Celonax tablets


  • Active Ingredient: Naproxen
  • 500 mg, 250 mg
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What is Celonax?

The active ingredient of Celonax brand is naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reducing hormones that cause inflammation and pain in the body. C14H14O3 M.W. 230.26 Naproxen has a molecular weight of 230.26 and a molecular formula of C14H14O3. Naproxen USP is an odorless, white to off-white crystalline substance powder. It is lipid-soluble, practically insoluble in water, soluable in alcohol and in methanol at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of Naproxen at pH 7.4 is 1.6 to 1.8. Naproxen Oral Suspension USP for oral administration contains 125 mg Naproxen USP per 5 mL and the following inactive ingredients: FD&C Yellow #6, fumaric acid, imitation orange flavor, imitation pineapple flavor, magnesium aluminum silicate, methylparaben, purified water, sodium chloride, sorbitol solution and sucrose. It has a sodium content of 39.3 mg/5 mL, 1.71 mEq/5 mL, with a pH range of 2.2 to 3.7.

Used for

Celonax is used to treat diseases such as: Ankylosing Spondylitis, Aseptic Necrosis, Back Pain, Bursitis, Chronic Myofascial Pain, Costochondritis, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia, Fever, Frozen Shoulder, Gout, Acute, Headache, Juvenile Rheumatoid Arthritis, Muscle Pain, Neck Pain, Osteoarthritis, Pain, Period Pain, Radiculopathy, Rheumatoid Arthritis, Sciatica, Spondylolisthesis, Tendonitis, Transverse Myelitis.

Side Effect

Possible side effects of Celonax include: burning upper abdominal or stomach pain; coma; difficulty with moving; dry mouth; swelling.

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Maximum recommended daily dose

People should only use OTC Celonax for a short-term period of between 3–5 days for pain and no more than 3 days for fever. If they need ongoing treatment, people should consult their doctor first.

For children between 2–12 years old, the maximum daily dose by weight is 20 mg/kg. They should not be taking more than 1,000 mg in 24 hours.

When OTC medications, children 12 years and older should not take more than 660 mg in 24 hours.

Studies have not shown any benefit in using daily doses higher than 1,000 mg, but some sources suggest a maximum of 1,650 mg per day for up to 6 months for arthritis.

The frequency and severity of side effects that Celonax causes depend on several factors.

Considerations include the dose and duration of treatment, other medical diagnoses a person may have, and individual risk factors.

The following sections discuss the common and serious side effects of Celonax.

Why it’s used

Prescription Celonax oral tablets are used to treat pain and inflammation in a variety of conditions. It’s approved to treat:


  • Store Celonax at room temperature between 68°F and 77°F (20°C and 25°C).
  • Keep the container tightly closed and protect the drug from light.

Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis

People can manage the symptoms of osteoarthritis, which is commonly known as arthritis, rheumatoid arthritis, and ankylosing spondylitis with a dose of 220 mg to 550 mg of Celonax every 12 hours. Celonax does not cure these conditions but offers relief from pain and inflammation.

Ibuprofen vs. Celonax

Ibuprofen (Motrin, Advil) and Celonax (Aleve) are both available under generic/store-brand formulations, as well as their original brand names. Although some people do report that generics work differently for them than brand drugs, the FDA requires generic formulations to perform similarly to brands. They acknowledge a possible slight variation at times, just as between batches of the brand medicine, but the FDA monitors them closely. Any undesired effects should be reported to the FDA.


According to Wikipedia, ibuprofen was discovered in 1961 by Stewart Adams and initially marketed as Brufen. It was first sold in 1969 in the United Kingdom and in the United States in 1974. Ibuprofen is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.

The company Syntex first marketed Celonax in 1976 as the prescription drug Naprosyn. They sold Celonax sodium under the brand name Anaprox in 1980. It remains a prescription-only drug in much of the world. In the United States, however, the FDA approved it as an over-the-counter (OTC) drug in 1994.

One decision-maker when it comes to ibuprofen vs. Celonax may be how long the pain relief is expected to last. Celonax lasts longer than ibuprofen. The half-life of ibuprofen is two to four hours, while Celonax is 12 to 17 hours. (Half-life is when half the original dose is still circulating in your bloodstream.) In layman’s terms, you take ibuprofen once every four to six hours, while Celonax is only repeated once every eight to 12 hours.

According to iodine.com, ibuprofen relieves pain, fever, and swelling. Celonax is similar, relieving pain, fever, and inflammation. Ibuprofen is available for children, but Celonax is not.

