Dolostop tablets

Dolostop

  • Active Ingredient: Diclofenac
  • 100 mg
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What is Dolostop?

The active ingredient of Dolostop brand is diclofenac. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. The inactive ingredients in Diclofenac sodium delayed-release tablets include: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium starch glycolate, talc, titanium dioxide, triethyl citrate.

Used for

Dolostop is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Frozen Shoulder, Migraine, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica, Spondyloarthritis.

Side Effect

Possible side effects of Dolostop include: loss of appetite; weight loss; rapid weight gain; increased bleeding time; cloudy urine; swelling; constipation.

How to Buy Dolostop gel online?

To get Dolostop online - simply click on the "Buy Now" button in the top and follow on to our shop. Order and payment takes a few minutes, and all measures are evident. We do not take a medical prescription and also we have many methods of payment. With each detail of fast shipping and confidentiality, you can read on the relevant pages on the links in the navigation menu.

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Rated Dolostop for Osteoarthritis Report

I started taking 75mg in late January for horrible knee pain. This drug works great for pain. Within days I no longer hurt and really didn’t think I had a knee problem anymore. I was bone on bone knees and told I needed surgery. I took this drug twice a day and no problems at all until first if March. Started having eye problems and cornea abrasions appeared on both eyes and there had been no injuries of any kind. After weeks of eye treatments the eyes were not healing, I was referred to a cornea specialist. He told me to stop the drug that day, I did and two days later was healing finally. We have determined that if someone already has eye issues like dry severe dry eyes, etc. this drug could cause the abrasions. For me it did and now I’m afraid to take any NSAID of any kind. I know several friends who have taken this drug and have had no problems. I was one in a million but this problem does need to be documented. My doctor said it’s rare but he had several people with the same problem as I.

Dolostop gel

  • Gently squeeze out the tube - or press firmly and evenly on the nozzle of the dispenser - to get a small amount of gel.
  • Put the gel on the painful or swollen area and slowly rub it in. It may feel cool on your skin. Wash your hands afterwards.

You'll usually use the gel 2 to 4 times a day, depending on how strong it is. Check the packaging for more information or speak to your pharmacist.

If you're using the gel twice a day, use it once in the morning and once in the evening. If you're using it 3 or 4 times a day, wait at least 4 hours before putting on any more.

Use of NSAIDs, including VOLTAREN, during the third trimester of pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Avoid use of NSAIDs, including VOLTAREN, in pregnant women starting at 30 weeks of gestation (third trimester) (see WARNINGS; Premature Closure Of Fetal Ductus Arterious).

There are no adequate and well-controlled studies of VOLTAREN in pregnant women. Data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive. In the general U.S. population, all clinically recognized pregnancies, regardless of drug exposure, have a background rate of 2-4% for major malformations, and 15-20% for pregnancy loss. In animal reproduction studies, no evidence of teratogenicity was observed in mice, rats, or rabbits given Dolostop during the period of organogenesis at doses up to approximately 0.5, 0.5, and 1 times, respectively, the maximum recommended human dose (MRHD) of VOLTAREN, 200 mg/day, despite the presence of maternal and fetal toxicity at these doses . Based on animal data, prostaglandins have been shown to have an important role in endometrial vascular permeability, blastocyst implantation, and decidualization. In animal studies, administration of prostaglandin synthesis inhibitors such as Dolostop, resulted in increased pre- and post-implantation loss.

Reproductive and developmental studies in animals demonstrated that Dolostop sodium administration during organogenesis did not produce teratogenicity despite the induction of maternal toxicity and fetal toxicity in mice at oral doses up to 20 mg/kg/day (approximately 0.5 times the maximum recommended human dose of VOLTAREN, 200 mg/day, based on body surface area (BSA) comparison), and in rats and rabbits at oral doses up to 10 mg/kg/day (approximately 0.5 and 1 times, respectively, the MRHD based on BSA comparison). In a study in which pregnant rats were orally administered 2 or 4 mg/kg Dolostop (0.1 and 0.2 times the MRHD based on BSA) from Gestation Day 15 through Lactation Day 21, significant maternal toxicity (peritonitis, mortality) was noted. These maternally toxic doses were associated with dystocia, prolonged gestation, reduced fetal weights and growth, and reduced fetal survival. Dolostop has been shown to cross the placental barrier in mice, rats, and humans.

Blood pressure drugs

Dolostop may decrease the blood pressure-lowering effects of some drugs used to control blood pressure. Using Dolostop with certain blood pressure medications may also increase your risk of kidney damage.

Examples of these blood pressure drugs include:

  • angiotensin-converting enzyme (ACE) inhibitors, such as benazepril, captopril, enalapril, and lisinopril
  • angiotensin II receptor blockers, such as candesartan, irbesartan, losartan, and olmesartan
  • beta blockers, such as acebutolol, atenolol, metoprolol, and propranolol
  • diuretics (water pills) such as furosemide or hydrochlorothiazide

Q: What are the side effects of Dolostop?

