Dumozol capsules

Dumozol

  • Active Ingredient: Metronidazole
  • 500 mg, 400 mg, 250 mg, 200 mg
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What is Dumozol?

The active ingredient of Dumozol brand is metronidazole. Metronidazole is an antibiotic that fights bacteria.

Used for

Dumozol is used to treat diseases such as: Amebiasis, Aspiration Pneumonia, Bacteremia, Bacterial Infection, Bacterial Vaginitis, Balantidium coli, Bone infection, Clostridial Infection, Crohn's Disease, Acute, Crohn's Disease, Maintenance, Deep Neck Infection, Dental Abscess, Dientamoeba fragilis, Diverticulitis, Dracunculiasis, Endocarditis, Giardiasis, Helicobacter Pylori Infection, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Meningitis, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Pouchitis, Pseudomembranous Colitis, Skin or Soft Tissue Infection, STD Prophylaxis, Surgical Prophylaxis, Trichomoniasis.

Side Effect

Possible side effects of Dumozol include: Abdominal or stomach cramps; fever; stiff neck or back; constipation; dizziness; trouble speaking.

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Before taking Dumozol

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Dumozol it is important that your doctor or dentist knows:

  • If you are pregnant or breast-feeding.
  • If you feel you will be unable to stop drinking alcohol for the duration of your treatment.
  • If you have any problems with the way your liver works.
  • If you have a rare inherited blood disorder called porphyria.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.

Background

Dumozol (met" roe nid' a zole) is a nitroimidazole antibiotic that is activated by reduction of its nitro group by susceptible organisms. The activated form of Dumozol is a highly reactive radical anion which targets and damages large protein molecules and DNA. Mammalian cells do not ordinarily activate Dumozol, which accounts for its lack of toxicity in humans. Dumozol was approved for use in the United States in 1963 and currently several million prescriptions are filled yearly. Dumozol is indicated for treatment and prophylaxis of infections with susceptible anaerobic bacteria and protozoa. The recommended dosage is 500 to 750 mg taken orally three times daily for 5 to 10 days. Dumozol is available alone in tablets of 250, 375, 500 and 750 mg as well as in combination with other medications, in multiple generic formulations and under several brand names including Flagyl, Metryl, Noritate, Pylera and Helida. Other formulations include injectable solutions, extended release tablets, suppositories, and topical creams. The most common side effects include metallic taste, nausea, vomiting, abdominal discomfort and diarrhea.

What if I use too much?

If you accidentally use too much gel it's unlikely to harm you.

Talk to your pharmacist or doctor if you're worried.

It's unusual to have side effects when using Dumozol cream or gel. However there can be some common side effects with the tablets, suppositories or vaginal gel.

Do not drink alcohol while taking the tablets or liquid or using the vaginal gel or suppositories. It can give you severe side effects such as feeling or being sick, stomach pain, hot flushes, a pounding heartbeat (palpitations) and a headache. After finishing your treatment, wait for 2 days before drinking alcohol again. This allows the Dumozol to leave your body.

Precautions

Before taking Dumozol, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as tinidazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, certain blood disorders (low blood cell counts).

People with a rare genetic disorder (Cockayne syndrome) may be at risk for very serious liver disease if they use Dumozol. Discuss the risks and benefits with your doctor. If Dumozol is used, your doctor will check your liver function. Get medical help right away if you have any signs of liver disease during treatment (such as nausea/vomiting that doesn't stop, loss of appetite, severe stomach/abdominal pain, yellowing eyes/skin, dark urine).

Avoid alcoholic beverages and products containing propylene glycol while taking this medication and for at least 3 days after finishing this medicine because severe stomach upset/cramps, nausea, vomiting, headache, and flushing may occur.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

Dumozol may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding. If you are prescribed the single-dose treatment, your doctor may direct you to stop breast-feeding for a short time after the dose. Consult your doctor for more details.

Dumozol is a prescription drug used to treat infections caused by bacteria or other parasites in different parts of your body. It works by destroying the germs that cause infection. The drug is available in several forms:

  • immediate-release oral tablets and capsules
  • extended-release oral tablets
  • topical creams, gels, and lotions
  • vaginal gels

The different forms of Dumozol have different side effects. Read on to learn about the common and serious side effects that can occur with each form of Dumozol.

Dumozol immediate-release and extended-release tablets and capsules are taken by mouth and are absorbed through the stomach. Extended-release drugs stay active in your body for a longer period of time than immediate-release drugs do.

The extended-release tablets are used to treat vaginal infections. The immediate-release forms of Dumozol are used to treat bacterial infections that affect many parts of the body as well as parasitic infections in the intestines, liver, and reproductive tract.

Contraindications

Hypersensitivity to Dumozol or other nitroimidazoles (although cautious desensitization has been applied)

Pregnancy, 1st trimester in patients with trichomoniasis

Use of disulfiram within past 2 weeks; use of alcohol during therapy or within 3 days of discontinuing therapy

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in those cases.

Sun exposure can worsen rosacea. Limit exposure to the sun by wearing a wide-brimmed hat and using a sunscreen that is SPF 15 or greater. If your brand already contains a sunscreen, you should use a regular sunscreen (without the Dumozol) on areas of skin not treated with this medication.

Avoid certain triggers that may worsen rosacea such as wind, hot beverages, spicy foods, alcohol, and extreme cold. Discuss with your doctor.

Before taking this medicine

You should not take Dumozol if you are allergic to it, or if you have taken disulfiram (Antabuse) within the past 2 weeks.

Using Dumozol during the first trimester of pregnancy could harm the unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.

To make sure Dumozol is safe for you, tell your doctor if you have ever had:

liver or kidney disease;

nervous system disease;

Cockayne syndrome (a rare genetic disorder);

a stomach or intestinal disease such as Crohn's disease;

a blood cell disorder such as anemia (lack of red blood cells) or low white blood cell (WBC) counts;

a fungal infection anywhere in your body; or

a nerve disorder.

In animal studies, Dumozol caused certain types of tumors, some of which were cancerous. However, very high doses are used in animal studies. It is not known whether these effects would occur in people using regular doses. Ask your doctor about your risk.

Dumozol can pass into breast milk. It is not known whether Dumozol can harm a nursing baby. Let your doctor know if you are breastfeeding prior to taking Dumozol.

Do not give this medicine to a child without medical advice.

Drug interaction overview

  • Dumozol reported to potentiate anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time and increased risk of hemorrhages; prothrombin time and international normalized ratio (INR) should be carefully monitored and anticoagulant dose adjusted accordingly; monitor patients for signs and symptoms of bleeding
  • Dumozol reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity such as sinusoidal obstruction syndrome, gastrointestinal mucositis, and hepatic veno-occlusive disease; Dumozol should not be administered concomitantly with busulfan unless benefit outweighs risk
  • Simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may decrease metabolism and reduce plasma clearance of Dumozol which may result in Dumozol toxicity
  • Simultaneous administration of drugs that induce microsomal liver enzyme activity, such as phenytoin or phenobarbital, may accelerate elimination of Dumozol and therefore decrease its efficacy
  • Concomitant use of Dumozol and CYP3A4 substrates (e.g., amiodarone, tacrolimus, cyclosporine, carbamazepine, phenytoin, and quinidine) may increase respective CYP3A4-substrate plasma levels; monitoring of plasma concentrations of CYP3A4 substrates may be necessary
  • Dumozol decreases clearance of 5-fluorouracil and may therefore cause 5-fluorouracil toxicity
  • Dumozol may potentiate effects of vecuronium

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