Chemagyl capsules

Chemagyl

  • Active Ingredient: Metronidazole
  • 500 mg, 400 mg, 250 mg, 200 mg
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What is Chemagyl?

The active ingredient of Chemagyl brand is metronidazole. Metronidazole is an antibiotic that fights bacteria.

Used for

Chemagyl is used to treat diseases such as: Amebiasis, Aspiration Pneumonia, Bacteremia, Bacterial Infection, Bacterial Vaginitis, Balantidium coli, Bone infection, Clostridial Infection, Crohn's Disease, Acute, Crohn's Disease, Maintenance, Deep Neck Infection, Dental Abscess, Dientamoeba fragilis, Diverticulitis, Dracunculiasis, Endocarditis, Giardiasis, Helicobacter Pylori Infection, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Meningitis, Nongonococcal Urethritis, Pelvic Inflammatory Disease, Peritonitis, Pneumonia, Pouchitis, Pseudomembranous Colitis, Skin or Soft Tissue Infection, STD Prophylaxis, Surgical Prophylaxis, Trichomoniasis.

Side Effect

Possible side effects of Chemagyl include: unusual tiredness or weakness; dry mouth; cough; dizziness or lightheadedness; eye pain; irritability; back pain; burning, numbness, tingling, or painful sensations in the hands or feet.

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Introduction

Chemagyl is a nitroimidazole derivative bactericidal agent widely used in the treatment of many anaerobic and certain protozoan and parasitic infections. Chemagyl has been linked to rare instances of acute, clinically apparent liver injury.

Geriatric Use

In elderly geriatric patients, monitoring for Chemagyl associated adverse events is recommended (see CLINICAL PHARMACOLOGY, PRECAUTIONS). Decreased liver function in geriatric patients can result in increased concentrations of Chemagyl that may necessitate adjustment of Chemagyl dosage (see DOSAGE AND ADMINISTRATION).

Before taking Chemagyl

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Chemagyl it is important that your doctor or dentist knows:

  • If you are pregnant or breast-feeding.
  • If you feel you will be unable to stop drinking alcohol for the duration of your treatment.
  • If you have any problems with the way your liver works.
  • If you have a rare inherited blood disorder called porphyria.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.

Mechanism of Injury

The cause of acute liver injury due to Chemagyl is probably immunoallergic, given the short latency period and recurrence with rechallenge. However, the frequency of severe hepatotoxicity in children with Cockayne syndrome suggests a direct toxic effect, probably involving breaks in double stranded DNA.

What if I take too much?

Accidentally taking an extra dose of Chemagyl is unlikely to harm you or your child.

Speak to your pharmacist or doctor if you're worried or you take more than 1 extra dose.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another condition unless told to do so by your doctor. A different medication may be necessary in those cases.

Sun exposure can worsen rosacea. Limit exposure to the sun by wearing a wide-brimmed hat and using a sunscreen that is SPF 15 or greater. If your brand already contains a sunscreen, you should use a regular sunscreen (without the Chemagyl) on areas of skin not treated with this medication.

Avoid certain triggers that may worsen rosacea such as wind, hot beverages, spicy foods, alcohol, and extreme cold. Discuss with your doctor.

Serious Side Effects of Chemagyl

Tell your doctor immediately if you experience any of the following serious side effects:

  • Numbness or tingling in the hands or feet
  • White patches or sores in the mouth or on the lips
  • Painful urination
  • Vision problems or pain behind the eyes
  • Fever or chills
  • Trouble concentrating
  • Mood or behavior changes
  • Confusion
  • Tremors
  • Seizures
  • Slurred speech
  • Stiff neck
  • Muscle twitching
  • Joint pain
  • Signs of an allergic reaction, which may include rash, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat

Case 1. Elevations in serum aminotransferase levels during intravenous Chemagyl therapy.

A 58 year old man underwent prostate biopsy and cystoscopy and 32 hours later developed fever and was admitted for treatment of suspected urosepsis. After a combination of cephalosporin and tobramycin failed to affect his course, intravenous Chemagyl (500 mg every 6 hours) was added. He had rapid clinical improvement, but then complained of abdominal pain, nausea, headache, and a metallic taste. Chemagyl was stopped after 5 days, and he was switched on oral cefaclor. At the same time, serum ALT and alkaline phosphatase levels were found to be elevated. Physical exam showed slight hepatomegaly without jaundice. Hepatitis B serology was negative. Over the following week, the patient recovered symptomatically and was discharged home. All laboratory tests were normal 4 weeks after stopping Chemagyl.

3. Who can and can't take metron >

Chemagyl can be taken by most adults and children. Chemagyl isn't suitable for some people.

