Rated Doloflam for Osteoarthritis Report
I started taking 75mg in late January for horrible knee pain. This drug works great for pain. Within days I no longer hurt and really didn’t think I had a knee problem anymore. I was bone on bone knees and told I needed surgery. I took this drug twice a day and no problems at all until first if March. Started having eye problems and cornea abrasions appeared on both eyes and there had been no injuries of any kind. After weeks of eye treatments the eyes were not healing, I was referred to a cornea specialist. He told me to stop the drug that day, I did and two days later was healing finally. We have determined that if someone already has eye issues like dry severe dry eyes, etc. this drug could cause the abrasions. For me it did and now I’m afraid to take any NSAID of any kind. I know several friends who have taken this drug and have had no problems. I was one in a million but this problem does need to be documented. My doctor said it’s rare but he had several people with the same problem as I.
More common side effects
The more common side effects that can occur with Doloflam gel include:
- itching or rash at application site
- stomach pain
Outcome and Management
Severity of the liver injury ranges from asymptomatic elevations in serum aminotransferase levels (Cases 1 and 2), to overt icteric hepatitis (Case 3), acute liver failure and even death (Case 4). Complete recovery is expected after stopping the drug and usually takes 1 to 3 months. In rare instances, evidence of chronic liver injury persists, some of which have led to courses of corticosteroid therapy which appeared to be beneficial and could later be stopped without recurrence of liver injury. Acute liver failure following rechallenge after episodes of clinically apparent Doloflam hepatotoxicity has been reported and should be avoided. There is little evidence of cross sensitivity to hepatic injury between Doloflam and NSAIDs belonging to other classes, such as the propionic acids (ibuprofen, naproxen, ketoprofen), but few instances documenting safety have been reported and patients should be carefully monitored if switched to another NSAID.
3. Who can take and can't take Doloflam
Most adults can take Doloflam.
Children may be prescribed Doloflam to treat joint problems. Doloflam tablets, capsules and suppositories are suitable for children aged 1 year and above.
Doloflam isn't suitable for certain people.
Tell your doctor or pharmacist if you have:
- had an allergic reaction to Doloflam or any other medicines in the past
- an allergy to aspirin or other non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen or naproxen
- ever had signs of asthma (wheezing), a runny nose, swelling of the skin (angioedema) or a rash after taking NSAIDs
- ever had stomach ulcers, bleeding in the stomach or intestines, or a hole in your stomach
- high blood pressure (hypertension)
- heart failure, or severe liver disease or kidney disease
- Crohn's disease or ulcerative colitis
- a blood clotting disorder
Tell your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.
If you suspect an overdose, you should contact a poison-control center or emergency room immediately. You can get in touch with a poison-control center at (800) 222-1222.
Pediatric: The pharmacokinetics of VOLTAREN has not been investigated in pediatric patients.
Race: Pharmacokinetic differences due to race have not been identified.
Hepatic Impairment: Hepatic metabolism accounts for almost 100% of VOLTAREN elimination, so patients with hepatic disease may require reduced doses of VOLTAREN compared to patients with normal hepatic function.
Renal Impairment: Doloflam pharmacokinetics has been investigated in subjects with renal insufficiency. No differences in the pharmacokinetics of Doloflam have been detected in studies of patients with renal impairment. In patients with renal impairment (inulin clearance 60-90, 30-60, and