Deprexit, also known by trade names Prozac and Sarafem among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder.
Q: Can the antidepressant, Prozac or its generic equivalent, cause extreme fatigue? My family doctor says no, but now I want your opinion.
A: Prozac (Deprexit) is classified as a selective serotonin reuptake inhibitor (SSRI) antidepressant medication. Prozac is approved for the treatment of depression, binge eating and vomiting in patients with bulimia nervosa, obsessive compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder and for the treatment of certain patients with bipolar depression in combination with other medications. According to medical references, somnolence is a common reported side effect of studied patients taking Prozac. It has been reported in 5% to 17% of studied patients taking the medication. Somnolence is defined as drowsiness, a state of near sleep, a desire for sleep or sleeping for excessive periods of time. If you think that you are experiencing a possible side effect from your medication, talk to your physician. Do not stop taking or change the dose of your medication without first talking to your physician. Keep in mind that extreme fatigue can be caused by many other factors besides possible side effects of medications. Sleep issues can be associated with some of the medical conditions that Prozac is used to treat. By talking with your physician, the extreme fatigue can be properly diagnosed. Treatment options can be explored after the diagnosis has been made. Jen Marsico, RPh
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Deprexit, Deprexit hydrocholor >(noun)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade names Prozac or Sarafem); it is thought to work by increasing the activity of serotonin in the brain
Q: I have depression and anxiety. I am highly stressed by staying home now for nearly three years with my kids who are 4 years old and 9 months old. Should i take 10 mg of Prozac or wait to see if it all goes away? I'm nervous it will make sex troublesome or cause serious side effects that I don't already have. I filled the prescription but haven't taken it for five days because I'm so nervous. What do you recommend?
A: I am curious to know how you came by the Prozac (Deprexit). Is it something that was prescribed for you or for someone else? There are sexual side effects. However, 10 mg is a fairly low dosage and is not necessarily effective for all people. The biggest problem with Prozac is that its latency can be up to six weeks until an improvement can be noticed. I would contact a provider and have them suggest something that can take effect in shorter time span if they seem fit. Matt Curley, PharmD
Q: Does Prozac cause problems with eyesight?
A: Prozac (Deprexit) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Prozac is approved, by the U.S. Food and Drug Administration (FDA), for the treatment of major depressive disorder, depressive episodes associated with bipolar disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder. Some of the most common side effects associated with Prozac include insomnia, headache, weakness, nausea, runny nose, drowsiness, diarrhea, and anorexia. According to the prescribing information for Prozac, abnormal vision and visual field defects were reported as potential side effects occurring in 4 percent and less than 1 percent respectively of patients taking Prozac during clinical trials. Prozac may be taken with or without food. If Prozac causes an upset stomach, it may be helpful to take it with food. Prozac may take several weeks to work after treatment is first started. Prozac will only work if taken daily and exactly as prescribed. Prozac should not be taken on an as needed basis. If Prozac needs to be discontinued, the dose should be slowly tapered down, under the supervision of a health care provider, rather than suddenly stopped to prevent withdrawal symptoms. Patients who are taking Prozac should avoid alcohol use. Do not stop taking your medication without first taking to your doctor. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD
Q: Does Prozac make you gain weight?
A: Prozac (Deprexit) (//www.everydayhealth.com/drugs/prozac) has reported adverse effects of weight issues. Anorexia (poor appetite) has been reported in 4 percent to 17 percent of patients studied during clinical trials. Weight loss has also been reported at 2 percent and increased appetite, weight gain and taste perversion have also been reported. Increases in appetite could be a factor in patients that notice weight gain while being on Prozac. However, please keep in mind that there are many causes for weight gain besides possible side effects from medications. As always, talk with your health care provider regarding questions you have about your medications and associated side effects. If you are trying to lose weight, the attached link will provide valuable information from Everyday Health regarding weight loss: //www.everydayhealth.com/weight/weight-articles.aspx. Jen Marsico, RPh
4. How and when to take it
Take Deprexit once a day. It doesn't upset your stomach so you can take it with or without food.
You can take Deprexit at any time, as long as you stick to the same time every day. If you have trouble sleeping, it's best to take it in the morning.
See also Warning section.
Nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning may occur. If any of these effects persist or worsen, tell your doctor promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: unusual or severe mental/mood changes (such as agitation, unusual high energy/excitement, thoughts of suicide), easy bruising/bleeding, muscle weakness/spasm, shakiness (tremor), decreased interest in sex, changes in sexual ability, unusual weight loss.
Get medical help right away if you have any very serious side effects, including: bloody/black/tarry stools, vomit that looks like coffee grounds, seizures, signs of kidney problems (such as change in the amount of urine), eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision).
