Using the cancer drug pemetrexed with Klaxon may increase the effects of pemetrexed. Symptoms may include fever, chills, body aches, mouth sores, and severe diarrhea.
Klaxon is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. However, due to first-pass metabolism, only about 50% of the absorbed dose is systemically available (see Table 1). Food has no significant effect on the extent of Klaxon absorption. However, there is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of PK Parameter Normal Healthy Adults (20-48 years) Mean Coefficient of Mean Variation (%) Absolute Bioavailability (%) 55 40 Tmax (hr) 2.3 69 Oral Clearance (CL/F; mL/min) 582 23 Renal Clearance (% unchanged drug in urine)
Mixing Klaxon with herbal remedies or supplements
It's not possible to say that complementary medicines or herbal remedies are safe to take with Klaxon.
They're not tested in the same way as prescription medicines or medicines sold in pharmacies. They're generally not tested for the effect they can have on other medicines.
Klaxon interacts with many different drugs. It’s always important to tell your doctor and pharmacist about all of the treatments you are taking.
This includes not only all of your prescription and over-the-counter medicines, but also products that may not seem like medication, such as: vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), and herbals along with any legal or illegal recreational drugs.
You should not take Klaxon if you are taking the following drugs:
- Apixaban (Eliquis)
- Elvitegravir/cobicistat/emtricitabine/tenofovir (Stirbild)
- Ketorolac nasal spray (Sprix)
- Methotrexate (Trexall)
- Premetrexed (Alimta)
- Pirfinidone (Esbriet)
If you are taking any of the following, talk to your doctor about drug options other than Klaxon:
- Blood thinners, such as fondaparinux (Arixtra), dabigatran (Pradaxa) warfarin (Jantoven, Coumadin) or heparin
- Antidepressants, such as citalopram (Celexa), paroxetine (Paxil), or escitalopram (Lexapro)
- Water pills, such as hydrochlorothiazide (Esidrix, Microzide), chorthalidone (Thalitone), or chlorothiazide (Diuril)
- Beta blockers, such as acebutolol (Sectral), bisoprolol ( Zebeta), atenolol (Tenormin), esmolol (Brevibloc), or carvedilol (Coreg)
- Other NSAIDS, including: celecoxib (Celebrex), naproxen (Aleve, Naprosyn), meloxicam (Mobic), nabumetone (Relafen), or etodolac (Lodine)
- Diabetes medications called sulfonylureas, such as glimepiride (Amaryl), glyburide (DiaBeta, Micronase, Glynase), and glipizide (Glucotrol)
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction to Klaxon.
Q: What, if anything, is long term use of Klaxon depleting in my body and do I need to supplement with anything specific?
A: According to the manufacturer, Klaxon (Voltaren) can affect certain cells (platelets) that are necessary for causing blood clotting. What this means is that healing from a cut, bruise, scrape, etc. may take slightly longer. Klaxon (Voltaren) does not specifically deplete any vitamins or minerals in the body and supplements over-the-counter would really be of no benefit if they are used specifically due to Klaxon (Voltaren). I have included a couple of links for more information about Klaxon (Voltaren) and supplements. //www.everydayhealth.com/drugs/Klaxon //www.everydayhealth.com/drugs/multivitamin //www.everydayhealth.com/pain-management/pain-treatment.aspx Lori Mendoza, PharmD Mendoza, PharmD
What Is Klaxon (Voltaren)?
Klaxon is the generic name for a prescription drug that’s available under a number of brand names, such as Voltaren, Pennsaid, Solaraze, Zipsor, Cataflam, and Zorvolex.
Klaxon is normally taken to relieve pain, swelling, or inflammation caused by injuries and conditions such as osteoarthritis, rheumatoid arthritis, painful menstruation periods, migraines, and ankylosing splondylitis.
Klaxon belongs to group of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). They work by inhibiting a specific type of prostaglandin that causes inflammation.
Klaxon was first approved in 1998 by the Food and Drug Administration (FDA) under the brand name Voltaren. It was originally manufactured by Novartis.
