Estracomb tablets


  • Active Ingredient: Estradiol
  • 2 mg, 1 mg
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What is Estracomb?

The active ingredient of Estracomb brand is estradiol. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. In addition, each tablet for oral administration contains the following inactive ingredients: Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Used for

Estracomb is used to treat diseases such as: Atrophic Urethritis, Atrophic Vaginitis, Breast Cancer, Palliative, Gender Dysphoria, Hypoestrogenism, Oophorectomy, Osteoporosis, Postmenopausal Symptoms, Primary Ovarian Failure, Prostate Cancer.

Side Effect

Possible side effects of Estracomb include: drowsiness; swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs; weight gain; chills; redness of the skin.

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Estracomb and Weight Gain

Water retention that increases your weight is a common side effect.

Talk to your doctor about adjusting your dose of Estracomb if weight gain becomes a problem.

Estrogen may not be a breast cancer risk

Breast cancer risk is determined by insulin, thyroid, inflammation, vitamin D, iodine deficiency, toxic chemical exposure, and so much more. It may not cause breast cancer and at least one study has found that supplemental Estracomb slows the growth of advanced breast cancer.


Estracomb (Alora; Climara; Delestrogen; Depo-Estracomb; Divigel; Elestrin; Estrace; Estrasorb; Estrogel; Evamist; Femring; Menostar; Minivelle; Vivelle; Vivelle-Dot) is a drug prescribed to treat the symptoms of menopause, prevention of bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness and atrophy associated with menopause. Estracomb is also prescribed for the treatment of breast cancer, and some cases of prostate cancer. Side effects, drug interactions, patient information, and dosage should be reviewed prior to taking this medication.

Is Estracomb safe to take if I'm pregnant or breastfeeding?

Estrogens should not be used during pregnancy due to an increased risk of fetal abnormalities.

Estrogens are secreted in milk and cause unpredictable effects in the infant. Estrogens generally should not be used by women if they are breastfeeding.

Estracomb Dosage

Your dose of Estracomb will depend on the condition that is being treated.

Estracomb tablets in doses of 0.5 milligrams (mg), 1 mg, or 2 mg are typically given on a daily basis.

They can also be prescribed to be taken for three weeks, followed by one week of no medication.

The tablets can be taken more than once a day for some conditions.

The topical gel or emulsions are applied to the skin at the same time each day.

The vaginal ring is inserted in the vagina and left for three months at a time.

The patch should be applied to a dry, clean, hairless part of the trunk (but not the breasts). It should not be placed on irritated or damaged skin.

You should rotate the site of application, with at least one week between repeated applications to any one site.

Tell your doctor if you have any of the following: high blood pressure, angina, or heart disease; high levels of cholesterol or triglycerides in your blood; liver disease; kidney disease; asthma; epilepsy; migraines; diabetes; depression; gallbladder disease; uterine fibroids; had a hysterectomy (uterus removed); a narrow, short, or prolapsed vagina; vaginal irritation; or a vaginal infection.

Do not use Estracomb without first talking to your doctor if you have a circulation, bleeding, or blood-clotting disorder; undiagnosed, abnormal vaginal bleeding; or any type of breast, uterine, or hormone-dependent cancer. Using Estracomb may be dangerous in some cases if you have any of the conditions listed above.

You may not be able to use Estracomb, or you may require a dosage adjustment or special monitoring during treatment, if you have any of the conditions listed above.

Long-term treatment with Estracomb may increase the risk of a stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Estracomb during a long-term cycle. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.

The Women’s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate.

The WHIMS study found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy.

Estracomb is in the FDA pregnancy category X. This means that Estracomb will cause birth defects in an unborn baby. Do not use Estracomb if you are pregnant or are planning a pregnancy.

Estracomb may decrease milk flow and have other effects on milk composition. Do not use Estracomb without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Insert the next dose of cream or ring as soon as you remember. Continue to follow your regular schedule. Do not use two doses simultaneously unless your doctor directs otherwise.

If at any time the ring falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to reinsert it.

What side effects can this medication cause?


Estracomb is a female sex hormone necessary for many processes in the body. Estracomb vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall.