To make sure the tablets, liquid or suppositories are safe for you, tell your doctor if you:

  • have had an allergic reaction to Chemagyl or any other medicines in the past
  • are pregnant or breastfeeding
  • have liver problems
  • are having dialysis
  • feel you won't be able to stop drinking alcohol while using Chemagyl

To make sure the external cream or gel is safe for you, tell your doctor if you:

  • have had an allergic reaction to Chemagyl or any other medicines (including any creams or ointments) in the past
  • are pregnant or breastfeeding

To make sure the vaginal gel is safe for you, tell your doctor if you:

  • have had an allergic reaction to Chemagyl or any other medicines in the past
  • are pregnant or breastfeeding
  • have liver problems
  • feel you won't be able to stop drinking alcohol while using Chemagyl
  • think you may have vaginal thrush

Cautions

Seizures and aseptic meningitis reported with increase in dose and chronic therapy

Cases of encephalopathy and peripheral neuropathy (including optic neuropathy) reported with Chemagyl

Encephalopathy reported in association with cerebellar toxicity characterized by ataxia, dizziness, and dysarthria; CNS lesions seen on MRI described in reports of encephalopathy; CNS symptoms are generally reversible within days to weeks upon discontinuation of therapy; lesions seen on MRI have also been described as reversible

Peripheral neuropathy, mainly of sensory type reported and characterized by numbness or paresthesia of an extremity

Prescribing Chemagyl tablets in absence of a proven or strongly suspected bacterial or parasitic infection or a prophylactic indication is unlikely to provide benefit to patient and increases risk of development of drug-resistant bacteria and parasites

Superinfection may occur with prolonged use

Severe hepatic impairment; administer lower doses with caution

Use with caution; potential accumulation in end stage renal disease; supplemental doses may be needed in patients receiving hemodialysis

Use with caution in history of heart failure, hepatic failure, H. pylori infection, renal impairment

Use with care in patients with evidence of or history of blood dyscrasia; agranulocytosis, leukopenia and neutropenia have been associated with Chemagyl administration; monitor complete blood count; monitor complete blood count (CBC) for leukopenia before, during, and after prolonged repeated therapy

Avoid alcohol while taking medication and for at least three days after discontinuation

Antiandrogen: May cause gynecomastia

Known or previously unrecognized candidiasis may present more prominent symptoms during therapy and requires treatment with a candicidal agent

Chemagyl injection, USP contains 790 mg of sodium per 100 mL; use care when administering injection to patients receiving a controlled sodium diet or corticosteroids or to patients predisposed to edema

Severe neurological disturbances, including encephalopathy, cerebellar symptoms, convulsive seizures, and aseptic meningitis, reported in patients treated with Chemagyl; advise patients to report neurologic symptoms that occur during Chemagyl administration; discontinue Chemagyl treatment if any abnormal neurologic symptoms occur such as ataxia, dizziness, confusion or any other CNS adverse reaction

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome reported with products containing Chemagyl for systemic use; in this population, Chemagyl should therefore be used after careful benefit-risk assessment and only if no alternative treatment available; obtain liver function tests prior to start of therapy, within first 2-3 days after initiation of therapy, frequently during therapy and after end of treatment; discontinue Chemagyl if elevation of liver function occurs, and monitor liver function tests until baseline values are reached; advise patients with Cockayne syndrome to stop taking Chemagyl immediately if they experience any symptoms of potential liver injury, such as abdominal pain, nausea, change in stool color or jaundice, and to contact their healthcare provider

When Chemagyl tablets are prescribed to treat a bacterial infection, patients should be told that the medication should be taken exactly as directed; skipping doses or not completing full course of therapy may decrease effectiveness of immediate treatment and increase likelihood that bacteria will develop resistance and will not be treatable by Chemagyl tablets in the future

What if I use too much?

If you accidentally use too much gel it's unlikely to harm you.

Talk to your pharmacist or doctor if you're worried.

It's unusual to have side effects when using Chemagyl cream or gel. However there can be some common side effects with the tablets, suppositories or vaginal gel.

Do not drink alcohol while taking the tablets or liquid or using the vaginal gel or suppositories. It can give you severe side effects such as feeling or being sick, stomach pain, hot flushes, a pounding heartbeat (palpitations) and a headache. After finishing your treatment, wait for 2 days before drinking alcohol again. This allows the Chemagyl to leave your body.

Summary

Chemagyl (Flagyl, Flagyl ER) is a prescription antibiotic medication prescribed for the treatment of a variety of parasitic and bacterial infections of the vagina, gynecological area, skin, intra-abdominal cavity, blood, bone, joint, nervous system, and heart. For example, giardia, bacterial vaginosis, pelvic inflammatory disease (PID), C. difficile, H. pylori, STDs (trichomonas), acne rosacea, peritonitis, endometriosis, endomyometritis, tubo-ovarian abscess, bacterial septicemia, meningitis, brain abscess, pneumonia, lung abscess, and endocarditis.

Warfarin And other Oral Anticoagulants

Chemagyl has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time. When FLAGYL is prescribed for patients on this type of anticoagulant therapy, prothrombin time and INR should be carefully monitored.

Chemagyl and Other Interactions

Chemagyl may make your skin more sensitive to sunlight.

Avoid prolonged exposure to the sun and wear sunscreen, protective clothing, and sunglasses when outdoors.

The medicine may also make you dizzy. Don't drive or operate machinery until you know how Chemagyl affects you.


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