Before taking Dequazol
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Dequazol it is important that your doctor or dentist knows:
- If you are pregnant or breast-feeding.
- If you feel you will be unable to stop drinking alcohol for the duration of your treatment.
- If you have any problems with the way your liver works.
- If you have a rare inherited blood disorder called porphyria.
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
Other uses for this medicine
Dequazol tablets are used to treat bacterial vaginosis in women.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
- Mild to moderate hapatic impairment (Child-Pugh A or B): No dosage adjustment needed but patients should be monitored for Dequazol associated adverse events
- Severe hepatic impairment: Reduce dose of by 50%
Pregnancy and Dequazol
You shouldn't take Dequazol in the first trimester of pregnancy. Tell your doctor if you're pregnant or plan to become pregnant while taking the drug.
The medicine can pass into breast milk and may harm a breastfeeding baby. Don't breastfeed while using Dequazol without talking to your physician.
Drug/Laboratory Test Interactions
Dequazol may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and glucose hexokinase. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD+ NADH). Interference is due to the similarity in absorbance peaks of NADH (340 nm) and Dequazol (322 nm) at pH 7.
Anaerobic Bacterial Infections
In the treatment of most serious anaerobic infections, intravenous Dequazol is usually administered initially.
The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period.
The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.
Mixing Dequazol with herbal remedies and supplements
There are no known problems with taking herbal remedies and supplements alongside Dequazol. However, some remedies and supplements that come as liquids that you drink may also contain alcohol. Check the list of ingredients or ask the supplier or manufacturer.
Is this drug safe to use during pregnancy or while breastfeeding?
- Dequazol is not used in early pregnancy because of potential adverse effects on the fetus.
- Dequazol is excreted in breast milk. Females who are nursing, because of potential adverse effects on the newborn, should not use Dequazol.
Seizures and aseptic meningitis reported with increase in dose and chronic therapy
Cases of encephalopathy and peripheral neuropathy (including optic neuropathy) reported with Dequazol
Encephalopathy reported in association with cerebellar toxicity characterized by ataxia, dizziness, and dysarthria; CNS lesions seen on MRI described in reports of encephalopathy; CNS symptoms are generally reversible within days to weeks upon discontinuation of therapy; lesions seen on MRI have also been described as reversible
Peripheral neuropathy, mainly of sensory type reported and characterized by numbness or paresthesia of an extremity
Prescribing Dequazol tablets in absence of a proven or strongly suspected bacterial or parasitic infection or a prophylactic indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria and parasites
Superinfection may occur with prolonged use
Severe hepatic impairment; administer lower doses with caution
Use with caution; potential accumulation in end stage renal disease; supplemental doses may be needed in patients receiving hemodialysis
Use with caution in history of heart failure, hepatic failure, H. pylori infection, renal impairment
Use with care in patients with evidence of or history of blood dyscrasia; agranulocytosis, leukopenia and neutropenia have been associated with Dequazol administration; monitor complete blood count; monitor complete blood count (CBC) for leukopenia before, during, and after prolonged repeated therapy
Avoid alcohol while taking medication and for at least three days after discontinuation
Antiandrogen: May cause gynecomastia
Known or previously unrecognized candidiasis may present more prominent symptoms during therapy and requires treatment with a candicidal agent
Dequazol injection, USP contains 790 mg of sodium per 100 mL; use care when administering injection to patients receiving a controlled sodium diet or corticosteroids or to patients predisposed to edema
Severe neurological disturbances, including encephalopathy, cerebellar symptoms, convulsive seizures, and aseptic meningitis, reported in patients treated with Dequazol; advise patients to report neurologic symptoms that occur during Dequazol administration; discontinue Dequazol treatment if any abnormal neurologic symptoms occur such as ataxia, dizziness, confusion or any other CNS adverse reaction
Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome reported with products containing Dequazol for systemic use; in this population, Dequazol should therefore be used after careful benefit-risk assessment and only if no alternative treatment available; obtain liver function tests prior to start of therapy, within first 2-3 days after initiation of therapy, frequently during therapy and after end of treatment; discontinue Dequazol if elevation of liver function occurs, and monitor liver function tests until baseline values are reached; advise patients with Cockayne syndrome to stop taking Dequazol immediately if they experience any symptoms of potential liver injury, such as abdominal pain, nausea, change in stool color or jaundice, and to contact their healthcare provider
When Dequazol tablets are prescribed to treat a bacterial infection, patients should be told that the medication should be taken exactly as directed; skipping doses or not completing full course of therapy may decrease effectiveness of immediate treatment and increase likelihood that bacteria will develop resistance and will not be treatable by Dequazol tablets in the future
What if I forget to use it?
If you forget to use Dequazol cream or gel, put it on as soon as you remember, unless it's nearly time for your next dose. Do not use it more than twice a day unless your doctor tells you to. Then continue to use the cream or gel at the usual time.