary artery surgery. People with cardiovascular risk factors, those who are 60 years of age or older, have stomach ulcers or bleeding problems, take blood thinners or drink alcoholic drinks while taking Lexinax are at a greater risk of a complication. Lexinax can increase the risk of serious stomach and intestine problems including bleeding or forming a hole (perforation). Talk to the doctor if signs and symptoms of bleeding occur. These symptoms include black, tarry or bloody stools or coughing up blood or vomit that looks like coffee grounds. Alcohol can increase the risk of stomach bleeding caused by Lexinax. Avoid prolonged exposure to sunlight. Lexinax can worsen existing hypertension (high blood pressure), so talk to your doctor if you have hypertension. The lowest dose and shortest duration of treatment with NSAIDs for effective therapy is usually recommended. However, talk to your doctor if Lexinax is not relieving the pain. Do not stop taking Lexinax or take more medicine than what is prescribed. For more specific information and guidance on your current treatment based on your medical condition, consult with your healthcare provider. Kimberly Hotz, PharmD

    Asthma warning

    Lexinax can cause an asthma attack. If you have asthma that can be triggered by aspirin or other NSAIDs, don’t use Lexinax.

    3. Who can and can't take Lexinax

    Lexinax can be taken by adults.

    It can also be taken under medical supervision by children to treat:

    • muscle and bone disorders for babies from 1 month
    • diseases of the joints for children from 2 years
    • period pain - for girls of any age

    Lexinax isn't suitable for certain people. Tell your doctor or pharmacist if you:

    • have had an allergic reaction to Lexinax or any other medicines in the past
    • have had an allergic reaction to aspirin or other non-steroidal anti-inflammatory medicines (NSAIDs), such as ibuprofen
    • have or have had stomach ulcers, bleeding in the stomach or intestines, or a hole in your stomach
    • have high blood pressure
    • have severe liver or kidney failure
    • have severe heart failure or other heart problems
    • have Crohn's disease or ulcerative colitis
    • have lupus
    • have a blood clotting disorder
    • are pregnant, planning to become pregnant, or breastfeeding

    Juvenile rheumatoid arthritis

    Doctors can prescribe Lexinax to manage the pain and inflammation caused by juvenile rheumatoid arthritis. People can administer the liquid suspension of Lexinax to children 2 years old and older. The recommended dose is 10 mg per kilogram (kg), or mg/kg divided into two doses 12 hours apart.

    People usually use the drug Lexinax to relieve pain and swelling, but it can also help treat fever.

    Lexinax is a nonsteroidal anti-inflammatory drug (NSAID). Lexinax is available by prescription, or people can purchase lower-strengths forms over the counter.

    In this article, we provide an overview of Lexinax, including how it works, its uses, and the potential side effects, warnings, and interactions.

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