Clofen gel

Clofen

  • Active Ingredient: Diclofenac
  • 100 mg
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What is Clofen?

The active ingredient of Clofen brand is diclofenac. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation. The inactive ingredients in Diclofenac sodium delayed-release tablets include: hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose, polyethylene glycol, povidone, propylene glycol, sodium starch glycolate, talc, titanium dioxide, triethyl citrate.

Used for

Clofen is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Frozen Shoulder, Migraine, Muscle Pain, Osteoarthritis, Pain, Period Pain, Rheumatoid Arthritis, Sciatica, Spondyloarthritis.

Side Effect

Possible side effects of Clofen include: Abdominal or stomach bloating, burning, cramping, or pain; cloudy urine; change in consciousness; loss of appetite; lack or loss of strength; change in the ability to see colors, especially blue or yellow; intravenous solution; nervousness.

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Precautions

See also Warning section.

Before taking Clofen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), bleeding or clotting problems, heart disease (such as previous heart attack), high blood pressure, liver disease, growths in the nose (nasal polyps), stomach/intestinal/esophagus problems (such as bleeding, ulcers, recurring heartburn), stroke.

Kidney problems can sometimes occur with the use of NSAID medications, including Clofen. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding, kidney problems, and worsening heart problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Rated Clofen for Osteoarthritis Report

I didn't find this drug to help me at all. I have torn tendons in my maxi and mid glut, arthritis in my hip and lower back pain. I think the doctor gave this drug to me so it wouldn't work and I would come back to him. Ultimately, he mentioned surgery on my back. I am seeing another doctor. Doctors see $$ signs inn this area. Not helping the patient to live a mobile life.

DOSAGE AND ADMINISTRATION

Carefully consider the potential benefits and risks of VOLTAREN ® (Clofen sodium enteric-coated tablets) and other treatment options before deciding to use VOLTAREN. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS; Gastrointestinal Bleeding, Ulceration, And Perforation).

After observing the response to initial therapy with VOLTAREN, the dose and frequency should be adjusted to suit an individual patient’s needs.

For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses (50 mg twice a day or three times a day, or 75 mg twice a day).

For the relief of rheumatoid arthritis, the recommended dosage is 150-200 mg/day in divided doses (50 mg three times a day. or four times a day, or 75 mg twice a day.).

For the relief of ankylosing spondylitis, the recommended dosage is 100-125 mg/day, administered as 25 mg four times a day, with an extra 25-mg dose at bedtime if necessary.

Different formulations of Clofen are not necessarily bioequivalent even if the milligram strength is the same.

Rated Clofen for Osteoarthritis Report

It was an effective pain reliever for my hip, but a few days after taking 75 mg twice a day the muscles in my pelvis area developed pain and prevented me from standing and walking. My doctor advised me to stop this medication.

COMMON BRAND(S): Voltaren

GENERIC NAME(S): Clofen Sodium

Nonsteroidal anti-inflammatory drugs (including Clofen) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while using this drug but is more likely if you use it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not use this drug right before or after heart bypass surgery (CABG).

Also, this drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This side effect can occur without warning symptoms at any time while using Clofen. Older adults may be at higher risk for this effect. (See also Precautions and Drug Interactions sections.)

Stop using Clofen and get medical help right away if you notice any of the following rare but very serious side effects: black/bloody stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden vision changes, slurred speech.

Talk with your doctor or pharmacist about the benefits and risks of using this medication.

See also Warning section.

This medication is used to relieve joint pain from arthritis. Clofen belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.

Warnings for other groups

For pregnant women: Before 30 weeks of pregnancy, this drug is a pregnancy category C drug. After 30 weeks of pregnancy, it’s a pregnancy category D drug.

A category C drug means that means that studies have shown that the drug can be a risk to the offspring of lab animals. However, not enough studies have been done to show risk in humans.

Category D means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother uses the drug.
  2. The benefits of using Clofen during pregnancy may outweigh the potential risks in certain cases.

Do not use Clofen if you’re pregnant, unless your doctor advises you to. Be especially sure to avoid using Clofen at 30 weeks of pregnancy and later.

For women who are breastfeeding: This drug may pass into the breast milk, which means it may pass to a child who is breastfed. This may lead to dangerous effects for the child.

Talk to your doctor regarding whether breastfeeding is a good choice for you.

For seniors: Seniors are at higher risk for stomach problems, bleeding, water retention, and other side effects from Clofen. Seniors may also have kidneys that aren’t working at peak levels, so the drug can build up and cause more side effects.

Clofen Overdose

If you suspect an overdose, you should contact a poison-control center or emergency room immediately. You can get in touch with a poison-control center at (800) 222-1222.

Warnings for people with certain health conditions

For people with high blood pressure or water retention: Tell your doctor before using Clofen. Your heart may already be working hard, and adding an NSAID can increase this workload.

For people with ulcer or digestive bleeding: If you’ve had an ulcer or bleeding from your digestive system, ask your doctor before using Clofen. You’re at increased risk for another bleed.

