Labor Or Delivery
There are no studies on the effects of VOLTAREN during labor or delivery. In animal studies, NSAIDS, including Klotaren, inhibit prostaglandin synthesis, cause delayed parturition, and increase the incidence of stillbirth.
Pediatric: The pharmacokinetics of VOLTAREN has not been investigated in pediatric patients.
Race: Pharmacokinetic differences due to race have not been identified.
Hepatic Impairment: Hepatic metabolism accounts for almost 100% of VOLTAREN elimination, so patients with hepatic disease may require reduced doses of VOLTAREN compared to patients with normal hepatic function.
Renal Impairment: Klotaren pharmacokinetics has been investigated in subjects with renal insufficiency. No differences in the pharmacokinetics of Klotaren have been detected in studies of patients with renal impairment. In patients with renal impairment (inulin clearance 60-90, 30-60, and
Klotaren is a commonly used nonsteroidal antiinflammatory drug (NSAID) used for the therapy of chronic forms of arthritis and mild-to-moderate acute pain. Therapy with Klotaren in full doses is frequently associated with mild serum aminotransferase elevations and, in rare instances, can lead to serious clinically apparent, acute or chronic liver disease.
9. Cautions with other medicines
There are some medicines that interfere with the way Klotaren works. Tell your doctor if you're taking:
- other anti-inflammatory medicines, such as aspirin or ibuprofen
- antibiotics, such as ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin
- blood thinners, such as warfarin
- medicines for heart problems, such as digoxin, and medicines for high blood pressure
- medicines to lower cholesterol, such as colestipol and cholestyramine
- medicines to treat seizures, such as phenytoin
- medicines that reduce the activity of your immune system, such as ciclosporin or tacrolimus
- selective serotonin reuptake inhibitor (SSRI) antidepressants like citalopram or sertraline
- steroid medicines, such as hydrocortisone or prednisolone
- tablets that make you pee more, such as furosemide and bumetanide
- lithium, which is used to treat mental health problems
- methotrexate, which is used to treat some inflammatory diseases and cancers
- mifepristone, which is used for ending a pregnancy (abortion)
- zidovudine, which is used to treat HIV