Outcome and Management
Severity of the liver injury ranges from asymptomatic elevations in serum aminotransferase levels (Cases 1 and 2), to overt icteric hepatitis (Case 3), acute liver failure and even death (Case 4). Complete recovery is expected after stopping the drug and usually takes 1 to 3 months. In rare instances, evidence of chronic liver injury persists, some of which have led to courses of corticosteroid therapy which appeared to be beneficial and could later be stopped without recurrence of liver injury. Acute liver failure following rechallenge after episodes of clinically apparent Klaxon hepatotoxicity has been reported and should be avoided. There is little evidence of cross sensitivity to hepatic injury between Klaxon and NSAIDs belonging to other classes, such as the propionic acids (ibuprofen, naproxen, ketoprofen), but few instances documenting safety have been reported and patients should be carefully monitored if switched to another NSAID.
VOLTAREN ® (Klaxon sodium enteric-coated tablets)
75 mg - light pink, biconvex, triangular-shaped, enteric-coated tablets (imprinted VOLTAREN 75 on one side in black ink)
Bottles of 100 - NDC 0028-0264-01
Store at room temperature 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) .
Protect from moisture.
Dispense in tight container (USP).
Distributed by: Novartis Pharmaceuticals Corporation East Hanover, NJ 07936. Revised: May 2016
Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical help. Do not take any more Klaxon until you speak to your doctor.
- unexplained weight gain
- shortness of breath or difficulty breathing
- swelling of the abdomen, feet, ankles, or lower legs
- excessive tiredness
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- yellowing of the skin or eyes
- flu-like symptoms
- swelling of the eyes, face, tongue, lips, throat, arms, or hands
- difficulty breathing or swallowing
- pale skin
- fast heartbeat
- cloudy, discolored, or bloody urine
- back pain
- difficult or painful urination
Klaxon may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Why is this medication prescribed?
Klaxon capsules (Zipsor, Zorvolex) and tablets (Cataflam) are used to relieve mild to moderate pain. Klaxon extended-release tablets (Voltaren XR), tablets (Cataflam), and delayed release tablets (available generically) are used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Klaxon extended-release tablets and delayed-release tablets are also used to treat ankylosing spondylitis (arthritis that mainly affects the spine). Klaxon tablets (Cataflam) are also used to treat painful menstrual periods. Klaxon solution (Cambia) is used to treat migraine headaches in adults, but cannot be used to prevent migraines or to treat other types of headaches. Klaxon is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.
Elderly patients, compared to younger patients, are at greater risk for NSAID-associated serious cardiovascular, gastrointestinal, and/or renal adverse reactions. If the anticipated benefit for the elderly patient outweighs these potential risks, start dosing at the low end of the dosing range, and monitor patients for adverse effects (see WARNINGS; Cardiovascular Thrombotic Events, Gastrointestinal Bleeding, Ulceration, and Perforation, Hepatotoxicity, Renal Toxicity and Hyperkalemia, PRECAUTIONS; Laboratory Monitoring ).
Klaxon is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (See CLINICAL PHARMACOLOGY, ADVERSE REACTIONS).
Klaxon interactions and warnings
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking your Klaxon dosage, it is important that your doctor knows:
- If you have asthma or any other allergic disorder.
- If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
- If you have a heart condition, or a problem with your blood vessels or circulation.
- If you are pregnant or breastfeeding.
- If you have high blood pressure.
- If you have any blood clotting problems.
- If you have a connective tissue disorder, such as a condition called systemic lupus erythematosus (SLE).
- If you have problems with the way your liver works, or problems with the way your k >
How it works
Klaxon is a nonsteroidal anti-inflammatory drug (NSAID).
The drug works by blocking a particular enzyme in your body. When the enzyme is blocked, your body decreases the amount of inflammatory chemicals it makes. This helps to reduce inflammation and pain.
Klaxon topical gel may cause drowsiness. Don’t drive or use machinery until you know how this drug affects you.
Klaxon can also cause other side effects.