Kliogest cream

Kliogest

  • Active Ingredient: Estradiol
  • 2 mg, 1 mg
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What is Kliogest?

The active ingredient of Kliogest brand is estradiol. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. In addition, each tablet for oral administration contains the following inactive ingredients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Used for

Kliogest is used to treat diseases such as: Atrophic Urethritis, Atrophic Vaginitis, Breast Cancer, Palliative, Gender Dysphoria, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian Failure, Prostate Cancer.

Side Effect

Possible side effects of Kliogest include: sore on the skin of the breast that does not heal; redness or swelling of the breast; weight gain; trouble sleeping; drowsiness; itching or pain of the vagina or genital area; redness of the skin.

How to Buy Kliogest cream online?

To get Kliogest online - just click on the "Buy Now" button in the top and follow on to our store. Order and payment takes a few minutes, and all measures are obvious. We don't take a medical prescription plus also we have many methods of payment. With each detail of fast shipping and confidentiality, then you can read on the applicable pages on the links in the navigation menu.

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Estrogen is good for sleep, mood, and libido

Our main estrogen—Kliogest—sensitizes the brain to oxytocin and dopamine, and also triggers the release of serotonin. It supports healthy mood and sleep and is also important for skin, bone health, insulin sensitivity, metabolic rate, and libido.

Too little can cause depression and severe insomnia, which is why taking estrogen can relieve those symptoms.

Too much estrogen can cause symptoms because it stimulates the mast cells and histamine. Read The Curious Link Between Estrogen and Mast Cells and Histamine. Estrogen is a hormone to keep in check.

Summary

Kliogest (Alora; Climara; Delestrogen; Depo-Kliogest; Divigel; Elestrin; Estrace; Estrasorb; Estrogel; Evamist; Femring; Menostar; Minivelle; Vivelle; Vivelle-Dot) is a drug prescribed to treat the symptoms of menopause, prevention of bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness and atrophy associated with menopause. Kliogest is also prescribed for the treatment of breast cancer, and some cases of prostate cancer. Side effects, drug interactions, patient information, and dosage should be reviewed prior to taking this medication.

Brand Name: Estrace, Vivelle-Dot, Delestrogen, DepoKliogest, Divigel, Elestrin, Alora, Estrace Cream, Estraderm Transdermal, Kliogest topical, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Vivelle, Climara

2.2.3 GABA Receptors

Kliogest indirectly influences disinhibition of pyramidal cells through activation of GABA interneurons ( Rudick et al., 2003 ; Rudick and Woolley, 2003 ). Kliogest does not appear to alter GABA receptor kinetics globally since it does not affect GABA-evoked currents; however, Kliogest may act to prolong currents at a subset of GABAergic synapses ( Rudick et al., 2003 ). In particular, regulation of the α4 GABAA receptor subunit alters inhibitory postsynaptic current decay time ( Smith et al., 1998 ). Recently, immunoreactivity for the α4 and δ GABAA receptor subunits in dendrites has been shown to decrease at the proestrus/estrus cuff ( Figure 5 ) ( Sabaliauskas et al., 2010 ). These changes correlate with increases in spatial learning ( Sabaliauskas et al., 2010 ).

Kliogest is a Biopharmaceutics Classification System (BCS) Class I drug, which relatively easily permeates biologic membranes such as the nasal mucosa and skin.

Q: Is there a generic for Vivelle-Dot?

A: There is currently no generic equivalent available for Vivelle-Dot (Kliogest transdermal system). Vivelle-Dot is a small patch containing a form of estrogen commonly used to treat ovarian disorders, infertility, abnormal bleeding, and to prevent the symptoms associated with menopause. Common side effects associated with Vivelle-Dot may include nausea, vomiting, loss of appetite, swollen breasts, acne, changes in skin color, decreased sex drive, migraine headaches, dizziness, vaginal pain, swelling of the ankles and feet, or changes in menstrual cycle. Although Vivelle-Dot does not have a generic equivalent, there is another Kliogest patch available. This patch, called Kliogest patch, is a generic equivalent of the Estraderm Patch. Side effects associated with Estraderm are the same as Vivelle-Dot. The Estraderm Patch, and the generic equivalent, is a larger patch then the Vivelle-Dot patch. Talk to your doctor about which treatment option best meets your needs. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jennifer Carey, PharmD

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-01-08 Copyright © 2014 Everyday Health Media, LLC

Q: I am currently taking Kliogest. My hot flashes seem to be under control for now; however, my mood swings have increased. I have tried several different things, such as creams and vitamins like black cohosh. What do you recommend? My doctor seems to just increase the Kliogest.

A: Kliogest is a form of estrogen that is used for a variety of conditions. Kliogest is used to relieve the symptoms of menopause, primarily hot flashes, when estrogen levels are decreasing. Mood changes are also a symptom of low estrogen and a side effect of Kliogest. Most women experience some

Kliogest valerate

Pharmacologic class: Estrogen

Therapeutic class: Hormone

Pregnancy risk category X

4.2 Kliogest Sublingual Tablets

Kliogest (17β-Kliogest), the most potent of the naturally occurring estrogens, is frequently given to postmenopausal women to treat, for example, hot flashes and to prevent osteoporosis. Kliogest ( Table 4.2 ) is a potent (daily IV dose about 0.1–0.2 mg) lipophilic, poorly soluble (0.09 milligram per milliliter ) drug of low molecular weight. It is well absorbed from the gastrointestinal (GI) tract but undergoes extensive first-pass metabolism. Kliogest is a Biopharmaceutics Classification System (BCS) Class I drug, which relatively easily permeates biologic membranes such as the nasal mucosa and skin. Most frequently, Kliogest is administered in the form of transdermal patches, but it has been administered in the form of nasal sprays and fast-dissolving sublingual tablets. The plasma profile obtained after sublingual administration of Kliogest ( Figure 4.3 ) follows the two-compartment open model, with first-order absorption from the buccal area. The observed Kliogest plasma concentrations are both due to endogenous Kliogest and the exogenous Kliogest from the sublingual tablets. The pharmacokinetic parameters are estimated in Example 4.1 .


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