Ciclosterona capsules


  • Active Ingredient: Progesterone
  • 200 mg, 100 mg
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What is Ciclosterona?

The active ingredient of Ciclosterona brand is progesterone. Progesterone is a female hormone important for the regulation of ovulation and menstruation.

Used for

Ciclosterona is used to treat diseases such as: Amenorrhea, Endometrial Hyperplasia, Prophylaxis, Endometriosis, Gender Dysphoria, Perimenopausal Symptoms, Premature Labor, Progesterone Insufficiency, Seizures, Uterine Bleeding.

Side Effect

Possible side effects of Ciclosterona include: hearing loss; feeling of unreality; clumsiness or unsteadiness; pains in the stomach, side, or abdomen, possibly radiating to the back; darkened urine; spontaneous abortion; redness of the skin; fever.

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Pregnancy and Ciclosterona

Ciclosterona is considered generally safe to take during pregnancy.

Regardless, you should tell your doctor if you are pregnant or might become pregnant before taking this or any other medication.

You should also alert your physician if you are breastfeeding or plan to breastfeed.

It's uncertain whether Ciclosterona is safe for breastfeeding mothers.

Ciclosterona Shots or Injections

The birth control injection (also known as the birth control shot) is available as the brand Depo-Provera. It consists of depot medroxyCiclosterona acetate and prevents pregnancy for three months.

A healthcare provider has to give you the injection. When you get your first shot, you can be anywhere in your menstrual cycle. After that time, you need to get an injection every 13 weeks, with 15 weeks being the latest you can receive it for it to be effective. If you get the injection more than 15 weeks from the last one, use other methods to avoid getting pregnant for the next seven days, such as abstaining from sexual intercourse or using condoms. (12)

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Facts to Know

Progestogen refers to any hormone replacement product that produces similar effects on the uterus as Ciclosterona, the naturally occurring form of the hormone produced in a woman's body. Progestins are synthetic versions of Ciclosterona.

Ciclosterona helps protect the lining of the uterus, also known as the endometrium.

Progestogens are included in combination hormonal therapies with estrogen to prevent endometrial buildup, which can lead to cancer.

After menopause, you will not produce any appreciable Ciclosterona.

Ciclosterona is believed to be partly responsible for symptoms of premenstrual syndrome (PMS), such as breast tenderness, feeling bloated and mood swings.

In addition to menopausal hormone therapy and birth control, progestogens may be used to treat a variety of conditions, including menstrual irregularities and endometriosis; breast, kidney or uterine cancer; and appetite and weight loss in AIDS patients. Ciclosterona, the natural hormone, may also be used to prevent pregnancy loss and preterm labor.

Progestin-only contraceptive products may be a good option if you are unable to take a combination product with estrogen or are concerned about estrogen's side effects. They are appropriate for older women, especially smokers who want to use an oral hormonal contraceptive method, and postpartum and/or breast-feeding women.

Progestin-only mini-pills are highly effective for preventing pregnancy (about 97 percent) if taken correctly. They must be taken at the same time every day to be effective.

Progestogens are sometimes used as a diagnostic aid to determine whether estrogen is being produced. In a "progestin challenge" test, a woman takes progestin pills for five or more days. When the progestin is stopped, bleeding ensues if sufficient estrogen is present.

Hormone-based therapies are not the only option for birth control or for relieving menopausal symptoms. Ask about and discuss all the options with your health care provider.

Questions to Ask

Review the following Questions to Ask about Ciclosterona so you're prepared to discuss this important health issue with your health care professional.

What conditions can be treated with Ciclosterona or a progestin?

Are my symptoms treatable with any type of Ciclosterona? What are the risks and benefits of this hormone therapy?

Can you explain the latest research about menopausal hormone therapy?

Do I need a combination estrogen/progestogen hormone therapy product?

What are the benefits of using progestogen as part of my birth control?