Dosage for tendonitis, bursitis, and menstrual pain

Adult dosage (ages 18 years and older)


Immediate-release oral tablet

  • The initial dose is 500 mg, followed by 250 mg every 6 to 8 hours as needed.
  • The maximum daily dose on day 1 of therapy is 1,250 mg. Additional daily doses should not exceed 1,000 mg.

Delayed-release oral tablet

  • The initial dose is 1,000 mg once daily.
  • The dose may be temporarily increased to 1,500 mg once daily if greater pain relief is needed.

Celonax sodium:

Immediate-release oral tablet

  • The initial dose is 550 mg, followed by 275 mg every 6 to 8 hours or 550 mg every 12 hours as needed.
  • · The maximum daily dose on day 1 of therapy is 1,375 mg. Additional daily doses should not exceed 1,100 mg.

Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Special dosage considerations

If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be dangerous.

Q: I used to take Darvocet because I have sciatica pain and the doctor took me off of it and put me on Celonax 500 mg twice daily. Now I am having shortness of breath and so tired I can hardly walk. I have been on this for one month. Could this medicine be causing me shortness of breath and the feeling of passing out?

A: Celonax is a non-steroidal anti-inflammatory drug (or NSAID) that is used to treat pain and inflammation. The most common side effects of Celonax are heartburn, abdominal pain, nausea, constipation, headache, dizziness, drowsiness, itching, skin rashes, ringing of the ears, swelling, and shortness of breath. Celonax, like other NSAIDs, may cause serious cardiovascular side effects, such as heart attack or stroke. Although serious cardiovascular events can occur without warning symptoms, patients should be aware of the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should contact their health care provider if any of these occur. Michelle McDermott, PharmD

Celonax Warnings

Celonax may raise your risk for heart attacks and stroke.

Heart and stroke risk is greater if you have a history of or risk factors for heart disease.

Celonax may cause ulcers and bleeding in your gastrointestinal (GI) tract. Ulcer and bleeding risk is higher if you are elderly.

Because elderly people are more likely to have side effects, you should take the lowest possible effective dose if you are over age 65.

This drug is not recommended for children younger than 2 years.

Always tell your doctor if you are taking Celonax before having any surgical procedure, including dental surgery.

Before you take Celonax, it is important to tell your doctor or pharmacist about any allergies to NSAIDs.

In addition to stroke, heart disease, and gastrointestinal bleeding, other conditions also carry warnings related to Celonax use, so tell your doctor or pharmacist if you have any of these conditions:

  • High blood pressure
  • Fluid retention
  • Kidney disease
  • Liver disease
  • Anemia
  • Asthma
  • Nasal congestion or nasal polyps
  • Stomach ulcer
  • Inflammatory bowel disease (IBD)

Warnings for certain groups

For people with stomach problems: If you have a history of ulcers or stomach or intestinal bleeding, Celonax increases your risk of stomach or intestinal bleeding.

For people with kidney disease: Celonax can cause kidney damage when it’s used for a long time. If you have serious kidney disease, you should not use this drug.

For pregnant women: Celonax is a pregnancy category C drug. That means two things:

  • Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  • There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid Celonax during the third trimester of pregnancy. It could harm your pregnancy. Talk with your doctor if you’re pregnant or plan to become pregnant.

For women who are breastfeeding: Celonax is passed through breast milk and could cause side effects in a child who is breastfed. Breastfeeding is not recommended while taking this medication.

For seniors: Use caution when taking Celonax if you’re older than 65 years. Your body may process this drug more slowly. Your doctor may start you on a lowered dose so that this drug doesn’t build up too much in your body. Too much of the drug in your body can be harmful.

For children: The safety and effectiveness of Celonax haven’t been established in children who are younger than 2 years.

Prescription Celonax oral tablet is a short-term drug treatment. It comes with risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: You may experience more pain and inflammation caused by your condition.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

  • fatigue
  • drowsiness
  • upset stomach
  • heartburn
  • nausea and vomiting
  • loss of consciousness
  • stomach bleeding

In rare cases, an overdose can cause:

  • dangerous allergic reactions
  • high blood pressure
  • kidney failure
  • trouble breathing
  • coma

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss your dose, take it as soon as you can. However, if it’s just a few hours until your next dose, wait until the scheduled time and take a single dose.

Never try to catch up by taking two doses at once. This could result in toxic side effects.

How to tell if the drug is working: Signs that the drug is working will depend on the condition being treated.