For people with kidney disease or taking diuretics: If you have kidney disease or take diuretics (water pills), there’s a risk this drug can affect your kidneys’ ability to remove excess water from your body. Ask your doctor if Clofen is the right drug for you.

For people with asthma and aspirin reactions: If you have asthma and you react to aspirin, you could have a bad reaction to Clofen. Talk to your doctor before using the drug.

Clofen interactions and warnings

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking your Clofen dosage, it is important that your doctor knows:

  • If you have asthma or any other allergic disorder.
  • If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
  • If you have a heart condition, or a problem with your blood vessels or circulation.
  • If you are pregnant or breastfeeding.
  • If you have high blood pressure.
  • If you have any blood clotting problems.
  • If you have a connective tissue disorder, such as a condition called systemic lupus erythematosus (SLE).
  • If you have problems with the way your liver works, or problems with the way your k >

Clofen and breastfeeding

Clofen isn't usually recommended if you're breastfeeding

It's safer to take another anti-inflammatory medicine, such as ibuprofen.

Based on available data, Clofen may be present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for VOLTAREN and any potential adverse effects on the breastfed infant from the VOLTAREN or from the underlying maternal condition.

One woman treated orally with a Clofen salt, 150 mg/day, had a milk Clofen level of 100 mcg/L, equivalent to an infant dose of about 0.03 mg/kg/day. Clofen was not detectable in breast milk in 12 women using Clofen (after either 100 mg/day orally for 7 days or a single 50 mg intramuscular dose administered in the immediate postpartum period).

Rated Clofen for Myalgia Report

The Oral Clofen was horrendous on my stomach from the first pill. Didn't help with all over connective tissue pain. Stopped taking it after 2 pills. That Said: the Topical Clofen gel works miracles on almost All types of pain including arthritis to muscle and even headaches. I rub this gel (light cream) into all parts of body and the pain is either reduced or completely gone. Don't be concerned about the amount of topical gel you rub into the body as only a tiny (less than 4 percent) of the active ingredient makes it into the body causing issues. No issues at all with the topical and many doctors and patients view this gel as a real pain reducer. I have literally rubbed this gel onto arms, legs, back, neck and forehead and horrendous pain reduced hugely. With the war on opioids being waged against chronic pain patients this is one fantastic pain reducing weapon. Slather this on, rub it in, but do Not take the oral version of Clofen.

Clofen is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. However, due to first-pass metabolism, only about 50% of the absorbed dose is systemically available (see Table 1). Food has no significant effect on the extent of Clofen absorption. However, there is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of PK Parameter Normal Healthy Adults (20-48 years) Mean Coefficient of Mean Variation (%) Absolute Bioavailability (%) 55 40 Tmax (hr) 2.3 69 Oral Clearance (CL/F; mL/min) 582 23 Renal Clearance (% unchanged drug in urine)

Methotrexate

Taking methotrexate with Clofen can lead to harmful levels of methotrexate in your body. This can raise your risk of infection and kidney issues.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Allergic reaction. Symptoms can include:
    • itching
    • rash
    • breathing problems
    • hives
  • swelling of the feet or ankles
  • increased blood pressure
  • increased weight
  • very dark stools
  • blood in your stool
  • Bruising more easily
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Clofen topical gel can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Clofen are listed below.

    Rated Clofen for Osteoarthritis Report

    I had my hip replaced 2 years ago. My hip was dead before so I have nothing bad to say about having my hip replaced other than the fact that I had a mild pain all the time and then is severe pain every once in awhile. The effects of the pain made me make choices of things I would do and wouldn't do. This drug it's a lifesaver it is made my life normal again like it was before I had my hip replaced with physical therapy in this drug I believe I will get back to normal again I did not believe that before.

    What other drugs will affect Clofen?

    Ask your doctor before using Clofen if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

    Tell your doctor about all your current medicines and any you start or stop using, especially:

    a blood thinner (warfarin, Coumadin, Jantoven);

    heart or blood pressure medication, including a diuretic or "water pill";

    other forms of Clofen (Flector, Pennsaid, Solaraze, Voltaren Gel);

    other NSAIDs - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), indomethacin, meloxicam, and others; or

    steroid medicine (prednisone and others).

    This list is not complete. Other drugs may interact with Clofen, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

    Q: What, if anything, is long term use of Clofen depleting in my body and do I need to supplement with anything specific?

    A: According to the manufacturer, Clofen (Voltaren) can affect certain cells (platelets) that are necessary for causing blood clotting. What this means is that healing from a cut, bruise, scrape, etc. may take slightly longer. Clofen (Voltaren) does not specifically deplete any vitamins or minerals in the body and supplements over-the-counter would really be of no benefit if they are used specifically due to Clofen (Voltaren). I have included a couple of links for more information about Clofen (Voltaren) and supplements. //www.everydayhealth.com/drugs/Clofen //www.everydayhealth.com/drugs/multivitamin //www.everydayhealth.com/pain-management/pain-treatment.aspx Lori Mendoza, PharmD Mendoza, PharmD


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