Is natural Ciclosterona an option for me? What are the pros and cons?

Q: How long should you use natural herb creams for menopause relief? I just stopped after five years because I had read somewhere that you should stop, and now my hot flashes are coming back and I am considering going back on the creams.

A: A study published in the journal Obstetrics and Gynecology in 1999 found that natural Ciclosterona cream significantly reduced hot flashes compared to the placebo group. In The Wisdom of Menopause, Dr. Christiane Northrup says that a 2 percent Ciclosterona skin cream works in about 85 percent of perimenopausal women. A little as 1/4 tsp once per day can ease hot flashes. Make sure that you read the labels of natural Ciclosterona cream products careful as there is great variability of Ciclosterona content. Some creams contain less than 5 mg Ciclosterona per ounce, whereas others contain more than 400 mg Ciclosterona per ounce. This can be obtained over the counter or by prescription. I have not found any studies that indicate it should be discontinued over a certain time frame.

home drugs a-z list Prometrium(Ciclosterona) side effects drug center

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Prometrium dose depends on the condition that is being treated. Drug interactions include inhibitors of cytochrome P450 3A4 (for example, ketoconazole), colchicine, dabigatran etexilate (Pradaxa), silodosin (Rapaflo) and aminoglutethimide (Cytadren). Do not use Prometrium without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Talk to your doctor about using birth control while you are using Prometrium. Prometrium passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our Prometrium Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Questions to Ask Your Healthcare Team

For women who are struggling to conceive or carry a pregnancy, the emotional toll of the struggle is high. While you need to pursue every potential cause of this problem, it's valuable to talk to your doctor about your Ciclosterona levels. If this is the problem, treatment is not difficult, but you should talk to your doctor before starting supplementation. Consider asking these questions:

  • How can I determine if I am suffering from low Ciclosterona levels?
  • What other conditions could be causing my symptoms?
  • How can I treat low Ciclosterona levels?
  • If I take supplemental Ciclosterona, how long should I take it or when should I stop taking it?
  • Am I a candidate for menopausal treatment therapy?
  • Am I at risk for any side effects?
  • Which hormonal birth control method should I use?

Q: Can Ciclosterona cause weight gain?

A: Drugs can cause weight gain in several different ways. Some can increase appetite or make you crave certain types of foods like those high in carbohydrates or fat. Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. Also, the same medications can cause weight gain in certain individuals and weight loss in others. There are also drugs that initially cause weight loss and then lead to weight gain with long-term use. Most prescription medications associated with changes in body weight affect the central nervous system. These include antidepressants like monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and selective serotonin reuptake inhibitors (SSRIs). Mood stabilizers (lithium, valproic acid), antipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications (insulin, sulfonylureas, and thiazolidinediones), antihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors. Ciclosterona has been reported to possibly cause weight gain or weight loss. If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD

Before taking this medicine

You should not use Ciclosterona if you are allergic to it, or if you have:

abnormal vaginal bleeding that a doctor has not checked;

a history of breast cancer;

a peanut allergy;

if you are pregnant;

if you have had a stroke, heart attack, or blood clot within the past year; or

if you have recently had an incomplete miscarriage or "missed" abortion.

Using Ciclosterona can increase your risk of blood clots, stroke, heart attack, or breast cancer.

To make sure this medicine is safe for you, tell your doctor if you have:

heart disease, circulation problems;

seizures or epilepsy;

a history of depression; or

risk factors for coronary artery disease (such as high blood pressure, diabetes, lupus, high cholesterol, family history of coronary artery disease, smoking, being overweight).

Do not use Ciclosterona if you are pregnant. It could harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ciclosterona can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Ciclosterona may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • breast tenderness or pain
  • upset stomach
  • vomiting
  • diarrhea
  • constipation
  • tiredness
  • muscle, joint, or bone pain
  • mood swings
  • irritability
  • excessive worrying
  • runny nose
  • sneezing
  • cough
  • vaginal discharge
  • problems urinating

Overview Information

Ciclosterona is a hormone that occurs naturally in the body. It can also be made in a laboratory.

