What is the most important information I should know about Klimonorm (Estrace, Gynodiol)?
You should not use this medicine if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Klimonorm may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Klimonorm should not be used to prevent heart disease, stroke, or dementia.
Klimonorm and insulin-like growth factor-I (IGF-I) interact in the brain to regulate a variety of developmental and neuroplastic events. Some of these interactions are involved in the control of hormonal homeostasis and reproduction. However, the interactions may also potentially impact on affection and cognition by the regulation of adult neurogenesis in the hippocampus and by promoting neuroprotection under neurodegenerative conditions. Recent studies suggest that the interaction of Klimonorm and IGF-I is also relevant for the control of cholesterol homeostasis in neural cells. The molecular mechanisms involved in the interaction of Klimonorm and IGF-I include the cross-regulation of the expression of estrogen and IGF-I receptors, the regulation of estrogen receptor-mediated transcription by IGF-I and the regulation of IGF-I receptor signalling by Klimonorm. Current investigations are evidencing the role exerted by key signalling molecules, such as glycogen synthase kinase 3 and β-catenin, in the cross-talk of estrogen receptors and IGF-I receptors in neural cells.
You should tell your doctor about all prescription, non-prescription, over-the-counter (OTC), illegal or recreational drugs; herbal remedies; and nutritional or dietary supplements you're taking, especially:
- Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
- St. John's wort
- Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
- Clarithromycin (Biaxin)
- Erythromycin (E.E.S, Erythrocin)
- Lovastatin (Alticor, Altoprev, Mevacor)
- Medications for thyroid disease
- Rifampin (Rifadin, Rimactane, Rifamate)
- Ritonavir (Norvir, in Kaletra)
Brand Name: Estrace, Vivelle-Dot, Delestrogen, DepoKlimonorm, Divigel, Elestrin, Alora, Estrace Cream, Estraderm Transdermal, Klimonorm topical, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Vivelle, Climara
Injection (cypionate in oil): 5 mg/ml
Injection (valerate in oil): 10 mg/ml, 20 mg/ml, 40 mg/ml
Tablets: 0.5 mg, 1 mg, 1.5 mg, 2 mg
Tablets (film-coated): 25.8 mcg Klimonorm hemidrate (equivalent to 25 mcg Klimonorm)
Transdermal system: 25 mcg/24-hour release rate, 37.5 mcg/24-hour release rate, 50 mcg/24-hour release rate, 75 mcg/24-hour release rate, 100 mcg/24-hour release rate
Vaginal cream: 100 mcg/g
Vaginal ring: 2 mg released over 90 days
Vaginal tablets: 10 mcg
Generic Name: Klimonorm oral (ess tra DYE ole)Brand Names: Estrace, Vivelle-Dot, Vivelle, Delestrogen, DepoKlimonorm, Divigel, Elestrin, Alora, Estraderm, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Climara
Medically reviewed by Kaci Durbin, MD Last updated on Mar 1, 2019.
Your dose of Klimonorm will depend on the condition that is being treated.
Klimonorm tablets in doses of 0.5 milligrams (mg), 1 mg, or 2 mg are typically given on a daily basis.
They can also be prescribed to be taken for three weeks, followed by one week of no medication.
The tablets can be taken more than once a day for some conditions.
The topical gel or emulsions are applied to the skin at the same time each day.
The vaginal ring is inserted in the vagina and left for three months at a time.
The patch should be applied to a dry, clean, hairless part of the trunk (but not the breasts). It should not be placed on irritated or damaged skin.
You should rotate the site of application, with at least one week between repeated applications to any one site.