Cardiovascular Thrombotic Events
Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, including myocardial infarction (MI), and stroke, which can be fatal. Based on available data, it is unclear that the risk for CV thrombotic events is similar for all NSAIDs. The relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV disease. However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses.
To minimize the potential risk for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible. Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even in the absence of previous CV symptoms. Patients should be informed about the symptoms of serious CV events and the steps to take if they occur.
There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID, such as Diclobene, increases the risk of serious gastrointestinal (GI) events (see WARNINGS; Gastrointestinal Bleeding, Ulceration, And Perforation).
Diclobene Vs Ibuprofen side effects
The incidence of these side effects will be increrased if ibuprofen and Diclobene are taken together or overdosed.
Q: How safe is the NSAID Diclobene? The side effects listed on the medication are heart attacks or stroke.
A: FDA has concluded that all non-steroidal anti-inflammatory drugs (NSAIDs), the class of drugs that includes Diclobene, carry an increased risk of heart attack and stroke. As a precaution, it is generally recommended to avoid the use of these drugs in patients with known cardiac risk factors. The risk appears to increase with longer use of the drugs. Always discuss your medical history and each of your medications with your health care provider. For more specific information: //www.everydayhealth.com/drugs/Diclobene
Taking cyclosporine, a drug that weakens your immune system, with Diclobene may increase your risk for kidney problems.
Rated Diclobene for Moderate Pain Report
Cause swelling itching hives breathing problems severe upset stomach throwing up dizziness diarrhea I had to take Benadryl I thought I was going to have to go to the ER never never again this drug for me the interactions or not good
Q: What are the side effects of Diclobene?
A: The most commonly reported side effects of Diclobene (Cataflam, Voltaren-XR) are dyspepsia, nausea, abdominal pain, constipation, headache, dizziness, rash, and drowsiness. More serious (and rarer) reactions include stroke, high blood pressure, GI bleed, and heart attack. However, I have seen this drug used frequently without any problems.
What should I do if I forget a dose?
The powder for solution is usually taken as needed for migraine headaches. If you are taking any other Diclobene product and you forget to take a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.