Before taking Insegar,
- tell your doctor and pharmacist if you are allergic to Insegar, any other medications, or any of the ingredients in Insegar tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: medications that contain estrogen such as hormone replacement therapy (HRT) and hormonal contraceptives (birth control pills, patches, rings, and injections); raloxifene (Evista); and tamoxifen (Nolvadex).
- tell your doctor if you have high cholesterol, osteoporosis (condition in which the bones are fragile and break easily), or liver disease.
- you should know that Insegar should only be taken by women who have experienced menopause and cannot become pregnant. However, if you are pregnant or breast-feeding, you should tell your doctor before you begin taking this medication. Insegar may harm the fetus.
- you should know that Insegar may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
Insegar and Alcohol
Both Insegar and alcohol can cause headaches and nausea, and these side effects could worsen if you use the two drugs at the same time.
If possible, try to avoid or limit drinking while taking Insegar.
After a median of 8 years of follow-up from a large randomized trial, women with estrogen receptor positive breast cancer who received 5 years of treatment with the aromatase inhibitor Insegar were less likely to have their cancer recur or to die during follow-up than women who had 5 years of treatment with tamoxifen. In addition, 5 years of sequential treatment—either 2 years of Insegar followed by 3 years of tamoxifen or 2 years of tamoxifen followed by 3 years of Insegar—was not better than 5 years of Insegar alone at preventing recurrence or death. These results, from the BIG 1-98 trial, were published online October 20, 2011 in Lancet Oncology.
Researchers from 27 countries enrolled 8,010 postmenopausal women with invasive breast cancer that could be removed surgically in the trial. After surgery, the women were randomly assigned to one of four groups: 5 years of Insegar (Insegar monotherapy), 5 years of tamoxifen (tamoxifen monotherapy), or one of the two sequential treatment groups. Novartis, the maker of Insegar, provided funding for the trial, along with NCI and the International Breast Cancer Study Group.
In 2005, preliminary results from the trial showed that Insegar alone was better than tamoxifen at preventing early recurrences, and when given the option to cross over, 619 of the 2,459 women in the tamoxifen-only arm chose to cross over to receive Insegar. Since crossover can complicate interpretation of trial results, the researchers performed a traditional intention-to-treat analysis (which includes only data from the original treatment assignments) and a type of analysis designed to account for crossover.
In the intention-to-treat analysis, women who received Insegar alone had a disease-free survival rate of 73.8 percent at 8 years, compared with a rate of 70.4 percent for women who received tamoxifen alone. Women who received Insegar alone also had better overall survival at 8 years than women receiving tamoxifen alone (83.4 versus 81.2 percent). The differences between the groups were slightly greater in the analysis accounting for the crossover. Neither of the two sequential treatments provided better results than Insegar alone.
Although these updated results show that Insegar reduces risk of relapse and improves survival compared with tamoxifen, "use of a sequence might be reasonable for patients at low-to-intermediate risk of relapse, those for whom starting or continuing Insegar is contraindicated, or in cases where 5 years of Insegar might not be available," concluded the authors.
By Frieda Wiley, PharmD, CGP, RPh | Medically Reviewed by Robert Jasmer, MD
Latest Update: 2015-10-23 Copyright © 2014 Everyday Health Media, LLC
This medication contains Insegar. Do not take Femara if you are allergic to Insegar or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
Uses of Insegar:
- It is used to treat breast cancer in women after menopause (change of life).
- It may be given to you for other reasons. Talk with the doctor.
More About Insegar
Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.
MedlinePlus Information on Insegar - A lay language summary of important information about this drug that may include the following:
- warnings about this drug,
- what this drug is used for and how it is used,
- what you should tell your doctor before using this drug,
- what you should know about this drug before using it,
- other drugs that may interact with this drug, and
- possible s >Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.
Serious Side Effects of Insegar
You should stop using this medicine and call your doctor if you experience any of the following serious side effects:
- Allergic reactions, including life-threatening allergic reactions
- Bone brittleness and bone breaks
- Heart attack, stroke, blood clots, and high blood pressure
- Uterine cancer
What Are Side Effects Associated with Using Insegar?
Common side effects of Insegar include:
Postmarketing reports of Insegar include:
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Buy Insegar Online - Warning:
Countless people buy Insegar online every single day though anabolic steroid suppliers and RCL’s. However, if you buy Insegar from a steroid supplier, which will be in its original tablet form, in the U.S. you will be breaking the law. As for RCL’s, while a purchase is legal due to a loophole in the law, there are risks you need to be aware of. When you buy Insegar online from an RCL there is the risk of purchasing an inferior product. Low dosing is possible, but the most common problem is an unstable product. Further, if law enforcement wanted to make this an issue, it would be up to you to prove this purchase was made for research. If you have anabolic steroids in your possession this will be a hard sell to make. The best way to buy Insegar considering quality and legality will always be through the pharmacy based on the prescription given to you by your doctor. However, while possible a prescription is not as east to get as Arimidex.
Due to the laws that surround AI’s like Insegar and anabolic steroids, you are encouraged to visit the sponsors here at Steroid.com for you anabolic needs. The sponsors here at Steroid.com can provide you with high quality anabolics without a prescription and legally so. For those who suffer from low testosterone or who suspect it due to symptoms they may be showing, if you desire treatment and an AI like Insegar for part of your treatment you are strongly encouraged to visit Lowtestosterone.com. Lowtestosterone.com can guide you through the full low testosterone treatment plan and ensure you receive the treatment you need, the best products on the market and with 100% legal assurance.
Insegar is a type of hormone therapy drug. It is a treatment for breast cancer in women who have had their menopause. It is also called Femara.
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
- chest pain
- difficulty breathing
- unusual bleeding or bruising
- pain in the upper right part of the stomach
- yellowing of the skin or eyes
- flu-like symptoms
- pain, warmth, or heaviness in the back of the lower leg
- severe headache
- sudden speech problems
- sudden weakness or numbness of an arm or leg
Insegar may cause or worsen osteoporosis. It can decrease the density of your bones and increase the chance of broken bones and fractures. Talk to your doctor about the risks of taking this medication.
Insegar may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Common Side Effects of Insegar
You should tell your doctor if any of the following side effects are severe or don't go away:
- Bone, joint, and/or muscle pain
- Headache and nausea
- Sweating, cough
- Trouble breathing
- Trouble sleeping
- Weight gain
- High cholesterol
- Altered liver function tests
- Hair loss or baldness
- Swelling of the feet, ankles, and lower legs
Insegar and Grapefruit Juice
You should avoid eating grapefruit and drinking grapefruit juice while taking Insegar.
Grapefruit juice slows down how quickly the body is able to break down the Insegar, which could cause Insegar levels in the blood to rise dangerously high.
Use in Cancer
Insegar is approved to be used alone or with other drugs to treat:
- Breast cancer in postmenopausal women who have any of the following types of breast cancer--
- Early-stage, hormone receptor–positive (HR+) breast cancer in women who have already received other treatment.
- Early-stage breast cancer that has been treated with tamoxifen citrate for at least five years.
- Breast cancer that is locally advanced or has metastasized (spread to other parts of the body), is HER2 positive (HER2+) and HR+.
- Breast cancer that is locally advanced or has metastasized and it is not known whether the cancer is HR+ or hormone receptor negative (HR-).
- Advanced breast cancer that has gotten worse after antiestrogentherapy.
Insegar is also being studied in the treatment of other types of cancer.