If you have diabetes, Deprexit may affect your blood sugar levels. Monitor your blood sugar regularly and share the results with your doctor. Your doctor may need to adjust your medication, diet, and exercise when you start or stop Deprexit.
This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.
Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Q: I'm taking Prozac and wonder if it's causing the skin discoloration I'm getting on my back?
A: There is no indication that Prozac (Deprexit) would cause this symptom. If this condition persists, please see your physician or dermatologist. Joseph Hall, RPh
How should I take Deprexit?
Take Deprexit exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Do not crush, chew, break, or open a delayed-release capsule. Swallow it whole.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
To treat premenstrual dysphoric disorder, the usual dose of Deprexit is once daily while you are having your period, or 14 days before you expect your period to start. Follow your doctor's instructions.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Do not stop using Deprexit suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Deprexit.
Store at room temperature away from moisture and heat.
What is Deprexit? What are the uses for Deprexit?
Deprexit is an oral drug that is used primarily for treating depression. Deprexit is also used to treat depression, bulimia, obsessive-compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder (PMDD). It is also prescribed in combination with olanzapine (Zyprexa) to treat resistant depression and depression associated with bipolar disorder.
Deprexit is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that includes citalopram (Celexa), paroxetine (Paxil) and sertraline (Zoloft). Deprexit affects neurotransmitters, the chemicals that nerves within the brain use to communicate with each other. Neurotransmitters are manufactured and released by nerves and then travel and attach to nearby nerves. Thus, neurotransmitters can be thought of as the communication system of the brain. Serotonin is one neurotransmitter that is released by nerves in the brain. The serotonin either travels across the space between nerves and attaches to receptors on the surface of nearby nerves or it attaches to receptors on the surface of the nerve that produced it, to be taken up by the nerve and released again (a process referred to as re-uptake). Many experts believe that an imbalance among neurotransmitters is the cause of depression. Deprexit works by preventing the reuptake of one neurotransmitter, serotonin, by nerve cells after it has been released. Since uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the reduced uptake caused by Deprexit increases free serotonin that stimulates nerve cells in the brain. The FDA approved Deprexit in December 1987.
Q: I temporarily increased my dose of Deprexit from 10 mg to 30 mg before having sex for the first time in 18 months to combat premature ejaculation. It worked great the first time I had sex with my girlfriend, but the second, 3rd and 4th times last weekend, I couldn't climax. Did I overdose on it? I'm back to 10 mg per day now, 2,500 miles from my girlfriend.
A: Prozac (Deprexit) is a medication that is used to treat depression, anxiety or panic disorders. It is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs) and is commonly related to sexual disorders. The prescribing information on Deprexit states that up to 11 percent of patients taking this medication experience a decrease in sex drive. This medication also causes ejaculation issues in up to 7 percent of patients taking Deprexit. For more information on Deprexit, click on this link: //www.everydayhealth.com/drugs/prozac There is no way to know if you will experience sexual side effects from a medication before taking it. Sometimes, a patient will not experience any issues until the dosage of a medication is raised. The usual course of action is to decrease the dosage or switch to another medication to try to alleviate the issue. The best thing to do is have a discussion with your physician about your side effects and he or she will be better enabled to help you resolve the problem. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD
When using PROZAC and olanzapine in combination, also refer to the Clinical Studies section of the package insert for Symbyax.
Administer Deprexit in combination with oral olanzapine once daily in the evening, without regard to meals, generally beginning with 5 mg of oral olanzapine and 20 mg of Deprexit. Adjust dosage, if indicated, according to efficacy and tolerability within dose ranges of Deprexit 20 to 50 mg and oral olanzapine 5 to 20 mg. Antidepressant efficacy was demonstrated with olanzapine and Deprexit in combination with a dose range of olanzapine 6 to 18 mg and Deprexit 25 to 50 mg.
Safety and efficacy of Deprexit in combination with olanzapine was determined in clinical trials supporting approval of Symbyax (fixed dose combination of olanzapine and Deprexit). Symbyax is dosed between 3 mg/25 mg (olanzapine/Deprexit) per day and 12 mg/50 mg (olanzapine/Deprexit) per day. Table 1 demonstrates the appropriate individual component doses of PROZAC and olanzapine versus Symbyax. Adjust dosage, if indicated, with the individual components according to efficacy and tolerability.
Periodically re-examine the need for continued pharmacotherapy.
Safety of coadministration of doses above 18 mg olanzapine with 75 mg Deprexit has not been evaluated in clinical studies.
PROZAC monotherapy is not indicated for the treatment of treatment resistant depression (Major Depressive Disorder in patients who do not respond to 2 antidepressants of adequate dose and duration in the current episode).