A: The most commonly reported side effects of Dolostop (Cataflam, Voltaren-XR) are dyspepsia, nausea, abdominal pain, constipation, headache, dizziness, rash, and drowsiness. More serious (and rarer) reactions include stroke, high blood pressure, GI bleed, and heart attack. However, I have seen this drug used frequently without any problems.

What should I do if I forget a dose?

The powder for solution is usually taken as needed for migraine headaches. If you are taking any other Dolostop product and you forget to take a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

1. About Dolostop

Dolostop is a medicine that reduces inflammation and pain.

It's used to treat aches and pains, as well as problems with joints, muscles and bones. These include:

Dolostop comes as tablets, capsules and suppositories. These are available on prescription only.

It can also be given as an injection or as eyedrops. These are usually only given in hospital.

Dolostop gel and plasters for joint pain are available to buy from pharmacies.

Important

Do not use Dolostop gel more than 4 times in any 24-hour period.

The amount of gel you need will vary. It depends on the size of the area you want to treat. You'll usually use an amount about the size of a 1 penny or 2 pence piece (2 to 4 grams).

Common side effects

Common side effects of Dolostop tablets, capsules and suppositories happen in more than 1 in 100 people.

Talk to your doctor or pharmacist if these side effects bother you or don't go away:

  • headaches
  • feeling dizzy or vertigo
  • stomach ache, wind or loss of appetite
  • feeling sick (nausea)
  • being sick (vomiting) or diarrhoea
  • mild rash

You're less likely to have side effects with Dolostop gel or plasters. This is because not as much of the medicine gets into your body. But you may still get the same side effects, especially if you use a lot on a large area of skin.

In addition, using Dolostop gel or plasters can affect your skin. It can make your skin:

  • more sensitive to sunlight than normal
  • develop a rash where the gel or plaster has been applied
  • dry or irritated (eczema)
  • itchy or inflamed (dermatitis)

General

VOLTAREN ® (Dolostop sodium enteric-coated tablets) cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids and the patient should be observed closely for any evidence of adverse effects, including adrenal insufficiency and exacerbation of symptoms of arthritis. The pharmacological activity of VOLTAREN in reducing fever and inflammation may diminish the utility of these diagnostic signs in detecting complications of presumed noninfectious, painful conditions.

Contraindications

  • Absolute: Hypersensitivity to Dolostop, history of aspirin triad, treatment of perioperative pain associated with CABG; active gastrointestinal bleeding
  • IV: Moderate-to severe renal insufficiency in the perioperative period and patients who are at risk for volume depletion
  • Zipsor capsules are contraindicated in patients with history of hypersensitivity to bovineprotein

Effects of Drug Abuse

  • Agent is potent diuretic that, if given in excessive amounts, may lead to profound diuresis with water and electrolyte depletion

  • Increase in transaminase levels reported within 2 months of therapy; may occur at any time; monitor transaminase levels periodically beginning 4-8 weeks after initiation of therapy
  • See "What Are Side Effects Associated with Using Dolostop?"

  • Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include elderly individuals, those with impaired renal function, hypovolemia, heart failure, liverdysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers
  • See "What Are Side Effects Associated with Using Dolostop?"

  • Use caution in patients with bronchospasm, cardiac disease, CHF, hepaticporphyria, hypertension, fluid retention, severe renal impairment, smoking, systemic lupus erythematosus
  • Platelet aggregation and adhesion may be decreased; may prolong bleeding time
  • Use caution in blood dyscrasias or bone marrowdepression; also with thrombocytopenia, agranulocytosis, and aplastic anemia
  • Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include elderly individuals, those with impaired renal function, hypovolemia, heart failure, liver dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers
  • Therapy may increase risk of hyperkalemia, especially in renal disease, diabetics, the elderly, and concomitant use of agents that may induce hyperkalemia; monitor potassium closely
  • May cause dizziness blurred vision and neurologic effects that may impair physical and mental abilities
  • Risk of serious skin reactions, including Stevens Johnson syndrome and necrotizing enterocolitis
  • Persistent urinary symptoms, including bladder pain and dysuria, hematuria or cystitis may occur after initiating therapy; discontinue therapy with symptomonset and evaluate cause
  • Increase in transaminase levels reported within 2 months of therapy; may occur at any time; monitor transaminase levels periodically beginning 4-8 weeks after initiation of therapy
  • May increase risk of asepticmeningitis (rare), especially in patients with systemiclupus erythematous, and mixed connective tissue disorders
  • Use caution if patient dehydrated before initiating therapy; rehydrate patient before initiating therapy and monitor renal function closely
  • Injectable dosage form not recommended for long-term use
  • Different formulations not bioequivalent even if milligram strength the same; do not interchange products
  • Withhold for at least 4-6 half-lives prior to surgical or dental procedures
  • NSAIDs have the potential to trigger HF by prostaglandin inhibition that leads to sodium and water retention, increased systemic vascularresistance, and blunted response to diuretics
  • NSAIDs should be avoided or withdrawn whenever possible
  • AHA/ACC Heart Failure Guidelines; Circulation. 2016;134


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