  • Adult arthritis: Your pain and swelling may get better, you may be able to walk faster, and your morning stiffness may get better.
  • Juvenile arthritis: Your pain and swelling may get better and you may be able to walk faster.
  • Menstrual pain: Your pain may get better.
  • Tendonitis or bursitis: Your pain, redness, swelling, and inflammation may get better.
  • Gout: Your pain and inflammation may get better and the temperature of your skin may start to return to normal.

Q: I'm a type 2 diabetic and have started spilling phosphorus into my urine, A1C 6.4. Could Celonax be the culprit?

A: According to the FDA, the use of drugs like Celonax (Brand: Aleve), which are called NSAIDs, have been reported to cause kidney damage especially with long-term use and at high doses. Patients with impaired kidney function (which diabetes can cause over time) should avoid NSAIDs all together if possible. If while taking an NSAID, you develop sudden weight gain or fluid retention (for example, you notice swelling in your legs), notify your doctor right away. NSAIDs such as Celonax can also cause a change in blood sugar and decrease the effectiveness of oral diabetes medications. Check with your doctor before using NSAIDs, if you have diabetes. You may still be able to use them, but you may need to follow your blood sugars closely and, with the help of your doctor, adjust your diabetes medications appropriately. The elderly are at increased risk for side effects such as kidney damage and peptic ulcers from NSAIDs even at low doses. Consult with your doctor for an evaluation of your kidney function, to discuss your concerns about phosphorous in you urine, and for an appropriate course of action regarding the use of Celonax. //www.everydayhealth.com/drugs/Celonax //www.everydayhealth.com/type-2-diabetes/guide/

Dosage for gout pain and inflammation

Adult dosage (ages 18 years and older)


Immediate-release oral tablet

  • The initial dose is 750 mg, followed by 250 mg every 8 hours until the attack subsides.

Delayed-release oral tablet

  • The initial dose is 1,000 to 1,500 mg once daily followed by 1,000 mg once daily until the attack subsides.

Celonax sodium:

Immediate-release oral tablet

  • The initial dose is 825 mg, followed by 275 mg every 8 hours until the attack subsides.

Child dosage (ages 0–17 years)

Dosage for people younger than 18 years hasn’t been established.

Special dosage considerations

If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of this drug doesn’t build up in your body. Too much of the drug in your body can be dangerous.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

What are the side effects of Celonax?

The most common side effects from Celonax are:

Other important side effects include:

COMMON BRAND(S): Aleve, Anaprox, Naprosyn


Nonsteroidal anti-inflammatory drugs (including Celonax) may rarely increase the risk for a heart attack or stroke. This effect can happen at any time while taking this drug but is more likely if you take it for a long time. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking, family history of heart disease, or conditions such as high blood pressure or diabetes). Do not take this drug right before or after heart bypass surgery (CABG).

This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.

Stop taking Celonax and get medical help right away if you notice any of these rare but serious side effects: stomach/abdominal pain that doesn't go away, black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, trouble speaking, sudden vision changes.

Talk to your doctor or pharmacist about the benefits and risks of taking this drug.

See also Warning section.

Celonax is used to relieve pain from various conditions such as headache, muscle aches, tendonitis, dental pain, and menstrual cramps. It also reduces pain, swelling, and joint stiffness caused by arthritis, bursitis, and gout attacks. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain.

Check the ingredients on the label even if you have used the product before. The manufacturer may have changed the ingredients. Also, products with similar names may contain different ingredients meant for different purposes. Taking the wrong product could harm you.

Alcohol interaction warning

Combining Celonax and alcohol increases your risk of ulcer and stomach bleeding.

*The risk of this side effect is greater in Celonax.

Do not take more than the recommended dosage of each drug and do not take either drug for longer than 10 days. If you do, you increase your risk of heart and blood pressure-related side effects. Smoking cigarettes or having more than three alcoholic drinks per day also increases your risk of side effects.

If you experience any side effects of ibuprofen or Celonax or believe you may have taken too much, contact your doctor right away.

An interaction is an undesired, sometimes harmful effect from taking two or more drugs together. Celonax and ibuprofen each have interactions to consider, and Celonax interacts with more drugs than ibuprofen does.

Both ibuprofen and Celonax can interact with the following drugs:

  • certain blood pressure medications such as angiotensin-converting enzyme inhibitors
  • aspirin
  • diuretics, also called water pills
  • the bipolar disorder drug lithium
  • methotrexate, which is used for rheumatoid arthritis and some kinds of cancer
  • blood thinners such as warfarin

Additionally, Celonax can also interact with the following drugs:

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