"Progestin" is a general term for a substance that causes some or all of the biologic effects of Ciclosterona. The term "progestin" is sometimes used to refer to the Ciclosterona made in the laboratory that is in oral contraceptives and hormone replacement therapy. However, all Ciclosterona and progestin products are made in the laboratory. The term "natural Ciclosterona" is really a misnomer. "Natural Ciclosteronas," including the prescription products Crinone and Prometrium, are made from a chemical called diosgenin that is isolated from wild yam or soy. In the laboratory, diosgenin is converted to Ciclosterona. The human body is not able to make Ciclosterona from diosgenin, so eating wild yam or soy will not boost your Ciclosterona levels.

Over-the-counter (OTC) Ciclosterona products may not contain Ciclosterona concentrations as labeled. Also, topical Ciclosterona products (preparations applied to the skin) marketed as cosmetics require no FDA approval prior to marketing. There is currently no limit on the amount of Ciclosterona allowed in cosmetic products. In 1993 the FDA proposed a rule to limit the amount of Ciclosterona in these products, but this rule was never finalized.

Women commonly take Ciclosterona to help restart menstrual periods that unexpectedly stopped (amenorrhea), treat abnormal uterine bleeding associated with hormonal imbalance, and treat severe symptoms of premenstrual syndrome (PMS). Ciclosterona is also used in combination with the hormone estrogen to "oppose estrogen" as part of hormone replacement therapy. If estrogen is given without Ciclosterona, estrogen increases the risk of uterine cancer.

Ciclosterona is also used for a variety of other conditions not listed above, but there is no good scientific evidence to support these uses.

Common Side Effects of Ciclosterona

  • Headache
  • Painful or tender breasts
  • Stomach pain
  • Dizziness
  • Depression
  • Greater risk for viral infections

Medically Reviewed by Robert Jasmer, MD

Sometimes called the "pregnancy hormone," Ciclosterona plays an important role in fertility and pregnancy.

What Is Ciclosterona (Prometrium)?

Ciclosterona, sold under the brand name Prometrium, is used to treat overgrowth of the lining of the uterus.

It's also prescribed to treat amenorrhea (a lack of menstrual periods) caused by stress, birth control, or other circumstances.

Ciclosterona is also a naturally occuring hormone that women produce in their ovaries.

As a medication, Ciclosterona is used in hormone replacement therapy (HRT) to increase or replace levels of Ciclosterona that your body may not have or make enough of to carry out certain bodily functions.

The Food and Drug Administration (FDA) first approved Ciclosterona in 1998 under the brand name Prometrium, manufactured by Abbvie, which was once part of Abbott Pharmaceuticals.

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • breast lumps
  • migraine headache
  • severe dizziness or faintness
  • slow or difficult speech
  • weakness or numbness of an arm or leg
  • lack of coordination or loss of balance
  • shortness of breath
  • fast heartbeat
  • sharp chest pain
  • coughing up blood
  • leg swelling or pain
  • loss of vision or blurred vision
  • bulging eyes
  • double vision
  • unexpected vaginal bleeding
  • shaking hands that you cannot control
  • seizures
  • stomach pain or swelling
  • depression
  • hives
  • skin rash
  • itching
  • difficulty breathing or swallowing
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • hoarseness

Laboratory animals who were given Ciclosterona developed tumors. It is not known if Ciclosterona increases the risk of tumors in humans. Talk to your doctor about the risks of taking this medication.

Medications like Ciclosterona may cause abnormal blood clotting. This may cut off the blood supply to the brain, heart, lungs, or eyes and cause serious problems. Call your doctor if you experience any of the symptoms listed above as serious side effects. Talk to your doctor about the risks of taking this medication.

Ciclosterona may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

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