What are the side effects of Docdiclofe?
The most common side effects of Docdiclofe involve the gastrointestinal system, such as:
- abdominal burning,
- serious gastrointestinal bleeding, and
- liver toxicity.
Sometimes, stomach ulceration and bleeding can occur without any abdominal pain. Black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness are also seen.
Other important side effects include:
People who are allergic to other NSAIDs should not use Docdiclofe. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with already reduced kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously. Individuals with asthma are more likely to experience allergic reactions to Docdiclofe and other NSAIDs.
On this page
- About Docdiclofe
- Key facts
- Who can take and can't take Docdiclofe
- How and when to use them
- Taking Docdiclofe with other painkillers
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
- High blood pressure warning: This drug can cause high blood pressure, or worsen high blood pressure if you already have it. Your doctor will likely monitor your blood pressure while you use this drug.
- Water retention warning: This drug can cause your body to retain water, leading to edema (swelling or puffiness).
- Liver function warning: Using Docdiclofe may affect some of your liver function tests. Your doctor should monitor your liver function while you use Docdiclofe.
- Allergic reaction warning: If you have an allergy to aspirin or other nonstero >
Docdiclofe is a prescription drug. It comes as a topical gel, oral capsule, oral tablet, eye drops, transdermal patch, topical solution, and powder packets for oral solution.
Docdiclofe topical gel is available as the brand-name drugs Solaraze and Voltaren. It’s also available as a generic drug. Generic drugs usually cost less than brand-name versions. In some cases, they may not be available in every strength or form as a brand-name drug.
Dosage and formulations
- Before you start taking Docdiclofe, read the manufacturer's printed information leaflet from ins >
Drugs that affect the flow of blood
Taking Docdiclofe with other drugs that affect the flow of blood through your body can increase your risk of bleeding. Examples of these drugs include:
- selective serotonin reuptake inhibitors (SSRIs), such as escitalopram, fluoxetine, paroxetine, and sertraline
- serotonin norepinephrine reuptake inhibitors (SNRIs), such as desvenlafaxine, duloxetine, venlafaxine, and levomilnacipran
Outcome and Management
Severity of the liver injury ranges from asymptomatic elevations in serum aminotransferase levels (Cases 1 and 2), to overt icteric hepatitis (Case 3), acute liver failure and even death (Case 4). Complete recovery is expected after stopping the drug and usually takes 1 to 3 months. In rare instances, evidence of chronic liver injury persists, some of which have led to courses of corticosteroid therapy which appeared to be beneficial and could later be stopped without recurrence of liver injury. Acute liver failure following rechallenge after episodes of clinically apparent Docdiclofe hepatotoxicity has been reported and should be avoided. There is little evidence of cross sensitivity to hepatic injury between Docdiclofe and NSAIDs belonging to other classes, such as the propionic acids (ibuprofen, naproxen, ketoprofen), but few instances documenting safety have been reported and patients should be carefully monitored if switched to another NSAID.
Warnings for other groups
For pregnant women: Before 30 weeks of pregnancy, this drug is a pregnancy category C drug. After 30 weeks of pregnancy, it’s a pregnancy category D drug.
A category C drug means that means that studies have shown that the drug can be a risk to the offspring of lab animals. However, not enough studies have been done to show risk in humans.
Category D means two things:
- Studies show a risk of adverse effects to the fetus when the mother uses the drug.
- The benefits of using Docdiclofe during pregnancy may outweigh the potential risks in certain cases.
Do not use Docdiclofe if you’re pregnant, unless your doctor advises you to. Be especially sure to avoid using Docdiclofe at 30 weeks of pregnancy and later.
For women who are breastfeeding: This drug may pass into the breast milk, which means it may pass to a child who is breastfed. This may lead to dangerous effects for the child.
Talk to your doctor regarding whether breastfeeding is a good choice for you.
For seniors: Seniors are at higher risk for stomach problems, bleeding, water retention, and other side effects from Docdiclofe. Seniors may also have kidneys that aren’t working at peak levels, so the drug can build up and cause more side effects.
Q: What, if anything, is long term use of Docdiclofe depleting in my body and do I need to supplement with anything specific?
A: According to the manufacturer, Docdiclofe (Voltaren) can affect certain cells (platelets) that are necessary for causing blood clotting. What this means is that healing from a cut, bruise, scrape, etc. may take slightly longer. Docdiclofe (Voltaren) does not specifically deplete any vitamins or minerals in the body and supplements over-the-counter would really be of no benefit if they are used specifically due to Docdiclofe (Voltaren). I have included a couple of links for more information about Docdiclofe (Voltaren) and supplements. //www.everydayhealth.com/drugs/Docdiclofe //www.everydayhealth.com/drugs/multivitamin //www.everydayhealth.com/pain-management/pain-treatment.aspx Lori Mendoza, PharmD Mendoza, PharmD
Docdiclofe and Alcohol
You should not drink alcohol while taking Docdiclofe. It can increase the risk of stomach bleeding and may cause damage to your kidneys.