This medication is also prescribed for symptomatic treatment of the usual symptoms associated with menopause (hot flushes, vaginal dryness, etc.), prevention of bone fractures associated with osteoporosis, reduction of the risk of heart attacks and strokes, and dysfunctional (excessive and painful) uterine bleeding.

The vaginal cream is prescribed for vaginal or vulvar atrophy associated with menopause.

What is the most important information I should know about Estracomb (Estrace, Gynodiol)?

You should not use this medicine if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use if you are pregnant.

Estracomb may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estracomb should not be used to prevent heart disease, stroke, or dementia.

Estracomb valerate

Pharmacologic class: Estrogen

Therapeutic class: Hormone

Pregnancy risk category X

Indications and dosages

➣ Symptoms of menopause, atrophic vaginitis, female hypogonadism, ovarian failure, and osteoporosis

Adults: 0.5 to 2 mg (Estracomb) P.O. daily continuously or cyclically. Or 1 to 5 mg (cypionate) or 10 to 20 mg (valerate) I.M. monthly. Or 50- or 100-mcg/24-hour transdermal patch applied twice weekly (Alora, Estraderm) or weekly (Climara). Or 25-mcg/24-hour patch applied q 7 days (FemPatch) or 37.5- to 100-mcg transdermal patch applied twice weekly (Vivelle). Or 2 to 4 g (0.2 to 0.4 mg) vaginal cream (Estracomb) applied daily for 1 to 2 weeks, then decreased to 1 to 2 g/day for 1 to 2 weeks, then a maintenance dose of 1 g one to three times weekly for 3 weeks, then off for 1 week; repeat cycle once vaginal mucosa has been restored. Or 2-mg vaginal ring q 3 months or 10-mcg vaginal tablet once daily for 2 weeks, then twice weekly.

➣ Postmenopausal breast cancer

Adults: 10 mg P.O. t.i.d. (Estracomb)

Adults: 1 to 2 mg P.O. t.i.d. (Estracomb) or 30 mg I.M. q 1 to 2 weeks (valerate)

Estracomb side effects

Get emergency medical help if you have signs of an allergic reaction to Estracomb: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;

swelling or tenderness in your stomach;

jaundice (yellowing of the skin or eyes);

memory problems, confusion, unusual behavior;

unusual vaginal bleeding, pelvic pain;

a lump in your breast; or

nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common Estracomb side effects may include:

nausea, vomiting, diarrhea, stomach cramps;

mood changes, sleep problems (insomnia);

cold symptoms such as stuffy nose, sinus pain, sore throat;

darkening of the skin or skin rash;

thinning scalp hair; or

vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

An Estracomb test is a simple blood test to measure the amount of Estracomb in a person's blood. Estracomb, also known as E2, is one of the four types of estrogen that the ovaries chiefly produce. The adrenal glands, placenta, testes, and some tissues also produce smaller amounts of this hormone.

The right estrogen levels are essential for reproductive health. Having too much or too little estrogen can also lead to medical problems, such as weak bones, urinary tract infections, and even depression.

Doctors may order an Estracomb test if they are concerned about a person's fertility, puberty, or menopause. In this article, we examine when a doctor might order this test, what the results can mean, and what to expect during and after the test.

Estrogen is good for sleep, mood, and libido

Our main estrogen—Estracomb—sensitizes the brain to oxytocin and dopamine, and also triggers the release of serotonin. It supports healthy mood and sleep and is also important for skin, bone health, insulin sensitivity, metabolic rate, and libido.

Too little can cause depression and severe insomnia, which is why taking estrogen can relieve those symptoms.

Too much estrogen can cause symptoms because it stimulates the mast cells and histamine. Read The Curious Link Between Estrogen and Mast Cells and Histamine. Estrogen is a hormone to keep in check.

Brand Name: Estrace, Vivelle-Dot, Delestrogen, DepoEstracomb, Divigel, Elestrin, Alora, Estrace Cream, Estraderm Transdermal, Estracomb topical, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Vivelle, Climara

Estracomb is a female sex hormone necessary for many processes in the body. Estracomb vaginal products release estrogen that is absorbed directly through the skin of the vaginal wall.

Estracomb and Grapefruit

Grapefruit and grapefruit juice may interact with Estracomb and cause unwanted side effects.

You should talk to your doctor before consuming any grapefruit products while taking Estracomb.

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